Discover a selection of 2,000 vacation rentals in Upcountry South Carolina, US that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including WiFi and swimming pools. Prices start at $89 per night, and cabins and cottages are popular options for a stay in Upcountry South Carolina. Either way, you'll find a rental for everyone's needs.
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Top rated rentals — Upcountry South Carolina
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How many vacation rentals are available around Upcountry South Carolina, US?

Our 2021 property listings offer a large selection of 2,093 vacation rentals around Upcountry South Carolina. From 414 cabin rentals to 406 cottage rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.