Discover a selection of 475 vacation rentals in Seneca, SC that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and kitchens. Prices start at $350 per night, and houses and cabins are popular options for a stay in Seneca. Either way, you'll find a rental for everyone's needs.
Destination guide

Travel to friendly Seneca

The lake and other outdoor surroundings create an inviting atmosphere in Seneca. Well-liked for its sporting events, university setting and boating, this city is both welcoming and scenic. Whether you're planning a family holiday, romantic stay or friends trip, vacation rentals offer features like full kitchens and laundry facilities for a more convenient stay.


Sightseeing in and around Seneca

Are you hoping to find things to do during your stay? Venture out of your vacation home and experience everything that makes Seneca a fun place to get away. Here are some of the most popular attractions to see, all within 30 miles (48.2 km) of the city center:

  • Walker Golf Course (6.4 mi / 10.4 km)
  • Keowee Key (10.3 mi / 16.6 km)
  • Easley Skate Center (21.2 mi / 34.1 km)
  • Cateechee Golf Club (25.2 mi / 40.5 km)
Natural features

Exploring the natural landscape of Seneca

Whether you're an adventurous traveler or just want to take in the scenery, Seneca is a great spot to appreciate mother nature. Here are a few of the area's most enchanting sights, all within 30 miles (48.2 km) of the city center:

  • South Carolina Botanical Gardens (7.4 mi / 11.9 km)
  • Lake Keowee (9.3 mi / 15 km)
  • Tugaloo Park (14.6 mi / 23.5 km)
  • Lake Hartwell (15.2 mi / 24.5 km)
  • Oconee State Park (15.3 mi / 24.6 km)
  • Devils Fork State Park (18.5 mi / 29.8 km)
How to get there

Traveling to and around Seneca

The nearest airport is in Greenville, SC (GSP-Greenville-Spartanburg Intl.), located 44.2 mi (71.1 km) from the city center.

How many vacation rentals are available around Seneca, SC?

Our 2020 property listings offer a large selection of 475 vacation rentals around Seneca. From 340 house rentals to 56 cabin rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

Can I rent a lakefront property in Seneca?

If you're longing for a peaceful pause, you need to spend some time lakeside. You'll feel like you're at adult summer camp — no collective singing Kumbaya required. Vrbo has 318 rental properties close to lakes available. Open to other ideas? Vrbo has stacks more options to explore, including:

  • 201 lake-view vacation rentals.
  • 164 shore-front vacation rentals.
  • 146 water-view vacation rentals.

Can I rent a house in Seneca?

Forget about uninspiring hotel-chain rooms. Our house vacation rentals offer a personal touch — as well as all the space you could ask for! There are 348 options currently available on Vrbo. Prices start from $100 per night. Or perhaps you'd rather one of the area's other popular lodging types, such as:

  • Cabin: 39 vacation homes. Prices start from $75 per night.
  • Condo: 38 vacation homes. Prices start from $97 per night.
  • Townhome: 21 vacation homes. Prices start from $126 per night.

Can I stay in Seneca in a large group?

The recipe for the perfect getaway is catching up with friends and relatives in an entirely new place. If you're traveling with a large group, Vrbo has options. House vacation homes are the top choice here for big groups of guests. Our international database currently has 79 available. Rental accommodations around here that are suitable for large groups include:

  • Looking for vacation homes that can hold 8 guests? We have 330 that will be ideal. The prices start from $107 per night.
  • After a vacation property for 10 people? We have 246 that will suit. Prices begin at just $120 a night.
  • Seeking vacation rentals to suit 6 guests? You'll be pleased to learn we have 231 that'll be perfect. You can get one for as little as $60 a night.

You and your crew will be more than satisfied when you arrange your Seneca escape through us!

Where are the cheapest rentals in Seneca?

Vrbo is here to help you catch up with your closest friends and family. Offering a selection of value-for-money rentals, you're sure to score an incredible hideout to suit everyone's tastes. Serenity Bay is perfect for bargain hunters. And with 10 Vrbo rentals at an average price of $342 a night, it isn't difficult to see why. Another 9 Vrbo rentals are on offer in or around Northlake Estates. With an average price of $345 a night, you're sure to grab a deal worth bragging to your friends about.

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