Discover a selection of 417 vacation rentals in Seneca, SC that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and WiFi. Prices start at $130 per night, and houses and cabins are popular options for a stay in Seneca. Either way, you'll find a rental for everyone's needs.
Top rated rentals — Seneca
Destination guide

The friendly city of Seneca awaits you

The lake and surrounding scenery provide a peaceful ambiance to your vacation home in Seneca. Well-liked for its sporting events, university setting and boating, this city is both welcoming and scenic. Are you looking for specific amenities for your getaway? Many of our vacation rentals feature full kitchens and laundry facilities.

Things to do

Activities and attractions in and around Seneca

Do you want to discover things to do in the city? Although it can be tempting to stay in your comfortable vacation rental, you'll want to check out everything that Seneca has to offer. These are some of the most popular attractions to explore, all within 30 miles (48.2 km) of the city center:

  • Walker Golf Course (6.4 mi / 10.3 km)
  • Keowee Key Golf Course (10.3 mi / 16.5 km)
  • Ultimate Action Sports (15.8 mi / 25.4 km)
  • Georgia Visitor Information Center - Lavonia (16.4 mi / 26.4 km)
  • Cateechee Golf Club (25.2 mi / 40.5 km)
Natural features

Exploring the natural landscape of Seneca

Whether you're looking for fun outdoor activities or just want to appreciate the scenery, Seneca is a great place to get outside. Here are a few of the area's most stunning sights, all within 30 miles (48.2 km) of the city center:

  • Lake Keowee (9.3 mi / 14.9 km)
  • Lake Hartwell State Park (13.8 mi / 22.3 km)
  • Oconee State Park (15.3 mi / 24.6 km)
  • Lake Hartwell (15.5 mi / 25 km)
  • Devils Fork State Park (18.5 mi / 29.7 km)
  • Lake Jocassee (20.5 mi / 33 km)
How to get there

Traveling to and around Seneca

The nearest airport is in Greenville-Spartanburg Intl. Airport (GSP), located 44.1 mi (71 km) from the city center.

What are the top vacation rentals in or near Seneca?

Whether you're looking for an intimate escape for you and your boo or somewhere spacious to fit friends and family, you'll find some top vacation rentals in and around Seneca. Here are a couple to get your inspiration flowing:

  • Make use of conveniences like a restaurant dining guide and free toiletries at "7 Mi From Clemson, 5000 Square Ft Lake House". Located around 2 miles from Seneca, this unique property has 4 bedrooms and good guest reviews.
  • Alternatively, make yourself comfy at "Spacious Lake Hartwell Home With Cozy Cabin Appeal". Located around 6 miles from the heart of Seneca, it has 3 bedrooms and features a microwave oven and a restaurant dining guide.

For even more great options, use the search bar at the top of the page to find the perfect Seneca vacation rental for you.

Can I find log cabins to rent in or near Seneca?

Whether you're after a modest retreat or something with a few more bells and whistles, you'll find a nice selection of log cabins to rent in Seneca. Experience adventure and comfort at one of these options:

  • If you want to try horse riding or mountain biking while you're staying in Seneca, "Awesome Lakefront Log Cabin With Covered Dock" in Seneca will be a terrific choice.
  • Alternatively, get into vacation mode at "Modern Log Cabin With Beautiful Views Of Lake Keowee Near Clemson". Try some windsurfing or water skiing or just take it easy at this Seneca property.

What are the top-rated vacation rentals for weekend getaways in or near Seneca?

We all need an escape from daily life every once in a while. If you're ready to spend a couple of mornings lounging around with a cup of coffee and a good book, there's no shortage of wonderful weekend getaways in and near Seneca. Check out two of our favorites:

  • Get comfortable at "Luxury Townhome On Lake Keowee At Stoneledge". Located around 5 miles to the north of Seneca, this cozy retreat has everything you need for a relaxing stay, including a living room and a free nearby fitness center.
  • Alternatively, fling a few clothes in a suitcase and set out for "Awesome Lakefront Log Cabin With Covered Dock". This popular getaway is about 6 miles north of Seneca and has a balcony and a boat.

Can I find studio apartments for rent in and around Seneca?

Absolutely. If you're hunting down a simple yet stylish stay, you can't go past a studio apartment. These compact properties exude charm and are often located in the center of town. We suggest the following options in or near Seneca:

  • After a fun-filled day of urban exploration, relax in total comfort at "Lake View Cottage - Gorgeous Sunsets". A firepit and nearby birdwatching activities are among the handy amenities you'll find here.
  • "Boutique Hotel In Historic Downtown Seneca - Room #6" is another top choice, providing all you could need for a fabulous Seneca vacation. Useful amenities here include heating and a TV.

Can I find short term rentals in or near Seneca?

From chic apartments to spacious homes, Vrbo has your mini vacation sorted. Here are just two of our favorite picks in and around Seneca:

  • Close to the center of Seneca, "Easy Access Lake Front With Beach" lays out the welcome mat for short-term guests. When you're not chilling out in your comfortable digs, get out and explore everything that's around you.
  • Another fantastic option is "Pristine Views From Lakefront Home". Gather a few friends and enjoy a relaxing stay close to the heart of Seneca.

What are the best romantic weekend getaways in or near Seneca?

Nothing says "I love you" quite like a romantic weekend together. If you're longing to spend a couple of evenings away with your honey, we've got some romantic getaways in and around Seneca that will sweep you off your feet:

  • Slip away on Friday for a couple of passionate nights at "7 Mi From Clemson, 5000 Square Ft Lake House". Located around 2 miles from Seneca, this place comes with plenty of nice touches, including a fireplace and a balcony.
  • "Spacious Lake Hartwell Home With Cozy Cabin Appeal" is another top option that's guaranteed to impress. It's approximately 6 miles from Seneca and comes with a fireplace and air conditioning.

What are the best houses for rent with a pool in or near Seneca?

A pool is often a must-have when choosing where to stay, especially if you're getting away with the kids. Browse these houses with a pool in or near Seneca and fill your days with frolicking good fun:

  • Round up your crew and enjoy an unforgettable stay at "7 Mi From Clemson, 5000 Square Ft Lake House". There's plenty to love about this getaway apart from its pool, such as coffee and tea making facilities and a living room.
  • "Lake House Near Clemson, Priv. Dock" is the type of place you go to get away from the everyday and appreciate your surroundings, starting with its glorious pool. A toaster and a stereo are also on hand to make your stay a memorable one.

Not sure how to pack your suitcase for your Seneca getaway? This leading destination has a humid subtropical climate. In the summertime, you can expect average temperatures of between 65 ºF and 90 ºF. Check out our range of Seneca vacation rentals by using the search bar at the top of the page. Simply adjust the filters to get more great ideas about where to stay.

What are the best large family vacation rentals in or near Seneca?

The first phase of any big family trip is searching for the ideal place to stay. Whether you're organizing a fun-filled escape with the kids or a catch-up with lots of relatives, Vrbo has large family vacation rentals in and around Seneca with plenty of space for everyone. Here are two popular options worth a look:

  • With 4 bedrooms that sleep as many as 11 guests, "7 Mi From Clemson, 5000 Square Ft Lake House" has enough space to truly connect with family and friends. It's around 2 miles north of Seneca and comes with amenities designed to keep groups comfortable, such as a toaster and a balcony.
  • "Spacious Lake Hartwell Home With Cozy Cabin Appeal", around 6 miles to the south of central Seneca, was made for family vacations. As many as 10 of your favorite people can fit into this welcoming rental which has 3 bedrooms, a balcony, a porch and more.

If you're looking for family-friendly attractions in the area, Yellow Branch Falls promises a great day out for young and old.

Can I find family cabin rentals in or near Seneca?

Time spent with family is important, which is why we'll help you find a place where you can truly connect. Book one of these family cabin rentals in or near Seneca and make memories with the ones you love:

  • "Cabin At Beautiful Lake Jocassee" - Enjoy precious time with your gang at this escape, which is around 18 miles north of central Seneca. A microwave oven and on-site watersports are among its family-friendly amenities.
  • "Cabin - New Seneca Creek Hideaway | Hot Tub | Bar And Game Room | Close To Lakes And Clemson" - This property is another favorite with families and is around 4 miles northeast of Seneca. Offering a dining table, beach sun loungers and more, it'll get your group's stamp of approval.

For more options, use the search bar at the top of the page and adjust the filters to find the Seneca vacation rental that's perfect for your needs.

What are the best three-bedroom vacation rentals in or near Seneca?

If you need more room for the youngsters (or a tagalong travel buddy), a three-bedroom vacation property will be just the ticket. Vrbo can help you find the best options in or near Seneca, beginning with these two:

  • Reserve a few nights at "1940's Bungalow Located One Block From Ram Cat Alley - Main St. - In Seneca". Including amenities like a garden and a kitchen, this spacious property will have you feeling right at home.
  • Another enticing three-bedroom rental is "Pirate's Retreat - Beautifully Renovated Lake Home With Dock Minutes From Clemson". Make use of a firepit and a lake view while spending quality time with those you hold dear.