Discover a selection of 96 vacation rentals in Santee, SC that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and air conditioning. Prices start at $121 per night, and houses and cabins are popular options for a stay in Santee. Either way, you'll find a rental for everyone's needs.
Top rated rentals — Santee
Destination guide

The friendly area of Santee awaits your stay

The lake and surrounding scenery provide a peaceful ambiance to your vacation home in Santee. Travelers to this welcoming city praise the restaurants, golfing and fishing. Whether you're planning a family vacation, friends trip or romantic retreat, HomeAway has a great selection of vacation homes. Many rentals come with a full kitchen and separate dining area, perfect if you need a space for entertaining.

Things to do

Unmissable Santee attractions

Among the top Santee attractions, the Santee Recreation Center and Waterpark provides basketball courts, a bocce field, recreation pavilions, and an aquatics center with an 80,000-gallon pool separated into family-friendly sections. For year-round travelers, Santee’s fishing season never ends, and with Lake Marion right in town and bordering Lake Moultrie, there are more than 170,000 acres of waterways to enjoy. These lake systems have held world records for channel catfish and striped bass and also make for memorable hunting, birdwatching, and hiking. The Palmetto Trail is perfect for hikers and bikers alike. Six passages to this cherished state route lie right in Santee, extending 12 miles through agricultural lands where designated camping is encouraged.


Fun things to do in Santee

Lake Marion is the crown jewel of this waterside hamlet, and visitors relish the chance to go boating or angle away the afternoon. To participate in these Santee activities, equipment shops can outfit you for the day, while fishing enthusiasts can enjoy numerous competitions to expand their expertise. Santee has earned a reputation as “America’s Value Golf Destination.” If you’re working on your stroke or planning a bachelor party vacation, there are 3 deluxe yet affordable golf courses nearby. For nature lovers, Santee State Park boasts excellent birdwatching, a wildlife refuge, and swamp tours to get a feel for the South’s flora and fauna.


Weather forecasts in Santee

The Santee climate is largely mild, which means fishing and boating opportunities are open year-round. From summer to winter, the average temperature in Santee rarely breaks 80 degrees or dips below 50, making the outdoors easily enjoyable. Golfers, nature lovers, hunters, and anglers have access to Santee’s wildland all year, making Santee vacation rentals ideal to stay in with family and friends, or for events. Summer sunshine encourages lakeside fun, and even in the winter Santee’s vacation rentals provide a cozy, close-to-nature retreat.

Natural features

A lakeside getaway in Santee

Settled among the Santee River Valley, Santee’s natural splendor makes for a memorable visit to the South Carolina countryside. Lake Marion, nearby Lake Moultrie, and the countless swamps, creeks, and backwater ponds dominate the landscape and make for stunning aquatic sunsets. With Charleston a little over an hour away, Santee is in range of the Carolina coast and offers the best of both worlds—a natural getaway without compromising on entertainment. The Santee National Wildlife Refuge is a sight to behold, with birdwatchers flocking to spot waterfowl species unique to the mid-Atlantic.

How to get there

Transportation to and around Santee

The nearest airport is in Columbia Metropolitan Airport (CAE), located 49 mi (78.8 km) from the city center.

What are the top vacation rentals in or near Santee?

The heart wants what the heart wants, and right now it wants to take a vacation. It's time to pack your bags and retreat to one of these top vacation rentals in or near Santee:

  • "Beautiful Lake Condo Santee Sc" is a popular choice. Around 1 mile from Santee, it has 2 bedrooms and plenty of handy amenities, including a balcony and a stovetop.
  • "Lakefront Condo With Boat Slip Available. 3 Br" also promises a memorable getaway, offering 3 bedrooms, a dishwasher, a TV and more. It's around 1 mile from Santee.

For even more great options, use the search bar at the top of the page to find the perfect Santee vacation rental for you.

What are the top-rated vacation rentals for weekend getaways in or near Santee?

If you've been busier than an ant at a picnic lately, you deserve to escape for a couple of glorious days. Leave the office early on Friday and head for one of these weekend getaways in or near Santee:

  • Whisk yourself away to "Quaint 2 Bedroom Condo". Located about 1 mile to the northeast of Santee, this cozy escape has everything you need for a relaxing stay, including an outdoor pool and a TV.
  • Alternatively, make new memories with your favorite people at "Executive 2 Br/2 Ba Lakefront Corner Suite Condo", which is around 1 mile to the northeast of Santee. You'll have use of a hair dryer, a kitchen and more here.

Can I find studio apartments for rent in and around Santee?

Studio apartments may be small, but they pack a mighty punch when it comes to convenience and location. Put your bags down at one of these top studio apartments in or near Santee:

  • After a big day of urban exploration, kick back and relax at "Beautiful 2 Bedroom Unit At Resort". A washing machine and a private pool are among the amenities on offer here.
  • Another top rental is "Charming Furnished Apartment". Don't be fooled by its compact size — this cozy apartment is filled with useful amenities like a living room, nearby hunting activities and plenty more.

Can I find short term rentals in or near Santee?

From cozy studio apartments to large vacation rentals, Vrbo has your mini break sorted. Here are just two of our popular picks in and around Santee:

  • If you can only spare a couple of nights, "Serenity At Santee" is a good choice. It's not too far from the center of Santee, so you'll be near lots of attractions.
  • "The Blue Canoe Lodge - The Perfect Destination For Family" is also ideally located. Settle in here and discover why many guests rate this property as one of their favorites.

What are the best romantic weekend getaways in or near Santee?

Nothing says "I love you" like a romantic weekend trip. If you're eager to spend a couple of nights away with your beloved, we've got some romantic getaways in and around Santee that will sweep you off your feet:

  • Located around 1 mile from Santee, "Beautiful Lake Condo Santee Sc" is an ideal place for doting lovebirds. Air conditioning and a balcony are some of the amenities you'll find here.
  • "Lakefront Condo With Boat Slip Available. 3 Br" is another wonderful option that'll impress. It's approximately 1 mile from Santee and has air conditioning and a dining table.

What are the best large group vacation rentals in or near Santee?

Big groups mean big fun. They also mean finding someplace that'll easily fit your whole gang. Check out our large group vacation rentals in or around Santee and get your loved ones together under one roof:

  • Offering space, comfort and privacy, you'll get your guests' seal of approval at "Courtney House On Lake Marion". Up to 12 people can stay at this property which has 5 bedrooms, a firepit and a kitchen. This group getaway is around 11 miles to the southeast of Santee.
  • Invite up to 14 of your friends to "Large 4 Bedroom In Gated Golf Community On Scenic Cove Off Lake Marion With Pool" and fill its spaces with love and laughter. This top option has 4 bedrooms and is around 2 miles to the east of central Santee. It's crammed with features to keep large groups comfortable and content, such as a kitchen and a nearby waterfront.

What are the best houses for rent with a pool in or near Santee?

Of all the conveniences a vacation rental can offer, a pool is one of the most coveted. Check out these houses for rent with a pool in or near Santee and spend your days splashing about. Just remember to take your flamingo floatie:

  • Pack your swim gear and take your gang to "Courtney House On Lake Marion". There are plenty of other convenient amenities here, including childrens activities and a DVD player.
  • Spend lazy vacation days splashing around or enjoying peaceful moments beside the water at "The Lake House At Turtle Cove: Cozy Relaxing Lake Home With Dock On Wooded Lot". This property is also a firm favorite and offers childrens activities, a toaster and more.

Not sure what to pack for your Santee escape? This leading destination has a humid subtropical climate. In the summertime, expect average temperatures of between 70 ºF and 90 ºF. Browse our selection of Santee vacation rentals by using the search bar at the top of the page. Simply adjust the filters to get more inspiration on where to stay.

What are the best large family vacation rentals in or near Santee?

Whether you're traveling with a small group or you're taking your long-lost relatives along, family vacations equal fun. These large rentals in and around Santee have space for everybody — and everything you need to keep them all happy:

  • Make your visit a memorable one at "The Blue Canoe Lodge - The Perfect Destination For Family". This getaway has 4 bedrooms, can fit up to 10 guests and features plenty of amenities, including a TV and childrens activities. You'll find it around 8 miles southeast of Santee.
  • "Courtney House On Lake Marion" is another vacation rental the whole team will love. Invite up to 12 friends and family to this retreat which comes with 5 bedrooms, childrens activities, a foosball table and more. It's located 11 miles to the southeast of central Santee.

As tempting as it is, don't spend your entire vacay socializing indoors. Get out and explore the area's family-friendly attractions, beginning with Edisto Memorial Gardens.

Can I find two-bedroom vacation rentals in or near Santee?

Yes you can. From modern apartments to comfy cabin retreats, Vrbo is your one-stop-shop for rental places. Families or small groups will like these two-bedroom properties in or near Santee:

  • "Beautiful Lake Condo Santee Sc" is a perfect choice for small groups and families. In addition to two bedrooms, this delightful stay offers amenities like a swimming pool and a kitchen.
  • "Quaint 2 Bedroom Condo" is another terrific two-bedroom option in the Santee area. It has amenities like a swimming pool and a kitchen.

Are there vacation rentals with fire pits in or near Santee?

Whether you want to enjoy a glass of vino beside the flames with your boo or just stay warm after the sun goes down, we'll help you find a vacation rental with a fire pit. Check out a couple of our favorite options in or near Santee:

  • Chat, laugh and sing with the ones you love around the fire at "Executive 2 Br/2 Ba Lakefront Corner Suite Condo". This escape comes with plenty of other top amenities, including a garden and a kitchen.
  • Light a blaze and then enjoy the tranquil vibe at "The Blue Canoe Lodge - The Perfect Destination For Family". This inviting escape also offers a kitchen and a nearby waterfront.