Discover a selection of 60 vacation rentals in Upcountry South Carolina, US that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including WiFi and swimming pools. Prices start at $75 per night, and houses and cabins are popular options for a stay in Upcountry South Carolina. Either way, you'll find a rental for everyone's needs.
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Top rated rentals — Upcountry South Carolina
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Destination guide

Book a vacation rental for your Upstate South Carolina getaway

Experience the unique character of Upstate South Carolina with a stay in a vacation home rental. There's no shortage of things to see and do in the area.If you need more space to accommodate a family vacation or friends trip, rental homes often come with separate dining areas and spacious living rooms.

Things to do

Activities and attractions in and around Upstate South Carolina

Do you want to discover attractions to visit in the area? Venture out of your vacation home and experience everything that makes Upstate South Carolina a fun place to get away. These are some of the top attractions to explore, all within 30 miles (48.2 km) of the city center:

  • Discovery Island Water Park (2.5 mi / 4 km)
  • Heritage Park (2.7 mi / 4.4 km)
  • Frankie's Fun Park (7.7 mi / 12.4 km)
  • Topgolf (10.1 mi / 16.3 km)
  • Greenville Zoo (11.2 mi / 18.1 km)
  • Lakeside Park (9.6 mi / 15.5 km)
Natural features

Exploring the natural features in Upstate South Carolina

Whether you're looking for fun outdoor activities or just want to appreciate the scenery, Upstate South Carolina is a great place to get outside. Here are some of the area’s noteworthy sights, all within 30 miles (48.2 km) of the city center:

  • Heritage Park (2.7 mi / 4.4 km)
  • Falls Park on the Reedy (11.5 mi / 18.6 km)
  • Swamp Rabbit Trail (14 mi / 22.6 km)
  • Tyger River Park (14.8 mi / 23.8 km)
  • Paris Mountain State Park (17.3 mi / 27.8 km)
  • 295 Sports Complex (26.2 mi / 42.2 km)
How to get there

Transportation options to and around Upstate South Carolina

Fly into Greenville-Spartanburg Intl. Airport (GSP), the closest airport, located 12.9 mi (20.7 km) from the city center.

If you're traveling by train, Greenville Station, Spartanburg Station and Clemson Station are the main stations in the city.

What are the top vacation rentals in Upcountry South Carolina?

From luxury houses to simple cottages, Vrbo has properties to fit all budgets and tastes. Here are some of the top vacation rentals in Upcountry South Carolina:

  • "7 Mi From Clemson, 5000 Square Ft Lake House": If you're chasing a comfy living space in Seneca, make yourself cozy here. It comes with 4 bedrooms and amenities like heating and a dining table.
  • "Spacious Lake Hartwell Home With Cozy Cabin Appeal": Put your bags down and your weary feet up at this top option in Seneca. It comes with 3 bedrooms, a dryer, a boat and more.

For even more great options, use the search bar at the top of the page to find the perfect Upcountry South Carolina vacation rental for you.

What are the best tiny house vacation rentals in Upcountry South Carolina?

You need only set foot in one of Vrbo's tiny house vacation rentals in Upcountry South Carolina to find out that good things really do come in tiny packages. Ingeniously designed to maximize every spare inch of space, these fun-sized digs promise a big vacation experience:

  • Take a few days off to recharge at "Cottage/tiny House Living Accommodation In Beaufort For Cost". Located in Pigeon Point, cookware, dishware and utensils and heating are just two of the amenities offered here.
  • "New Boutique Tiny Home On The Saluda River" comes with plenty of conveniences, such as heating and a firepit. Located in Easley, you'll be able to live large in this small yet comfy property.

Can I find log cabins to rent in Upcountry South Carolina?

There's something delightfully cozy about relaxing in a log cabin with a hot chocolate and a novel. Leave the hustle and bustle of life behind and spend a few nights at one of these log cabins in Upcountry South Carolina:

  • Settle in at "Awesome Lakefront Log Cabin With Covered Dock" in Seneca and during the day enjoy rafting and horse riding and your nights relaxing in your cozy cabin.
  • Another excellent choice is "Modern Log Cabin With Beautiful Views Of Lake Keowee Near Clemson". With fun activities like cycling and fishing nearby, this Seneca retreat will be ideal if you love the outdoors.

What are the top-rated vacation rentals for weekend getaways in Upcountry South Carolina?

Whether you're planning a family get-together, a romantic break or a couple of nights away on your own, we have weekend getaways in Upcountry South Carolina to suit. Pack a bag and stay at one of these favorite escapes:

  • "Luxury Townhome On Lake Keowee At Stoneledge" - This vacation rental in West Union offers amenities that'll make your visit comfortable, such as an iron and ironing board and tennis. Its handy location also makes it a good base to get out and do some sightseeing.
  • "Peaceful Retreat - - - Perfect Location" - This is another terrific place where you can relax and unwind and enjoy a mini break. Take advantage of heating, a washing machine and more during your short but memorable stay at this West Union property.

Can I find studio apartments for rent in Upcountry South Carolina?

If you're chasing something a little more personal than a standard hotel room, you'll like our studio apartments in Upcountry South Carolina. Whip up a snack in your kitchenette, watch TV on the lounge and feel completely at home. Take a peek at some of our top-rated studios:

  • Nap, eat, chill out ... Do it all from the compact yet smartly designed single room space at "Fantastic Main St Location With Huge Bedroom". Located in Greenville Downtown, a smart TV and an elevator are available here.
  • Alternatively, use "Cabin - Peace - In - The - Forest Retreat" as a base to explore the area. This home away from home is in Easley and offers cable/satellite TV services and a stovetop.

Can I find short term rentals in Upcountry South Carolina?

Upcountry South Carolina has short-term rentals that come in all sizes, shapes and budgets. Take a quick break in a cozy cabin, a deluxe condo or whatever else floats your boat. Below are two popular options to start you off:

  • "Luxury Townhome On Lake Keowee At Stoneledge" in West Union is ideal for a short-term stay. It's close to the center of town, so you can see all the best sights without having to travel too far.
  • Another excellent option is "Peaceful Retreat - - - Perfect Location" in Greenville. Whether you're on a quick stopover or enjoying a few days away, this vacation rental will make you feel right at home.

What are the best romantic weekend getaways in Upcountry South Carolina?

Whether you've been paired up for a month, a decade or forever, nothing beats a romantic weekend getaway to keep passions burning. If you're looking for someplace idyllic to spend a couple of days with your boo, you'll fall headfirst for these retreats:

  • Catch up on quality time and cuddles at "7 Mi From Clemson, 5000 Square Ft Lake House" in Seneca. A fireplace and air conditioning are among the little touches on offer here.
  • Alternatively, organize a loved-up weekend break at "Spacious Lake Hartwell Home With Cozy Cabin Appeal". Located in Seneca, it offers a fireplace, air conditioning and other bonuses.

What are the best houses for rent with a pool in Upcountry South Carolina?

In Upcountry South Carolina, you'll find plenty of house rentals where you can make every day a pool day. Having a splashing great time will be your highest priority at one of these superb retreats:

  • Welcome to "7 Mi From Clemson, 5000 Square Ft Lake House", where the first item on your agenda should be pool time. This escape is located in Seneca and offers a range of family-friendly amenities, including a toaster and outdoor furniture.
  • Unwind by the water while the kids splash about at "Lake House Near Clemson, Priv. Dock". This option in Seneca features a range of conveniences to keep your team nice and comfortable, such as a toaster and a garden.

What are the best large family vacation rentals in Upcountry South Carolina?

Start sending out those invites, because there are plenty of large family vacation rentals in Upcountry South Carolina that'll welcome your gang. Here are a few favorites:

  • Located in Seneca, "7 Mi From Clemson, 5000 Square Ft Lake House" has 4 bedrooms and can sleep up to 11 guests. A few of the handy amenities here include a kitchen and coffee and tea making facilities.
  • Another popular option, "Spacious Lake Hartwell Home With Cozy Cabin Appeal" in Seneca offers 3 bedrooms and accommodates up to 10 people. On-site watersports and childrens activities will help keep everyone feeling more than comfortable.

Can I find family cabin rentals in Upcountry South Carolina?

Booking a cabin rental in Upcountry South Carolina is an ideal excuse to get the family together. Rally the troops and check out these great options:

  • "Cabin - Private Romantic Mountain Getaway" - Book in a weekend at this escape in Pickens. Amenities like a barbecue grill and coffee and tea making facilities will help make your stay extra comfy.
  • "Cabin - Peace - In - The - Forest Retreat" - Craft magic memories with the kids at this popular cabin. Located in Easley, it provides guests with nearby birdwatching activities, a DVD player and more.

For more options, use the search bar at the top of the page and adjust the filters to find the Upcountry South Carolina vacation rental that's perfect for your needs.