Discover a selection of 68 vacation rentals in De Soto, WI that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including WiFi and outdoor grills and BBQs. Prices start at $163 per night, and houses and cabins are popular options for a stay in De Soto. Either way, you'll find a rental for everyone's needs.
Top rated rentals — De Soto
Destination guide

Book a vacation rental for your De Soto getaway

Learn about the unique charm of De Soto with a stay in a private vacation home. There's no shortage of things to see and do in the area.A vacation rental can help make your stay complete—many rentals come with a full kitchen and laundry facilities.


Sightseeing in and around De Soto

Do you want to discover attractions to visit while you're in the area? Venture out of your vacation home and experience everything that De Soto has to offer. These are some of the major attractions to see, all within 30 miles (48.2 km) of the city center:

  • Vernon Vineyards (12.4 mi / 20 km)
  • Viroqua Country Club (13.9 mi / 22.4 km)
  • Branches Winery (17 mi / 27.4 km)
  • Mount La Crosse Ski Area (19.1 mi / 30.8 km)
  • Snowflake Ski & Golf Club (21 mi / 33.8 km)
Natural features

Exploring the natural landscape of De Soto

Whether you're looking for exciting outdoor activities or just want to spend some time taking in the scenery, De Soto is a great place to get outside. Here are some of the area’s most eye-catching sights, all within 30 miles (48.2 km) of the city center:

  • Clear Creek Park (8.3 mi / 13.4 km)
  • Goose Island County Park (19 mi / 30.6 km)
  • Norskedalen Nature and Heritage Center (20.1 mi / 32.3 km)
  • Yellow River State Forest (21.2 mi / 34.2 km)
How to get there

Transportation options to and around De Soto

Fly into La Crosse, WI (LSE-La Crosse Municipal), the closest airport, located 28.8 mi (46.3 km) from the city center.

How many vacation rentals are available around De Soto, WI?

Our 2021 property listings offer a large selection of 68 vacation rentals around De Soto. From 58 house rentals to 34 cabin rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

Can I rent Houses in De Soto?

Yes, of course. Vrbo has 58 Houses in De Soto. Our other popular types of vacation rentals in De Soto include:

  • Cabins: 34 rentals available
  • Cottages: 33 rentals available
  • Condos/Apartments: 2 rentals available

But you can also enjoy a great stay in one of our other vacation rentals including Bungalows and more.

Can I find a vacation rental with pool in De Soto?

Yes, you can select your preferred vacation rental with pool among our 3 vacation rentals with pool available in De Soto. Please use our search bar to access the selection of vacation rentals available.