Discover a selection of 1,000 vacation rentals in St. Charles, MO that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and WiFi. Prices start at $82 per night, and houses and condos are popular options for a stay in St. Charles. Either way, you'll find a rental for everyone's needs.
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Top rated rentals — St. Charles
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Destination guide

A charming place on the Missouri River

Situated on the Missouri River, on the outskirts of Saint Louis, the city of Saint Charles has oodles of character. Renowned as the starting point of Lewis and Clark's famous expedition across America, this charming city boasts a buzzing downtown, brimming with great local shops and restaurants, in addition to its famous history. Choose a Saint Charles vacation rental to explore the city's historic downtown, its riverside parks, many local festivals and events, and the sights and sounds of nearby Saint Louis.

Things to do

History made in Saint Charles

In 1804, at the behest of President Thomas Jefferson, Lewis and Clark left from Saint Charles to find a route to the Pacific coast. Their achievements are celebrated in the city's riverside Frontier Park, home to the Lewis and Clark Boathouse, Nature Center and Museum. As well as charting the explorers' incredible journey, this family-friendly attraction displays include full-size replicas of boats used by the expedition. Explore local history further at the First Missouri State Capitol State Historic Site, former home of the state legislature. Or, for something a little less cerebral, how about touring some of the local wineries of Historic Missouri Wine Country?

Activities

A buzzing festival calendar

Concerts and events at the St. Charles Convention Center and the city's Family Arena bring many visitors to town. There's also a busy program of annual festivals throughout the year, held in the city's historic downtown and riverside spaces. Many fetes celebrate the city's German, Irish and Scottish ancestry, as well as its connection with the famous explorers. The Festival of the Little Hills is an August Saint Charles tradition, and one of the most respected craft fairs in the country. If you're new to Saint Charles, one great way to explore the historic downtown districts is to follow the city's self-guided audio walking tour.

Weather

Saint Charles through the year

Winters in Saint Charles can be cold, but snow is rare. The conditions are ideal for the city's Fete de Glace ice sculpting festival, a January tradition. As spring warms up, the streets come alive to the sounds of pipes and drums in the annual Missouri Tartan Day, a celebration of the signing of the Declaration of Arbroath in 1320. Expect a lively parade of bagpipes, tartan and Highland games. By summer, it's not unusual for temperatures climb into the 80s. Kick back and enjoy a refreshing drink or al fresco meal at a downtown restaurant or a sunny picnic in a local park.

Natural features

Riverside trails in Saint Charles

Saint Charles offers many greenspaces and attractive riverside hiking and biking trails. The Katy Trail is part of the vast Lewis and Clark trail and a Missouri state park. This route follows the line of a former railroad from Saint Charles, near the confluence of the Mississippi and Missouri Rivers. Closer to your Saint Charles' vacation rental, miles of hiking, biking and equestrian trails can be enjoyed at Dr. Edmund A. Babler Memorial State Park – a favorite picnicking and birding spot. Discover more about the Ozark border forest landscape and its wildlife in the park's River Hills Visitor Center.

How to get there

Transportation to and around St. Charles

Fly into St. Louis, MO (STL-Lambert-St. Louis Intl.), the closest airport, located 6.8 mi (10.9 km) from the city center. If you can't find a flight that works for your travel itinerary, you could also fly into St. Louis, MO (SUS-Spirit of St. Louis), which is 11.9 mi (19.1 km) away.

How many vacation rentals are available around St. Charles, MO?

Our 2021 property listings offer a large selection of 899 vacation rentals around St. Charles. From 399 house rentals to 487 condo and apartment rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

What are the popular point of interests near where I can stay when traveling to St. Charles?

Vrbo offers a large selection of vacation rentals near lovely places in St. Charles. From Vrbo travelers, the top most popular points of interest to stay for a holiday trip or just for a weekend are:

  • Katy Trail: 657 vacation rentals
  • Fast Lane Classic Cars: 518 vacation rentals
  • Missouri Bluffs Golf Course: 174 vacation rentals
  • Ameristar Casino St. Charles: 706 vacation rentals
  • Lewis & Clark Boathouse and Nature Center: 699 vacation rentals

But there are many other points of interest around St. Charles listed on Vrbo where you can find your place to stay. Please use our search bar to access the selection of vacation rentals available near the point of interest of your choice.

Can I rent Houses in St. Charles?

Yes, of course. Vrbo has 399 Houses in St. Charles. Our other popular types of vacation rentals in St. Charles include:

  • Condos/Apartments: 487 rentals available
  • Cabins: 81 rentals available
  • Studios: 411 rentals available

But you can also enjoy a great stay in one of our other vacation rentals including Villas and more.

Can I find a vacation rental with pool in St. Charles?

Yes, you can select your preferred vacation rental with pool among our 201 vacation rentals with pool available in St. Charles. Please use our search bar to access the selection of vacation rentals available.