Discover a selection of more than 10,000 vacation rentals in South America that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and private pools. Prices start at $27 per night, and condos and houses are popular options for a stay in South America. Either way, you'll find a rental for everyone's needs.
Top rated rentals — South America
Destination guide

Heading south—a land where mountains and metropolises meld

No matter when or where you book a South America vacation rental, you'll find yourself on a remarkable continent with a vast and varied landscape. For those who love big city living, South America has plenty of thriving metropolises with world-renowned museums by day and bustling bars by night. Sandy ocean beaches, magnificent mountains, sprawling lakes, lush rainforests, and 1 of the most famous rivers in the world all beckon outdoor adventurers. Along the southern tip of the continent you'll find a drastically different landscape, complete with with towering glaciers and icebergs.

Things to do

A broad canvas—from thriving art scenes to national parks

Major South American cities offer big adventures, such as Rio de Janeiro, where a railway car travels to the top of Mount Corcovado for views of the iconic, 98-foot-tall Christ the Redeemer statue. For a culture fix, Buenos Aires in Argentina is home to the renowned Latin American Art Museum and the Teatro Colon, a grand 1908 opera house. For a more peaceful experience, book a South America vacation rental near Torres del Paine National Park in Chile's Patagonia region, featuring glaciers, icebergs, and expansive grasslands, or visit Lake Titicaca, a deep lake in the Andes surrounded by ancient Incan ruins.


Don't forget to pack your hiking boots… and dancing shoes!

Peru's Inca Trail lets hikers take a walk in the clouds across the Andes mountain range, before ending at the abandoned Incan city of Machu Picchu. For thrilling water-based activities, take a jetboat ride near the mammoth Iguazu Falls, set along the border of Argentina and Brazil, or cool off with a swim in the Atlantic and Pacific Ocean. The Brazilian beaches of Rio de Janeiro are famous for sunbathing, soccer, and beach volleyball. If you're booking a South America vacation rental around the start of Lent, Carnaval celebrations across the continent provide all-night parties with parades, dancing, and music.


Sunscreen, scarves, snow pants, and everything in between

If you're visiting South America's tropical climates, such as the Amazon rainforest, dress for warm, humid weather as the daily temperature averages around 86 degrees and about 100 inches of rain falls each year. Some regions, like northwestern Argentina and the Atacama Desert, feature more varied climates, including warm summers, cold winters, and little rainfall. Make sure you pack a parka if you're visiting areas like Patagonia and the high Andes, where cold year-round climates include plenty of snow and temperatures well below freezing. Violent and biting winds whip through the barren landscape as well.

Natural features

Wild at heart—wandering rivers and towering waterfalls

Some of the world's most majestic waterfalls are in South America, including Venezuela's Angel Falls, 1 of the world's highest waterfalls at over 3,200 feet. The watery landscape continues as the longest river in the world, the Amazon, snakes down the continent for 4,300-plus miles. Astoundingly, more than one-third of all known species in the world live in the Amazon and its surrounding forest, including howler monkeys, sloths, dart frogs, and jaguars. The majestic peaks of the Andes mountains, which run along the western edge of South America for about 4,300 miles, play host to roaming llamas and alpacas.

How many vacation rentals are available around South America?

Our 2021 property listings offer a large selection of 46,283 vacation rentals around South America. From 22,729 condo and apartment rentals to 19,568 house rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

What are the most popular destinations to visit in South America?

There are many lovely places to stay for a holiday trip or just for a weekend in South America. From Vrbo travelers, the top most popular destinations to visit are:

  • Cartagena: 989 vacation rentals
  • Copacabana: 1,383 vacation rentals
  • Miraflores: 454 vacation rentals
  • El Poblado: 609 vacation rentals
  • Buenos Aires Central Business District: 418 vacation rentals

And Vrbo offers you the chance to discover many other popular destinations in South America! Please use our search bar to access the selection of vacation rentals available in other popular destinations.

What are the main cities to discover in South America?

Whether you're traveling with family or friends, here are the cities with the largest selection of vacation rentals for a holiday trip or just for a weekend in South America:

  • Cartagena: 989 rentals
  • Santiago: 426 rentals
  • Quito: 255 rentals
  • Bogotá: 785 rentals
  • Cali: 326 rentals

For other cities, please use our search bar to access the selection of vacation rentals available.

Can I find easy-access vacation rentals when traveling by plane to South America?

Yes of course. Our owners offer a large selection of vacation rentals near airports. The airports with a large selection of vacation rentals in South America are:

  • Cartagena (CTG-Rafael Nunez Intl.): 1,018 vacation rentals
  • Portoviejo (PVO-Reales Tamarindos): 29 vacation rentals
  • Sao Paulo (GRU-Guarulhos - Governor Andre Franco Montoro Intl.): 958 vacation rentals

For other airports, please use our search bar to access the selection of vacation rentals available.

Near which points of interest can I spend my holidays in South America?

Vrbo offers a large selection of rentals near lovely places in South America. From Vrbo travelers, the top most popular points of interest to stay for a holiday trip or just for a weekend are:

  • The Tree House: 20 rentals
  • Tayrona National Natural Park: 327 rentals
  • Departamento Iguazú: 25 rentals
  • Salta: 43 rentals
  • Rosario Centro: 25 rentals

But there are many other points of interest around South America listed on Vrbo where you can find your place to stay. Just write your wanted destination in our search bar and have a look at our selection.

Explore destinations around South America

Buenos Aires
1,158 vacation rentals
67 vacation rentals
54 vacation rentals
Lima Region
729 vacation rentals
Salta Province
61 vacation rentals
Rio de Janeiro State
6,899 vacation rentals
Cusco Region
414 vacation rentals
1,032 vacation rentals
Federal District State
153 vacation rentals
26 vacation rentals
1,194 vacation rentals
San Luis Province
20 vacation rentals
Santa Cruz
41 vacation rentals
Ica Region
19 vacation rentals
85 vacation rentals
Santiago Metropolitan Region
433 vacation rentals
106 vacation rentals
Arequipa Region
42 vacation rentals
18 vacation rentals
Santa Fe Province
31 vacation rentals