Discover a selection of 120 vacation rentals in Southern Precinct that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and WiFi. Prices start at $182 per night, and cabins and houses are popular options for a stay in Southern Precinct. Either way, you'll find a rental for everyone's needs.
Top rated rentals — Southern Precinct
Destination guide

An oasis of calm in Southern, Illinois

Covering a third of the state, Southern is a wonderland of shimmering lakes, national forests, and sprawling fruit orchards. From cozy log cabins to luxurious lakefront properties, Southern vacation rentals put you in the heart of rural Illinois. The'mighty Mississippi River'forms the western boundary, with the forested Shawnee Hills rising to the east. Whether you're embarking on a romantic weekend away, a fishing trip or a fun-filled family vacation, you're bound to fall under Southern's spell.

Things to do

Sip your way through the southern Illinois wine trail

Jackson County is a hotspot for heritage tourism, with most of the highlights found in Murphysboro. Don't miss the General John A. Logan Museum, Robert W. Hamilton House, and Tower Grove Cemetery. You can also head south to the Lewis & Clark Expedition's starting point, wander around the ruins of Fort Kaskaskia, and discover prehistoric America at the Cahokia Mounds State Historic Site. Love vino? Renting a car gives you the freedom to sip your way through the Southern Illinois Wine Trail. More than 50 boutique wineries dot the region, including the awardwinning Blue Sky Vineyard.


Discover Southern's treasure trove of towns

From Murphysboro to Makanda, southern Illinois is dotted with pint-sized towns and cities, each with its own unique personality. From your Southern vacation rental, you can work your way through a treasure trove of characterful caf_s, art galleries, antiques stores, and more. Hugging the banks of the Mississippi, the Great River Road byway showcases some of the state's best scenery. Don't miss Highway 100 between Grafton and Alton, a knockout stretch of road that will take you right past the hidden hamlet of Elsah. With its 19th-century stone cottages and traditional farmhouses, it's like going back in time.


Peachy summers in Southern Illinois

Verging on subtropical, Southern Illinois enjoys sultry summers and mild winters, lending itself to vacations throughout the year. Both spring and fall are fantastic times to hop your way through the state's charming towns, heritage sites, and natural attractions. Jackson County is famous for its orchards, which makes summer one of the best times to devour fresh peaches and nectarines. With outdoor decks, private docks, and BBQs that are ready to be fired up, Southern vacation rentals offer the perfect way to relax after a long day of sightseeing.

Natural features

A breath of fresh air in Shawnee National Forest

While flat farmlands dominate the upper portion of the state, southern Illinois is known for its rolling landscapes, wildflower-strewn state parks, and myriad of lakes. Shawnee National Forest harbors most of the attention, with plenty of recreation areas like Little Grassy Lake where you can swim, kayak, and fish. Nearby Cypress Creek National Wildlife Refuge is a sanctuary for birds, with wooden boardwalks winding their way through the swamp. If you want to hike or canoe, the friendly rangers at the Henry N. Barkhausen Cache River Wetlands Center are happy to give you the scoop on local trails.

How many vacation rentals are available around Southern Precinct?

Our 2021 property listings offer a large selection of 120 vacation rentals around Southern Precinct. From 48 cabin rentals to 95 house rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.