Discover a selection of 91 vacation rentals in Palmetto Bluff, Bluffton that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and private pools. Prices start at $469 per night, and houses and cottages are popular options for a stay in Palmetto Bluff. Either way, you'll find a rental for everyone's needs.
Top rated rentals — Palmetto Bluff
Destination guide

Southern charm in Palmetto Bluff

Brimming with Southern charm, Palmetto Bluff is a luxury community on the banks of the May River. It's an enchanting slice of the South Carolina Lowcountry, with a big focus on showcasing the natural beauty of the region. There are a handful of vibrant villages to explore, a lively social scene to enjoy and plenty of opportunities to connect with nature. From beautifully restored cottages to luxury heritage homes, there's no better way to embrace the lifestyle than with Palmetto Bluff vacation rentals.

Things to do

Tee off at the May River Golf Course

Golfers will jump at the chance to tee off at the 18-hole May River Golf Course designed by the legendary Jack Nicklaus. Want to maximize your time on the green? Owned by locals, some Palmetto Bluff vacation rentals offer exclusive access to tee times and entry to the custom-designed clubhouse. Hunting is a long-standing tradition, so why not head down to the Palmetto Bluff Shooting Club? At the Wilson Lawn and Racquet Club you can enjoy a game of tennis or bocce, followed by a leisurely drink at the pavilion.


Wine and dine in Palmetto Bluff

From breezy cafes in Wilson Village to elegant bistros at the Montage Palmetto Bluff Resort, you'll be spoilt for choice when it comes to wining and dining. While afternoon G&Ts at the River House Lounge are a treat, nothing says relaxation quite like drinks on the porch of your Palmetto Bluff vacation rental property. You'll be immersed in a tightknit community, so you'll likely soon be clinking glasses with neighbors. Palmetto Bluff is laced with an extensive trail system, suitable for family walks and horseback rides. You can also rent kayaks and explore the water trails of the May River.


Celebrate summer in Palmetto Bluff

Summer is high season in Palmetto Bluff, when the community is brimming with locals and vacationers alike. Crowds peak from Memorial Day to Labor Day, with 4th of July fireworks, community oyster roasts and themed parades along the Village Green. Thanksgiving and Easter also fill up fast, so be sure to book Palmetto Bluff vacation rentals well in advance. With plenty of properties sleeping over 10 guests, it's easy to plan a multi-family getaway to Bluffton. There is no slowdown in the winter, when South Carolina enjoys mild weather and plenty of sunshine.

Natural features

Make a splash in the May River

Set along the May River, Palmetto Bluff is surrounded by maritime forests, saltmarshes and winding tidal creeks. The award-winning community covers a sprawling 20,000-acre footprint which makes it one of the largest waterfront properties on the East Coast. There are 32 miles of riverfront and coastline to explore, as well as ancient live oak trees and sabal palmetto palms to admire. The Palmetto Bluff Conservancy was founded to watch over the local ecosystem and ensure that it remains one of South Carolina's most biodiverse regions.

How many vacation rentals are available around Palmetto Bluff, Bluffton?

Our 2021 property listings offer a large selection of 91 vacation rentals around Palmetto Bluff. From 89 house rentals to 6 cottage rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

Can I rent Houses in Palmetto Bluff?

Yes, of course. Vrbo has 89 Houses in Palmetto Bluff. Our other popular types of vacation rentals in Palmetto Bluff include:

  • Cottages: 6 rentals available
  • Cabins: 6 rentals available
  • Bungalows: 6 rentals available

Can I find a vacation rental with pool in Palmetto Bluff?

Yes, you can select your preferred vacation rental with pool among our 85 vacation rentals with pool available in Palmetto Bluff. Please use our search bar to access the selection of vacation rentals available.