Discover a selection of 55 vacation rentals in Santee that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and air conditioning. Prices start at $119 per night, and cabins and houses are popular options for a stay in Santee. Either way, you'll find a rental for everyone's needs.
Top rated rentals — Santee
Destination guide

Unwind with a lakeside cabin rental in Santee

Santee, South Carolina, is a hidden gem alongside Lake Marion’s south shore. As the largest freshwater lake in the state, Lake Marion’s ample fishing and boating access draws visitors year-round. Verdant, rolling golf courses entice pros and amateurs alike, while the Santee Recreation Center and Waterpark offers a splashy haven to cool off with the family. If you’re planning a trip to a lush hideaway that’s rich with Southern charm, Santee vacation rentals run the gamut—from budget-conscious lodging and lakeside escapes to luxurious accommodations in a serene natural setting.

Things to do

Unmissable Santee attractions

Among the top Santee attractions, the Santee Recreation Center and Waterpark provides basketball courts, a bocce field, recreation pavilions, and an aquatics center with an 80,000-gallon pool separated into family-friendly sections. For year-round travelers, Santee’s fishing season never ends, and with Lake Marion right in town and bordering Lake Moultrie, there are more than 170,000 acres of waterways to enjoy. These lake systems have held world records for channel catfish and striped bass and also make for memorable hunting, birdwatching, and hiking. The Palmetto Trail is perfect for hikers and bikers alike. Six passages to this cherished state route lie right in Santee, extending 12 miles through agricultural lands where designated camping is encouraged.


Fun things to do in Santee

Lake Marion is the crown jewel of this waterside hamlet, and visitors relish the chance to go boating or angle away the afternoon. To participate in these Santee activities, equipment shops can outfit you for the day, while fishing enthusiasts can enjoy numerous competitions to expand their expertise. Santee has earned a reputation as “America’s Value Golf Destination.” If you’re working on your stroke or planning a bachelor party vacation, there are 3 deluxe yet affordable golf courses nearby. For nature lovers, Santee State Park boasts excellent birdwatching, a wildlife refuge, and swamp tours to get a feel for the South’s flora and fauna.


Weather forecasts in Santee

The Santee climate is largely mild, which means fishing and boating opportunities are open year-round. From summer to winter, the average temperature in Santee rarely breaks 80 degrees or dips below 50, making the outdoors easily enjoyable. Golfers, nature lovers, hunters, and anglers have access to Santee’s wildland all year, making Santee vacation rentals ideal to stay in with family and friends, or for events. Summer sunshine encourages lakeside fun, and even in the winter Santee’s vacation rentals provide a cozy, close-to-nature retreat.

Natural features

A lakeside getaway in Santee

Settled among the Santee River Valley, Santee’s natural splendor makes for a memorable visit to the South Carolina countryside. Lake Marion, nearby Lake Moultrie, and the countless swamps, creeks, and backwater ponds dominate the landscape and make for stunning aquatic sunsets. With Charleston a little over an hour away, Santee is in range of the Carolina coast and offers the best of both worlds—a natural getaway without compromising on entertainment. The Santee National Wildlife Refuge is a sight to behold, with birdwatchers flocking to spot waterfowl species unique to the mid-Atlantic.

How to get there

Transportation to and around Santee

Fly into Columbia, SC (CAE-Columbia Metropolitan), the closest airport, located 49 mi (78.8 km) from the city center.

How many vacation rentals are available around Santee?

Our 2021 property listings offer a large selection of 55 vacation rentals around Santee. From 2 cabin rentals to 41 house rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.