Discover a selection of 500 vacation rentals in Mission District, San Francisco that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and private pools. Prices start at $84 per night, and houses and condos are popular options for a stay in Mission District. Either way, you'll find a rental for everyone's needs.
Top rated rentals — Mission District
Destination guide

Discover Mission District apartments

Renowned for its hipster appeal and vibrant Latino culture, the Mission District is the perfect place for San Francisco apartments. It's filled with unique experiences and places, including traditional taquerias, gourmet eateries, thrilling live-music venues, and innovative restaurants. The street art is some of the best in the whole city, with many streets lined with spectacular murals from local artists. Along with the modern experiences, the Mission District is also home to the Mission Dolores Basilica, which is the oldest intact building in the city. The chapel often hosts events, such as live music concerts and performances.

Things to do

Gallery hopping in the Mission District

While the Mission District is best known for its street art, galleries like Southern Exposure champion a curated approach. Also known as SoEx, this contemporary non-profit gallery showcases San Francisco's up-and-coming visual artists. For a unique night out, score tickets to a show at the Roxie Theater, San Francisco's original playhouse. More than 100 years old, it screens cult classics, film noirs, vintage horrors, edgy documentaries and more. For a glimpse of the neighborhood's namesake, head to Mission Dolores. Founded in 1776, the enclave is one of San Francisco's oldest buildings.


Street art and murals in the Mission District

Thanks to its vibrant Latino roots, the Mission District is a hub for arts and culture. Clad in colorful murals, Clarion Alley is one of San Francisco's most-photographed streets. Upmarket Valencia Street boasts some of San Francisco's best shopping, with a myriad of trendy boutiques and independent designers to discover. You'll also find a glut of artisan coffee shops, Mexican eateries and vegan cafes. Want to stay local? Mission District vacation rentals put you just steps from Valencia Street. Head down Mission Street and you'll find a treasure trove of sidewalk stalls selling second-hand clothes, handcrafted wares and everything in-between.


Soak up the sunshine in the Mission District

Thanks to its sheltered position behind Twin Peaks, the Mission District enjoys some of San Francisco's best weather. The hills block fog from the Pacific Ocean and create a sunny microclimate. This means that when the Golden Gate Bridge is enveloped in fog, Mission District vacation rentals will often bask in idyllic weather. Summer is high season in the Bay Area, with clear skies and warm temperatures. The Mission District throws some of San Francisco's biggest events, including the Fat Tuesday Mardi Gras, Dia de los Muertos and Memorial Day "Carnaval" festival.

Natural features

The Mission District is perfect for picnics

The Mission District is anchored by Dolores Park, the neighborhood's signature green space. It lures locals with grassy lawns, lush palms and sweeping views of the San Francisco skyline. On a sunny day, there's no better place to enjoy a picnic and a bottle of wine. Located in the grounds of Mission Dolores, the Golden Gate Rose Society Garden is one of the city's best-kept secrets. Inside you'll find a wonderland of sumptuous rose gardens. The Native American-themed botanic garden, filled with indigenous plants, is also worth a visit.

How to get there

How to get to and around Mission District

Fly into San Francisco, CA (SFO-San Francisco Intl.), the closest airport, located 10 mi (16.1 km) from the city center. If you can't find a flight that's convenient for your trip, you could also fly into Oakland, CA (OAK-Oakland Intl.), which is 11.6 mi (18.6 km) away.

Consider catching a ride on the metro at 16th Street Mission Station or 24th Street Mission Station and easily see more of the city.

How many vacation rentals are available around Mission District, San Francisco?

Our 2021 property listings offer a large selection of 637 vacation rentals around Mission District. From 129 house rentals to 387 condo and apartment rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

What are the popular point of interests near where I can stay when traveling to Mission District?

Vrbo offers a large selection of vacation rentals near lovely places in Mission District. From Vrbo travelers, the top most popular points of interest to stay for a holiday trip or just for a weekend are:

  • 24th Street Mission Station: 2,391 vacation rentals
  • Southern Exposure: 2,425 vacation rentals
  • Balmy Alley: 2,393 vacation rentals
  • Marsh Theater: 2,416 vacation rentals
  • Eleanor Harwood Gallery: 2,379 vacation rentals

But there are many other points of interest around Mission District listed on Vrbo where you can find your place to stay. Please use our search bar to access the selection of vacation rentals available near the point of interest of your choice.

Can I rent Houses in Mission District?

Yes, of course. Vrbo has 129 Houses in Mission District. Our other popular types of vacation rentals in Mission District include:

  • Condos/Apartments: 387 rentals available
  • Studios: 289 rentals available
  • Hotels: 108 rentals available

But you can also enjoy a great stay in one of our other vacation rentals including Cottages and more.

Can I find a vacation rental with pool in Mission District?

Yes, you can select your preferred vacation rental with pool among our 41 vacation rentals with pool available in Mission District. Please use our search bar to access the selection of vacation rentals available.