Discover a selection of 494 vacation rentals in Mission District, San Francisco that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including parking and WiFi. Prices start at $45 per night, and houses and condos are popular options for a stay in Mission District. Either way, you'll find a rental for everyone's needs.
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Destination guide

Multiculturalism in the Mission District

Famously multicultural, the Mission District is one of San Francisco's most eclectic neighborhoods. It's an enclave for Latin American immigrants, which means you'll find traditional taquerias, colorful produce stalls and local bodegas on every corner. Thanks to its free-spirited attitude, the Mission District has become a popular hangout for hipsters. As a result, the neighborhood has also seen an explosion of live-music clubs, trendy third wave coffee shops, tattoo parlors and craft cocktail bars. If you want to experience the city through a local lens, Mission District vacation rentals unlock access to this captivating slice of San Francisco.

Things to do

Gallery hopping in the Mission District

While the Mission District is best known for its street art, galleries like Southern Exposure champion a curated approach. Also known as SoEx, this contemporary non-profit gallery showcases San Francisco's up-and-coming visual artists. For a unique night out, score tickets to a show at the Roxie Theater, San Francisco's original playhouse. More than 100 years old, it screens cult classics, film noirs, vintage horrors, edgy documentaries and more. For a glimpse of the neighborhood's namesake, head to Mission Dolores. Founded in 1776, the enclave is one of San Francisco's oldest buildings.

Activities

Street art and murals in the Mission District

Thanks to its vibrant Latino roots, the Mission District is a hub for arts and culture. Clad in colorful murals, Clarion Alley is one of San Francisco's most-photographed streets. Upmarket Valencia Street boasts some of San Francisco's best shopping, with a myriad of trendy boutiques and independent designers to discover. You'll also find a glut of artisan coffee shops, Mexican eateries and vegan cafes. Want to stay local? Mission District vacation rentals put you just steps from Valencia Street. Head down Mission Street and you'll find a treasure trove of sidewalk stalls selling second-hand clothes, handcrafted wares and everything in-between.

Weather

Soak up the sunshine in the Mission District

Thanks to its sheltered position behind Twin Peaks, the Mission District enjoys some of San Francisco's best weather. The hills block fog from the Pacific Ocean and create a sunny microclimate. This means that when the Golden Gate Bridge is enveloped in fog, Mission District vacation rentals will often bask in idyllic weather. Summer is high season in the Bay Area, with clear skies and warm temperatures. The Mission District throws some of San Francisco's biggest events, including the Fat Tuesday Mardi Gras, Dia de los Muertos and Memorial Day "Carnaval" festival.

Natural features

The Mission District is perfect for picnics

The Mission District is anchored by Dolores Park, the neighborhood's signature green space. It lures locals with grassy lawns, lush palms and sweeping views of the San Francisco skyline. On a sunny day, there's no better place to enjoy a picnic and a bottle of wine. Located in the grounds of Mission Dolores, the Golden Gate Rose Society Garden is one of the city's best-kept secrets. Inside you'll find a wonderland of sumptuous rose gardens. The Native American-themed botanic garden, filled with indigenous plants, is also worth a visit.

How to get there

How to get to and around Mission District

Fly into San Francisco, CA (SFO-San Francisco Intl.), the closest airport, located 10 mi (16.1 km) from the city center. If you can't find a flight that's convenient for your trip, you could also fly into Oakland, CA (OAK-Oakland Intl.), which is 11.6 mi (18.6 km) away.

Consider catching a ride on the metro at 16th Street Mission Station or 24th Street Mission Station and easily see more of the city.

How many vacation rentals are available around Mission District, San Francisco?

Our 2020 property listings offer a large selection of 494 vacation rentals around Mission District. From 156 house rentals to 242 condo and apartment rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

What is the best area to stay when traveling to Mission District?

Whether you're traveling with family or friends, here are the areas with the largest selection of vacation rentals for a holiday trip or just for a weekend in Mission District:

  • Tenderloin: 192 vacation rentals
  • Financial District: 386 vacation rentals
  • Marina District: 318 vacation rentals
  • Nob Hill: 350 vacation rentals
  • Hayes Valley: 581 vacation rentals

For other neighborhoods, please use our search bar to access the selection of vacation rentals available.

What are the popular point of interests near where I can stay when traveling to Mission District?

Vrbo offers a large selection of vacation rentals near lovely places in Mission District. From Vrbo travelers, the top most popular points of interest to stay for a holiday trip or just for a weekend are:

  • Southern Exposure: 1,950 vacation rentals
  • Eleanor Harwood Gallery: 1,943 vacation rentals
  • Balmy Alley: 1,948 vacation rentals
  • Marsh Theater: 1,943 vacation rentals
  • Hosfelt Gallery: 1,940 vacation rentals

But there are many other points of interest around Mission District listed on Vrbo where you can find your place to stay. Please use our search bar to access the selection of vacation rentals available near the point of interest of your choice.

Can I rent Houses in Mission District?

Yes, of course. Vrbo has 156 Houses in Mission District. Our other popular types of vacation rentals in Mission District include:

  • Condos/Apartments: 242 rentals available
  • Studios: 212 rentals available
  • Hotels: 49 rentals available

But you can also enjoy a great stay in one of our other vacation rentals including Cottages and more.

Can I find a vacation rental with pool in Mission District?

Yes, you can select your preferred vacation rental with pool among our 24 vacation rentals with pool available in Mission District. Please use our search bar to access the selection of vacation rentals available.

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