Discover a selection of 132 holiday rentals in Panacea that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo holiday homes have the best amenities for hanging out with the people that matter most, including pool and air conditioning. Prices start at £ 113 per night, and houses and flats & apartments are popular options for a stay in Panacea. Either way, you'll find a rental for everyone's needs.
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Top rated rentals — Panacea
Destination guide

Head to the relaxing city of Panacea

The beaches and wildlife provide a pleasant backdrop to your holiday home in Panacea. Travellers to this relaxing city praise the dolphin watching, seafood restaurants and fishing. With a holiday rental, you get a home away from home – many rentals offer full kitchens and outdoor grills for some home cooking.


Seasonal weather averages in Panacea

If you're planning a holiday around the weather, July, June, August and September are the hottest months to visit, when temperatures average 33°F.

Natural features

Exploring the natural landscape of Panacea

Whether you're an active traveller or just want to appreciate the scenery, Panacea is a great place to spend some time outside. These are a few of the area's noteworthy sights, all within 30 miles (48.2 km) of the city centre:

  • San Marcos de Apalache Historic State Park (17 mi / 27.3 km)
  • Dog Island (18.8 mi / 30.3 km)
  • St. Marks National Wildlife Refuge (19.5 mi / 31.4 km)
  • Wakulla Springs State Park (19.6 mi / 31.6 km)
How to get there

How to get to and around Panacea

The nearest airport is in Tallahassee, FL (TLH-Tallahassee Regional), located 30.2 mi (48.6 km) from the city centre.

Can I find a vacation rental around Panacea?

Yes, our 2021 property listings offer a large selection of 132 vacation rentals near Panacea. From 105 houses to 18 flats & apartments, find a unique house rental for you to enjoy a memorable stay with your family and friends. The best places to stay near Panacea for a holiday or a weekend are on Vrbo.