Discover a selection of more than 10,000 vacation rentals in South Carolina Lowcountry that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and WiFi. Prices start at $115 per night, and houses and cottages are popular options for a stay in South Carolina Lowcountry. Either way, you'll find a rental for everyone's needs.
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Top rated rentals — South Carolina Lowcountry
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How many vacation rentals are available around South Carolina Lowcountry?

Our 2021 property listings offer a large selection of 11,245 vacation rentals around South Carolina Lowcountry. From 7,207 house rentals to 369 cottage rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.