Discover a selection of 1,000 vacation rentals in Panama that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and WiFi. Prices start at $79 per night, and houses and villas are popular options for a stay in Panama. Either way, you'll find a rental for everyone's needs.
Top rated rentals — Panama
Destination guide

Outdoor adventures in picturesque Panama

Occupying the isthmus between Central and South America, Panama is in a world of its own. A tropical land of haunting cloud forests, towering mountains and flawless blonde beaches, it's spliced through by the Panama Canal, an incredible feat of engineering. Ideal for adventures, you can speed through rainforest canopies on a zip line, trek to breathtaking vantage points, raft along rivers or just relax on a sun-kissed beach. Paying a visit? Be sure to check out Panama City. A Miami-like sprawl of skyscrapers, it's home to some of the very best Panama vacation rentals, with casinos, historic monuments and energetic nightlife to explore.

Things to do

Picturesque plazas in Panama City

Choosing a Panama vacation rental in the capital is the best bet if you want to tick the star attractions off your to-do list. Cutting through the country and linking the Atlantic and Pacific Oceans, the 77-kilometer Panama Canal is the most famous of them. A major shipping route first used in 1914, the waterway's rich history can be discovered at the Interoceanic Canal Museum. Small but perfectly formed, Casco Viejo is Panama City's coolest, smallest and oldest neighborhood. Rebuilt in the late-1600s after being destroyed by pirates, the UNESCO World Heritage Site is home to crumbling churches, beautifully-restored colonial facades and picturesque plazas.


Waterfront living in fun-packed Panama

With its beach-laced Caribbean and Pacific coastlines, it's no surprise that watersports dominate the agenda. Snorkel among enchanting reefs in Bocas del Toro, dive with whale sharks in the Pacific, raft the racing waters of the Chiriqui Province or catch the surf in Santa Catalina, the choice is yours. If you prefer to stay on dry land, rock climbing and guided treks through the rainforest can fill your itinerary instead. When you want to unwind, you can soak in a hot spring, enjoy a fresh local coffee or let off steam in a fiesta-fuelled nightclub.


Feel the heat in sun-soaked Panama

Wherever you choose your Panama vacation rental, the climate doesn't vary too much, unless you're up in the mountain ranges, where it's much cooler. Boasting a tropical climate, Panama maintains a high and humid temperature all-year round, with an average high of around 86 degrees, good news if you enjoy hot weather. While visitors come here throughout the year, the dry season is the most-desirable time. It runs from mid-December through mid-April, with sporadic rain falling outside the season.

Natural features

Rivers, mountains and more in spectacular Panama

Hemmed between Colombia, Costa Rica and the Caribbean and Pacific Oceans, it's no surprise that Panama has such a diverse and spectacular landscape. Geographic features range from mysterious mangroves and rippling rivers that meander through valleys, to beautiful beaches and wild, impenetrable jungle. The dominant natural landmark is the verdant Cordillera de Talamanca mountain range, which sits beside the Costa Rica border. For wildlife lovers, Panama is a paradise. Visit the jungle to see creatures such as sloths, marmosets and capuchin monkeys, to name but a few.

How many vacation rentals are available around Panama?

Our 2020 property listings offer a large selection of 815 vacation rentals around Panama. From 387 house rentals to 71 villa rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

What are the most popular destinations to visit in Panama?

There are many lovely places to stay for a holiday trip or just for a weekend in Panama. From Vrbo travelers, the top most popular destinations to visit are:

  • Panama City: 190 vacation rentals
  • Bocas del Toro (province): 121 vacation rentals
  • Boquete: 67 vacation rentals
  • San Francisco: 178 vacation rentals
  • Playa Coronado: 126 vacation rentals

And Vrbo offers you the chance to discover many other popular destinations in Panama! Please use our search bar to access the selection of vacation rentals available in other popular destinations.

What are the main cities to discover in Panama?

Whether you're traveling with family or friends, here are the cities with the largest selection of vacation rentals for a holiday trip or just for a weekend in Panama:

  • Panama City: 190 rentals
  • Boquete: 67 rentals
  • Isla Bastimentos: 113 rentals
  • Nueva Gorgona: 132 rentals
  • Rio Hato: 127 rentals

For other cities, please use our search bar to access the selection of vacation rentals available.

Can I find easy-access vacation rentals when traveling by plane to Panama?

Yes of course. Our owners offer a large selection of vacation rentals near airports. The airports with a large selection of vacation rentals in Panama are:

  • Panama City (PTY-Tocumen Intl.): 178 vacation rentals
  • Rio Hato (RIH-Scarlett Martinez Intl.): 141 vacation rentals
  • Bocas del Toro (BOC-Bocas del Toro Intl.): 120 vacation rentals

For other airports, please use our search bar to access the selection of vacation rentals available.

Near which points of interest can I spend my holidays in Panama?

Vrbo offers a large selection of rentals near lovely places in Panama. From Vrbo travelers, the top most popular points of interest to stay for a holiday trip or just for a weekend are:

  • Playa Blanca: 81 rentals
  • El Cangrejo: 194 rentals
  • Panama Viejo: 193 rentals
  • Farallon Island: 147 rentals
  • Volcan Baru National Park: 68 rentals

But there are many other points of interest around Panama listed on Vrbo where you can find your place to stay. Just write your wanted destination in our search bar and have a look at our selection.

Explore destinations around Panama

Panama City
190 vacation rentals
67 vacation rentals
Isla Bastimentos
113 vacation rentals
Nueva Gorgona
132 vacation rentals
Rio Hato
127 vacation rentals
San Carlos
221 vacation rentals
41 vacation rentals
Boca Chica
28 vacation rentals
Tierra Oscura
120 vacation rentals
El Chiru
77 vacation rentals
El Valle de Anton
26 vacation rentals
17 vacation rentals
Bocas del Toro
84 vacation rentals
60 vacation rentals
Alto Boquete
60 vacation rentals
70 vacation rentals
148 vacation rentals
San Miguelito
149 vacation rentals
Punta Chame
113 vacation rentals
Paso Ancho
58 vacation rentals