James Island house rentals

Choose from 4,068 vacation home rentals around James Island and then start planning your next memorable adventure. Wherever you’re headed and whoever’s going with you, your ideal home away from home is on Vrbo.

Your perfect vacation home rental in James Island is waiting for you on Vrbo, with a range of prices from budget-friendly accommodations to more exclusive properties. Enter your trip details to compare, ensuring you find the right place for you and your crew.

That depends on what you plan to see and if you want to visit in high or low season. February is the busiest month for booking a vacation home rental in James Island. Average temperatures during this time range between 48ºF (9ºC) and 60ºF (16ºC).

Vrbo makes it easy to find the stunning views you’re looking for in your vacation house. Just use our “Location” filter to narrow down the type of area you’d prefer to stay in, and the views you like to immerse yourself in, while searching vacation home rentals in James Island.

You’ll discover some quality houses that are available for weekend rental. Simply key in your travel dates and prepare for a spontaneous few days of fun. If you don’t find the ideal vacation home rental in James Island right away, just play around with your dates and search again.

If you’d like to enjoy James Island with your loyal companion at your side, use our handy filter tool to search for pet-friendly houses. Check the “Pets allowed” box to find a vacation home rental with welcome touches like dog toys and complimentary treats. Because when the family takes a trip, the pets should come along too!

Venture out and experience everything James Island has to offer from the comfort of your vacation home rental. It pays to do a bit of research on the things you’d like to see and do, so you can plan the perfect getaway.

When you select a Vrbo vacation home rental, the only people you’ll share your space with are those you take with you. It’ll only be you, family or friends and the entire property to yourselves. Plus, when you become a member of One Key™ rewards program, you can earn and spend OneKeyCash™* on all eligible bookings on Vrbo, Expedia and Hotels.com. Additionally, our flexible cancellation policies also mean you can book your rental house with peace of mind if you need to change your plans. *OneKeyCash disclaimer - OneKeyCash is not redeemable for cash and can only be used on Hotels.com, Expedia and Vrbo.