Discover a selection of 206 vacation rentals in Rochester, MN that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including WiFi and swimming pools. Prices start at $45 per night, and houses and condos are popular options for a stay in Rochester. Either way, you'll find a rental for everyone's needs.
Top rated rentals — Rochester
Destination guide

Rochester: Home of the Mayo Clinic

It was way back in the late 1800s that the Mayo clan decided to establish their world-famous clinic in the small Minnesotan town of Rochester. In the decades since, that institution has grown to become one of the largest not-for-profit medical ventures on the planet, now drawing millions of visitors to this otherwise sleepy corner of the Midwest for treatment, medical research trials, and high-skilled jobs. Throw in a couple of top-notch craft breweries, and the wonderful rolling forests, lakes, and plains that spread away south out of Minneapolis, and it's easy to see why charming Rochester vacation rentals would be in high demand.

Things to do

Hospitals and heritage homes in Rochester

Of course, a glimpse at the groundbreaking Plummer Building and the other complexes of the original Mayo Clinic is a must for visitors to Rochester. This is the most defining landmark in the city, and tells the tale of the foundation's growth into a global not-for-profit. Also in the downtown district is the acclaimed Heritage House Victorian Museum, which chronicles the life and times of 18th-century Midwesterners with its antique-heavy rooms and distinct period furnishings. Mayowood Mansion is worth a stopover too, as the former home of Charles Mayo and for its spot on the National Register of Historic Places.


Parks and Minnesotan history in Rochester

There's no question that the home of the famous Mayo Clinic has plenty more up its sleeve than just hospital rooms and research laboratories. Visitors here can also spend time wandering charming nature preserves or unraveling fascinating tales of gold rush history from the 19th century. Others will look for Rochester vacation rentals close to Silver Lake, where golf courses, picnic spots, and quaint wedding venues all dot the green lands.


Choose summer over snow in Rochester

Rochester draws visitors all year round with its famous Mayo Clinic, but there's never a better time to drop into the town's sleepy streets than midsummer, sometime between late June and August. That's when the parks, creeks, golf courses, and meadows are all at their most beautiful, and when you'll be best set for seeking out the wildlife of Cascade Creek and the Carley State Park. It's all the top time for paying your respects at the Wall of Remembrance in the local Veteran's Memorial.

Natural features

Rochester is a city of parks and creeks

The Rochester metro area contains a total of 100 designated recreational spots, each with its own creeks, picnic spots, playgrounds, and jogging tracks. However, for a taste of the real Minnesotan wilds, you'll need to go further afield. You could pack up the camping gear and break away to the Oxbow Park in the west, or head east to the wilder Carley State Park, where white pines and orange-breasted orioles lurk over the hiking paths.

How to get there

How to get to and around Rochester

Fly into Rochester, MN (RST-Rochester Intl.), the closest airport, located 7.8 mi (12.5 km) from the city center.

How many vacation rentals are available around Rochester, MN?

Our 2021 property listings offer a large selection of 206 vacation rentals around Rochester. From 148 house rentals to 55 condo and apartment rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

What is the best area to stay when traveling to Rochester?

Whether you're traveling with family or friends, here are the areas with the largest selection of vacation rentals for a holiday trip or just for a weekend in Rochester:

  • Kutzky Park: 87 vacation rentals
  • Northrup: 89 vacation rentals
  • Slatterly Park: 51 vacation rentals
  • East Side Pioneers: 74 vacation rentals
  • Downtown Rochester: 94 vacation rentals

For other neighborhoods, please use our search bar to access the selection of vacation rentals available.

What are the popular point of interests near where I can stay when traveling to Rochester?

Vrbo offers a large selection of vacation rentals near lovely places in Rochester. From Vrbo travelers, the top most popular points of interest to stay for a holiday trip or just for a weekend are:

  • Mayo Clinic: 191 vacation rentals
  • Mayo Clinic Hospital - Saint Marys Campus: 207 vacation rentals
  • Olmsted County Fairgrounds: 207 vacation rentals
  • Mayo Civic Center: 207 vacation rentals
  • Mayowood Mansion: 205 vacation rentals

But there are many other points of interest around Rochester listed on Vrbo where you can find your place to stay. Please use our search bar to access the selection of vacation rentals available near the point of interest of your choice.

Can I rent Houses in Rochester?

Yes, of course. Vrbo has 148 Houses in Rochester. Our other popular types of vacation rentals in Rochester include:

  • Condos/Apartments: 55 rentals available
  • Townhouses: 3 rentals available
  • Studios: 33 rentals available

But you can also enjoy a great stay in one of our other vacation rentals including Farmhouses and more.

Can I find a vacation rental with pool in Rochester?

Yes, you can select your preferred vacation rental with pool among our 14 vacation rentals with pool available in Rochester. Please use our search bar to access the selection of vacation rentals available.