When planning a visit to Saint Louis the most important decision you'll make is the area in which you stay. Choose St. Charles and you'll spend half your trip in the car instead of enjoying the sites. Too close to downtown and you'll have trouble getting the basic goods that you need. Clayton is situated 15 minutes or less from everything Saint Louis has to offer and is a worthy destination in its own right.
There really is no place like it.
The location is also particularly well suited if Washington University or Barnes Hospital is your reason for visiting St. Louis. The Wash U campus is two stops away on the Metrolink Light Rail. The dorms are a 4 minute drive (per Google Maps) straight down Forest Park Parkway ("South 40") or a very pleasant 20 minute walk down beautiful Wydown Blvd. Get to know your son or daughter's new friends over a home cooked meal, stay focused and flexible during a campus visit, or ensure yourself a quiet, private, space to work, think, and entertain while attending a conference or symposium.
Estate 77 is a gorgeous three bedroom house at the geographic center of Clayton. The house is in immaculate condition and decorated to create a sense of home and understated elegance.