The best vacay spots in SC – Debordieu rentals and more

Crossing dune landscapes and sea oat groves, ancient oak forests and rural swathes of farms in the Upcountry, South Carolina packs in laid-back beach towns, happening university cities, and immersive colonial-era centers alike. This destination guide hops from coveted Debordieu rentals right by the frothing whitecaps of the ocean to vacation rentals Greenville, SC, where family fun and theaters abound.

Debordieu rentals for an escape to the Atlantic

Azure seas and clean surf, white-tinted sands and undulating dunes – this is the backdrop to Debordieu rentals, which sit in a quiet and quaint colony of houses in Georgetown County. The surrounding region is covered by swathes of nature reserves – 800 acres worth, in fact – which means these are the pads to look to if you're pining after untouched, pristine coastline.

Murrells Inlet, NC rentals – the charms of the ocean

Capping off the famous Grand Strand on its southern end is Murrells Inlet. The smell of salty ships and the sound of flapping sails are the backing track as you stroll its Marsh Walk boardwalk area, while sculpture gardens and botanical parks add an air of refinement to the place. Murrells Inlet rentals help with that. They are largely stunning beachfront condos or luxurious lodges with porches overlooking the waves.

Dewees Island rentals to leave behind civilization

You're almost as likely to meet a slow-coach turtle or spot a bottlenose dolphin in the waves as you are to meet another human over on Dewees Island. That's just how remote and away-from-it-all this one is. You'll need to hop a ferry to get there, and be sure to ditch the auto – it's only navigable with an electric golf cart. Then, seek out a beautiful Dewees Island rental just meters from the empty beach, or a place backing onto wooded wetland parks, to crank up your R&R for a week or two.

See Charleston with Mt Pleasant, SC, vacation rentals

Extending like a long arm out of the north-east side of historic Charleston is Mt Pleasant. It's a region filled with bayous and old plantations, topped by gnarled oaks and Spanish moss. What's more, the vacation rentals in Mt Pleasant, SC, tend to be cheaper than their compadres in the heart of the cobblestone center of the French Quarter and old Charleston. That means they're a great family base for hitting the Civil War forts and colonial sights, promising all the fun without the budget-breaking rates.

The joy of Grand Strand vacations and rentals

Anchored by pulsing Myrtle Beach – the original boardwalk and good-time coastal escape in SC – the 60 miles of sparkling beaches that stretch around this part of the East Coast are nothing short of legendary. Grand Strand vacation rentals come in all shapes and sizes. Close to the Ferris wheel and the sports bars of the pier, it's all spring breaker condos. Further north, in Cherry Grove, elegant homes sit close to golf courses. Down south, Surfside has salty shacks next to board rentals.

Get a fix of culture in Greenville

Greenville could just be the Palmetto State's most attractive town. And the secret's well and truly out, with boom times rolling and vacation rentals in Greenville, SC, always in high demand. You'll see why as recline on your balcony overlooking the reflective Reedy River. You'll understand what all the fuss is about as you snuggle up in cozy cottages that hide in the woodlands on the cusp of Appalachia. And when it rains? Delve into the Bob Jones University Museum and Gallery for amazing works by Old Masters and European greats.