Discover a selection of 81 vacation rentals in Palmetto Bluff, Bluffton that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and kitchens. Prices start at $506 per night, and houses and cottages are popular options for a stay in Palmetto Bluff. Either way, you'll find a rental for everyone's needs.
Destination guide

Southern charm in Palmetto Bluff

Brimming with Southern charm, Palmetto Bluff is a luxury community on the banks of the May River. It's an enchanting slice of the South Carolina Lowcountry, with a big focus on showcasing the natural beauty of the region. There are a handful of vibrant villages to explore, a lively social scene to enjoy and plenty of opportunities to connect with nature. From beautifully restored cottages to luxury heritage homes, there's no better way to embrace the lifestyle than with Palmetto Bluff vacation rentals.

Things to do

Tee off at the May River Golf Course

Golfers will jump at the chance to tee off at the 18-hole May River Golf Course designed by the legendary Jack Nicklaus. Want to maximize your time on the green? Owned by locals, some Palmetto Bluff vacation rentals offer exclusive access to tee times and entry to the custom-designed clubhouse. Hunting is a long-standing tradition, so why not head down to the Palmetto Bluff Shooting Club? At the Wilson Lawn and Racquet Club you can enjoy a game of tennis or bocce, followed by a leisurely drink at the pavilion.


Wine and dine in Palmetto Bluff

From breezy cafes in Wilson Village to elegant bistros at the Montage Palmetto Bluff Resort, you'll be spoilt for choice when it comes to wining and dining. While afternoon G&Ts at the River House Lounge are a treat, nothing says relaxation quite like drinks on the porch of your Palmetto Bluff vacation rental property. You'll be immersed in a tightknit community, so you'll likely soon be clinking glasses with neighbors. Palmetto Bluff is laced with an extensive trail system, suitable for family walks and horseback rides. You can also rent kayaks and explore the water trails of the May River.


Celebrate summer in Palmetto Bluff

Summer is high season in Palmetto Bluff, when the community is brimming with locals and vacationers alike. Crowds peak from Memorial Day to Labor Day, with 4th of July fireworks, community oyster roasts and themed parades along the Village Green. Thanksgiving and Easter also fill up fast, so be sure to book Palmetto Bluff vacation rentals well in advance. With plenty of properties sleeping over 10 guests, it's easy to plan a multi-family getaway to Bluffton. There is no slowdown in the winter, when South Carolina enjoys mild weather and plenty of sunshine.

Natural features

Make a splash in the May River

Set along the May River, Palmetto Bluff is surrounded by maritime forests, saltmarshes and winding tidal creeks. The award-winning community covers a sprawling 20,000-acre footprint which makes it one of the largest waterfront properties on the East Coast. There are 32 miles of riverfront and coastline to explore, as well as ancient live oak trees and sabal palmetto palms to admire. The Palmetto Bluff Conservancy was founded to watch over the local ecosystem and ensure that it remains one of South Carolina's most biodiverse regions.

How many vacation rentals are available around Palmetto Bluff, Bluffton?

Our 2020 property listings offer a large selection of 81 vacation rentals around Palmetto Bluff. From 46 house rentals to 6 cottage rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

What is the best area to stay when traveling to Palmetto Bluff?

Whether you're traveling with family or friends, here are the areas with the largest selection of vacation rentals for a holiday trip or just for a weekend in Palmetto Bluff:

  • Sea Pines: 1,711 vacation rentals
  • South Forest Beach: 1,705 vacation rentals
  • North Forest Beach: 2,686 vacation rentals
  • Historic District - North: 761 vacation rentals
  • Historic District - South: 803 vacation rentals

For other neighborhoods, please use our search bar to access the selection of vacation rentals available.

What are the popular point of interests near where I can stay when traveling to Palmetto Bluff?

Vrbo offers a large selection of vacation rentals near lovely places in Palmetto Bluff. From Vrbo travelers, the top most popular points of interest to stay for a holiday trip or just for a weekend are:

  • May River Golf Club at Palmetto Bluff: 8,535 vacation rentals
  • Coligny Beach: 7,569 vacation rentals
  • Tybee Island Fishing Pier and Pavilion: 8,357 vacation rentals
  • Tybee Island Marine Science Center: 8,356 vacation rentals
  • North Beach: 1,074 vacation rentals

But there are many other points of interest around Palmetto Bluff listed on Vrbo where you can find your place to stay. Please use our search bar to access the selection of vacation rentals available near the point of interest of your choice.

Can I rent Houses in Palmetto Bluff?

Yes, of course. Vrbo has 46 Houses in Palmetto Bluff. Our other popular types of vacation rentals in Palmetto Bluff include:

  • Cottages: 6 rentals available
  • Cabins: 6 rentals available
  • Bungalows: 6 rentals available

But you can also enjoy a great stay in one of our other vacation rentals including Hotels and more.

Can I find a vacation rental with pool in Palmetto Bluff?

Yes, you can select your preferred vacation rental with pool among our 73 vacation rentals with pool available in Palmetto Bluff. Please use our search bar to access the selection of vacation rentals available.

Explore destinations around Palmetto Bluff

Sea Pines
1,711 vacation rentals
South Forest Beach
1,705 vacation rentals
North Forest Beach
2,686 vacation rentals
Historic District - North
761 vacation rentals
Historic District - South
803 vacation rentals
Heritage Woods
648 vacation rentals
674 vacation rentals
Melrose on the Beach
43 vacation rentals
Beach Institute
762 vacation rentals
Historic District
57 vacation rentals
Dixon Park
577 vacation rentals
Pigeon Point
64 vacation rentals
Yamacraw Village
576 vacation rentals
Old West Broad Neighborhood
743 vacation rentals
Kayton/Frazier Area
667 vacation rentals
The Old Commons
57 vacation rentals
The Old Point
53 vacation rentals
The Bluff
60 vacation rentals
355 vacation rentals
Mossy Oaks
22 vacation rentals