Discover a selection of 360 vacation rentals in Lake Keowee that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and WiFi. Prices start at $192 per night, and houses and cabins are popular options for a stay in Lake Keowee. Either way, you'll find a rental for everyone's needs.
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Top rated rentals — Lake Keowee
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Destination guide

You'll be happier than a pig in mud at Lake Keowee

Just over yonder from foothills of the world-famous Blue Ridge Mountains, you'll find picturesque Lake Keowee, a man-made reservoir that’s popular with locals and visitors alike. Lake Keowee vacation rentals are a perfect starting point to explore the entire region, and you can take advantage of the seemingly endless water sports right outside your door, where you can fish and play on the lake ‘till your heart’s content. Take in some Clemson Country NCAA games, check out the area’s antique shops and markets, or see more than 500 classic cars during the annual Blue Ridge Fest each May.

Things to do

You're gonna be happier than a seagull with a french fry

Besides beautiful Lake Keowee itself, you can visit the waterfalls at Keowee-Toxaway State Park and Oconee Station State Historical Site, along with their interpretation centers. There’s a waterwheel-operated grist mill over yonder, plus the Pickens County Museum of Art and History. Architecture buffs will enjoy checking out the 19th-century Ashtabula Historic House, or the 18th-century Walnut Grove Plantation, 70 miles east. You can hit the BMW Zentrum Museum along the way. With so many things to experience, it’s no wonder Lake Keowee vacation rentals tend to book up quickly.

Activities

Do whatever suits your fancy in Lake Keowee

Lake Keowee vacation rentals are popular due to the area’s wealth of recreational opportunities. You can sit a spell and go fishing, or take your own sweet time while visiting the area’s small towns, which offer antique shopping, arts and crafts, seasonal Farmer’s Markets, and several golf courses. Take in a live theater performance, or a NCAA game at Clemson University, or just enjoy the lake where fun includes kayaking, boating, waterskiing and wakeboarding. And you'll want to attend a pig pickin' or a fish fry, along with the popular Blue Ridge Fest sporting over 500 vintage cars.

Weather

Only in the south where you use heat and a/c in the same day

Sporting 220 days of sunshine annually, Lake Keowee offers 4 seasons with generally mild temperatures year round. Summer is the most popular time to visit as temperatures peak in the low 70s, making it ideal for outdoor lovers to enjoy the area, but viewing the spectacular crimson and gold colors during the fall, make leaf turning season near as attractive, we reckon. But, you'll find the lowest prices when booking Lake Keowee vacation rentals during the winter months, when temperatures dip down to a still pleasant 49°F, so bring your sweater, and you'll be good to go.

Natural features

Get your fruit fix in 'the place of the mulberries'

Set down the road a bit from the nearby towns of Seneca and Clemson, Lake Keowee is about 36 miles over yonder from Greenville. Lake Keowee means ‘place of the mulberries’ in Cherokee, and you can pick them along it’s 300 miles of shoreline. The lake is home to plenty of waterfowl, hummingbirds and thrushes, along with snakes and several turtle species. There are tons of plants and wildflowers, including poison ivy, so be careful when you’re out and about, or you’ll end up madder than a wet hen. And don't miss the South Carolina Botanical Gardens.

How many vacation rentals are available around Lake Keowee?

Our 2021 property listings offer a large selection of 360 vacation rentals around Lake Keowee. From 300 house rentals to 41 cabin rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.