Discover a selection of 26 vacation rentals in St. Charles, MO that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and WiFi. Prices start at $80 per night, and houses and condos are popular options for a stay in St. Charles. Either way, you'll find a rental for everyone's needs.
Destination guide

A charming place on the Missouri River

Situated on the Missouri River, on the outskirts of Saint Louis, the city of Saint Charles has oodles of character. Renowned as the starting point of Lewis and Clark's famous expedition across America, this charming city boasts a buzzing downtown, brimming with great local shops and restaurants, in addition to its famous history. Choose a Saint Charles vacation rental to explore the city's historic downtown, its riverside parks, many local festivals and events, and the sights and sounds of nearby Saint Louis.

Things to do

History made in Saint Charles

In 1804, at the behest of President Thomas Jefferson, Lewis and Clark left from Saint Charles to find a route to the Pacific coast. Their achievements are celebrated in the city's riverside Frontier Park, home to the Lewis and Clark Boathouse, Nature Center and Museum. As well as charting the explorers' incredible journey, this family-friendly attraction displays include full-size replicas of boats used by the expedition. Explore local history further at the First Missouri State Capitol State Historic Site, former home of the state legislature. Or, for something a little less cerebral, how about touring some of the local wineries of Historic Missouri Wine Country?


A buzzing festival calendar

Concerts and events at the St. Charles Convention Center and the city's Family Arena bring many visitors to town. There's also a busy program of annual festivals throughout the year, held in the city's historic downtown and riverside spaces. Many fetes celebrate the city's German, Irish and Scottish ancestry, as well as its connection with the famous explorers. The Festival of the Little Hills is an August Saint Charles tradition, and one of the most respected craft fairs in the country. If you're new to Saint Charles, one great way to explore the historic downtown districts is to follow the city's self-guided audio walking tour.


Saint Charles through the year

Winters in Saint Charles can be cold, but snow is rare. The conditions are ideal for the city's Fete de Glace ice sculpting festival, a January tradition. As spring warms up, the streets come alive to the sounds of pipes and drums in the annual Missouri Tartan Day, a celebration of the signing of the Declaration of Arbroath in 1320. Expect a lively parade of bagpipes, tartan and Highland games. By summer, it's not unusual for temperatures climb into the 80s. Kick back and enjoy a refreshing drink or al fresco meal at a downtown restaurant or a sunny picnic in a local park.

Natural features

Riverside trails in Saint Charles

Saint Charles offers many greenspaces and attractive riverside hiking and biking trails. The Katy Trail is part of the vast Lewis and Clark trail and a Missouri state park. This route follows the line of a former railroad from Saint Charles, near the confluence of the Mississippi and Missouri Rivers. Closer to your Saint Charles' vacation rental, miles of hiking, biking and equestrian trails can be enjoyed at Dr. Edmund A. Babler Memorial State Park – a favorite picnicking and birding spot. Discover more about the Ozark border forest landscape and its wildlife in the park's River Hills Visitor Center.

How to get there

Traveling to and around St. Charles

The nearest airport is in St. Louis Lambert Intl. Airport (STL), located 7.7 mi (12.5 km) from the city center. If you can't find a flight that works for your travel itinerary, you could book a flight to St. Louis, MO (SUS-Spirit of St. Louis), which is 11.7 mi (18.9 km) away.

What are the top vacation rentals in or near St. Charles?

Whatever vacation experience you're seeking, you'll find a rental property in or around St. Charles that's a match made in heaven. Why not try these on for size?:

  • "Premier Location: Heart Of The Italian Nbrhd" is a favorite with guests. Around 16 miles from St. Charles, it has 1 bedroom and loads of handy amenities, including books and an oven.
  • Another great choice is "1790's Renovated Barn, Historic Main Street St. Charles", which is around 1 mile from St. Charles. Featuring 2 bedrooms, a restaurant dining guide and a living room, it has everything you need to make your stay comfortable.

For even more great options, use the search bar at the top of the page to find the perfect St. Charles vacation rental for you.

What are the top-rated vacation rentals for weekend getaways in or near St. Charles?

If you're ready to switch off and relax for a day or two, there's no shortage of wonderful weekend getaways in and around St. Charles. Take a well-deserved break at one of these top options:

  • If exploring the great outdoors is a high priority for you, book a day or two at "Urban Industrial Loft Overlooking Downtown". Around 19 miles southeast of St. Charles, it's near Hamburg Trail Trailhead and Lewis and Clark Trail Trailhead. Amenities at this retreat include air conditioning and a bicycle.
  • Another terrific option is "Entire Dogtown House Near Zoo, Forest Park And Wash U", which is around 15 miles southeast of St. Charles. When you're not hanging in your rental making the most of coffee and tea making facilities and a theme park, check out Westport Plaza and St. Louis Zoo.

Can I find studio apartments for rent in and around St. Charles?

Typically small in size, easy on the pocketbook and conveniently located, it's difficult not to succumb to the charms of a studio apartment. Make yourself comfortable in one of these vacation rentals and experience the culture of St. Charles up close:

  • Unpack your bags at "Premier Location: Heart Of The Italian Nbrhd". Amenities including air conditioning and outdoor furniture will help you feel right at home here.
  • "Shaw Guest Suite: Belle On Tower Grove Park" is another fabulous choice. Get comfortable and enjoy the use of a nearby laundromat, a TV and more.

When it's time to step foot outside your studio apartment and discover the highlights, there's plenty to keep you amused around St. Charles. Interested in cultural attractions? Swing by St. Louis Walk of Fame and Unity Theatre Ensemble.

Can I find short term rentals in or near St. Charles?

Just because you only have a few days off work doesn't mean you need to spend it in a boring hotel. Head off on vacation but still have the home comforts you love at one of these short-term rentals in or around St. Charles:

  • "Retro Ranch With Private Indoor Pool And Sauna St Louis" is near the center of St. Charles, so you'll have tons of things to keep you occupied. Find your way to notable sights like Gateway Arch and Busch Stadium when you're not making the most of your cozy rental.
  • Jump out of bed, make a coffee and then start planning what to see around "Shaw Guest Suite: Belle On Tower Grove Park". City Museum and St. Louis Zoo should be on your list if you stay at this top-rated vacation rental.

What are the best romantic weekend getaways in or near St. Charles?

Forget about roses and chocolates. Sometimes all you need is to escape for the weekend, just you and your sweetie. At Vrbo, we've got romantic getaways in and around St. Charles that would make Cupid green with envy. Here are some we think you'll love:

  • Around 16 miles from St. Charles, "Premier Location: Heart Of The Italian Nbrhd" is a perfect place for doting lovebirds. Beauty services and shopping facilities are among the many amenities you'll find here.
  • Alternatively, spend a few blissful days enjoying each other's company at "1790's Renovated Barn, Historic Main Street St. Charles", around 1 mile from St. Charles. A fireplace and air conditioning will help set the mood.

What are the best large group vacation rentals in or near St. Charles?

Peep these large group vacation rentals in or near St. Charles and don't worry about leaving anyone off your guest list:

  • A range of amenities including a kitchen and a swimming pool make "Rare New Treasure2 Homes+outdoor Gathering Area. Two Blocks From Main St" a group favorite. This getaway has 5 bedrooms and accommodates up to 22 people. From the heart of St. Charles, it's around 1 mile away to the north.
  • Invite up to 23 of your best friends to "Upscale Historic Main Sthuge Dining" and fill its spaces with love and laughter. This option has 3 bedrooms and is around 1 mile to the north of St. Charles. It's crammed with features to keep your group comfortable, such as a water park and a swimming pool.

What are the best houses for rent with a pool in or near St. Charles?

Nothing spells fun like a pool does. Grab your inflatable flamingo and browse these houses in or near St. Charles that come with this added bonus:

  • Treat your loved ones to a memorable stay at "Entire Dogtown House Near Zoo, Forest Park And Wash U". There's plenty to love about this retreat apart from its pool, such as towels and a dining table.
  • Spend lazy days splashing about or finding some peaceful moments beside the water at "317 4th Street · 4 Bedroom House". This vacation rental is also a firm favorite and features a fridge, towels and more.

St. Charles has a humid subtropical climate, with average summertime temperatures ranging from 70 ºF to 85 ºF. But you don't have to wait until summertime to visit. Take a look at the search bar at the top of the page and adjust the filters to find the ideal St. Charles vacation rental and organize your getaway for whenever you like.

What are the best large family vacation rentals in or near St. Charles?

Whether your ideal escape is up in the mountains or down by the beach, you'll enjoy it even more if you share the experience with loved ones. Choose one of these large family vacation rentals in or near St. Charles and bring the entire crew along:

  • Get everyone together at "Retro Ranch With Private Indoor Pool And Sauna St Louis", which has 4 bedrooms that sleep up to 10 guests. This retreat is located 13 miles to the south of St. Charles and features amenities such as a swimming pool and outdoor furniture.
  • Another top choice is "1870's Luxury Guest Cottage, Historic Downtown St. Charles". This large rental is 0.1 miles southwest of St. Charles and features childrens activities, on-site watersports and more. With 3 bedrooms accommodating up to 7 people, you won't need to leave anyone off your guest list.

When you want to get out and explore, there are plenty of family-friendly attractions in the area to keep everyone happy and entertained. St. Louis Zoo, Grants Farm and Six Flags St. Louis should be at the top of your agenda.

Can I find family cabin rentals in or near St. Charles?

Time spent with family is important, which is why we'll help you find a space where you can truly connect. Stay in one of these family cabin rentals in or near St. Charles and create wonderful new memories with the people you love:

  • "New ‘bross Brother's Cabin’ W" - This sought-after getaway offers childrens activities and a TV and is around 9 miles west of central St. Charles.
  • "Tiny Off Grid A - Frame Cottage" - Another awesome choice, this vacation rental comes with a barbecue grill, a kitchen and more. You'll find it around 9 miles to the north of St. Charles.

For more options, use the search bar at the top of the page and adjust the filters to find the St. Charles vacation rental that's perfect for your needs.

What are the best large houses to rent with indoor pools in or near St. Charles?

Add an extra touch of indulgence to your getaway by staying somewhere with an indoor pool. These large houses in or near St. Charles have a swimming space to call your own, along with loads of room for whoever is fortunate enough to be coming with you:

  • With 4 bedrooms that can sleep up to 10 guests, "Retro Ranch With Private Indoor Pool And Sauna St Louis" is the perfect place to reconnect with the people that matter most. Make use of this property's range of amenities, including a garden and a swimming pool.
  • Another outstanding option is "Multicolor Led Pool Rock Waterfall Hot Tub Getaway Large Home 8 Beds". With 3 bedrooms accommodating up to 8 guests, you can invite the whole gang to stay with you and swim. A kitchen and a swimming pool are other amenities your guests can enjoy here.

Use the search bar at the top of the page and adjust the filters to find more impressive St. Charles vacation rental options for your next big getaway.