Discover a selection of 1,000 vacation rentals in Mission District, San Francisco that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including WiFi and parking. Prices start at $84 per night, and houses and condos are popular options for a stay in Mission District. Either way, you'll find a rental for everyone's needs.
Top rated rentals — Mission District
Destination guide

Multiculturalism in the Mission District

Famously multicultural, the Mission District is one of San Francisco's most eclectic neighborhoods. It's an enclave for Latin American immigrants, which means you'll find traditional taquerias, colorful produce stalls and local bodegas on every corner. Thanks to its free-spirited attitude, the Mission District has become a popular hangout for hipsters. As a result, the neighborhood has also seen an explosion of live-music clubs, trendy third wave coffee shops, tattoo parlors and craft cocktail bars. If you want to experience the city through a local lens, Mission District vacation rentals unlock access to this captivating slice of San Francisco.

Things to do

Gallery hopping in the Mission District

While the Mission District is best known for its street art, galleries like Southern Exposure champion a curated approach. Also known as SoEx, this contemporary non-profit gallery showcases San Francisco's up-and-coming visual artists. For a unique night out, score tickets to a show at the Roxie Theater, San Francisco's original playhouse. More than 100 years old, it screens cult classics, film noirs, vintage horrors, edgy documentaries and more. For a glimpse of the neighborhood's namesake, head to Mission Dolores. Founded in 1776, the enclave is one of San Francisco's oldest buildings.


Street art and murals in the Mission District

Thanks to its vibrant Latino roots, the Mission District is a hub for arts and culture. Clad in colorful murals, Clarion Alley is one of San Francisco's most-photographed streets. Upmarket Valencia Street boasts some of San Francisco's best shopping, with a myriad of trendy boutiques and independent designers to discover. You'll also find a glut of artisan coffee shops, Mexican eateries and vegan cafes. Want to stay local? Mission District vacation rentals put you just steps from Valencia Street. Head down Mission Street and you'll find a treasure trove of sidewalk stalls selling second-hand clothes, handcrafted wares and everything in-between.

Natural features

The Mission District is perfect for picnics

The Mission District is anchored by Dolores Park, the neighborhood's signature green space. It lures locals with grassy lawns, lush palms and sweeping views of the San Francisco skyline. On a sunny day, there's no better place to enjoy a picnic and a bottle of wine. Located in the grounds of Mission Dolores, the Golden Gate Rose Society Garden is one of the city's best-kept secrets. Inside you'll find a wonderland of sumptuous rose gardens. The Native American-themed botanic garden, filled with indigenous plants, is also worth a visit.

What are the top vacation rentals in or near Mission District?

Whether you're seeking a cozy retreat for you and your sweetheart or someplace spacious to fit the family, you'll find some top vacation rentals in and around Mission District. Here are a couple to get you thinking:

  • Around 3 miles from the center of Mission District, it's difficult to beat "Golden Gate Park And Museums 1 Block Away". It has 2 bedrooms and handy features including a toaster and a hair dryer.
  • Another great option is "Luxurious Top - Rated Nopa Home + Garage + Free Cleaning", which is around 2 miles from Mission District. Featuring 1 bedroom, an iron and ironing board and coffee and tea making facilities, it has everything you need to keep you comfortable and content.

For even more great options, use the search bar at the top of the page to find the perfect Mission District vacation rental for you.

What are the top-rated vacation rentals for weekend getaways in or near Mission District?

We all deserve a break from time to time. If you're craving a couple of uninterrupted mornings lounging around with a good book and a steaming coffee, we've got some amazing weekend getaways in and around Mission District. These are some of our favorites:

  • Make yourself at home at "Waterfront Marina - One Of Kind Garden Unit". Located around 3 miles to the north of Mission District, this escape has all you need for a relaxing stay, including a nearby laundromat and a washing machine.
  • "West Portal Studio, Ocean View And Convenient" is another top-rated option. It's around 2 miles to the southwest of Mission District and comes with WiFi, heating and more.

Can I find studio apartments for rent in and around Mission District?

Studio apartments are a hard act to beat when it comes to convenience and location. Take a look at these studio apartments for rent in or near Mission District and experience the local culture and vibe:

  • Make "Luxurious Top - Rated Nopa Home + Garage + Free Cleaning" your temporary home. This sought-after vacation rental features amenities including internet services and winery tours.
  • Alternatively, switch to vacation mode at "West Portal Studio, Ocean View And Convenient", which offers conveniences including a free nearby fitness center and a TV.

With the moolah you save on your studio apartment, you can afford to explore even more of Mission District. Cultural attractions like Victoria Theatre and Alcove Theater will help you get a feel for the character of this destination.

Can I find short term rentals in or near Mission District?

Short-term rentals are easy to find in and around Mission District. Chill out for a few days in a luxury bed & breakfast, a studio apartment or a spacious house. Whatever type of vacation rental you're after, you'll have plenty to choose from with Vrbo. Here are some of our favorite options:

  • Nice and close to the center of Mission District, "Beautiful Renovated Flat Near Golden Gate Park" is an ideal base for a quick getaway. While you're about, be sure to visit top attractions like Pier 39 and Golden Gate Bridge.
  • "Luxury Oasis With Hot Tub And Gorgeous Garden" is another fabulous option. We suggest adding Alcatraz Island and Lombard Street to your must-do list when it's time to sightsee.

What are the best romantic weekend getaways in or near Mission District?

Whether spent in a cabin, an apartment or a lodge, a romantic weekend getaway is one of the best ways to add some zing to your relationship. Whisk your sweetheart off for a couple of relaxing days at one of these sought-after escapes in or near Mission District:

  • Slip away on Friday for a few passion-filled evenings at "Golden Gate Park And Museums 1 Block Away". Located around 3 miles from Mission District, this property comes with lots of nice touches, like a nearby bay and winery tours.
  • "Luxurious Top - Rated Nopa Home + Garage + Free Cleaning" is another retreat that'll woo you. It's about 2 miles from Mission District and has winery tours and beauty services.

What are the best large group vacation rentals in or near Mission District?

Big groups mean enormous fun. They also mean finding someplace that'll effortlessly fit your entire squad. Browse our large group vacation rentals in or around Mission District and get everybody together under the same roof:

  • There's plenty of space to spread out at "Comfortable Vacation Home Near". Around 10 miles south of Mission District, this welcoming property has 5 bedrooms sleeping up to 12 guests. Amenities include a kitchen and a TV.
  • Invite up to 12 of your best friends to "Amazing Large Central Flat" and fill the place with laughter and love. This popular option has 3 bedrooms and is around 2 miles to the north of Mission District. It's packed with features to keep large groups comfortable, such as a kitchen and a fireplace.

What are the best houses for rent with a pool in or near Mission District?

From boisterous games of Marco Polo to refreshing morning dips, a pool promises fun for all ages. Score some brownie points with the fam by renting a house with a swimming space in or near Mission District:

  • First on our list of cool pool escapes is "3br, 5 Guests Amazing Victorian House With Breathtaking Views". Vacationing families will feel at home here, with useful amenities like on-site watersports and a nearby bay also at hand.
  • Alternatively, stay at "Modern, Spacious Tri - Level House With Roof Deck Views" and spend your break poolside. A toaster and a travel crib are other things your gang will love about this rental.

What are the best large family vacation rentals in or near Mission District?

Every family catch-up should be one to remember. Whether you're planning a break with the kids or a long-overdue family reunion, Vrbo's large family vacation rentals in or near Mission District offer a comfy home away from home with enough space for everyone:

  • Sleeping up to 8 guests in 4 bedrooms, "Short Term Or Long Term Furnished Or Unfurnished Available Now" is the perfect place for some family time. This popular getaway is 3 miles to the northwest of Mission District and has creature comforts that include books and a nearby laundromat.
  • Another top choice is "Comfortable Vacation Home Near". This vacation rental is 10 miles south of Mission District and features a dining table, a kitchen and more. With 5 bedrooms accommodating up to 12 people, you won't need to leave anyone off your invitation list.

If you'd love to do some sightseeing, there are loads of family-friendly attractions close by to put on your to-do list. Pier 39, Golden Gate Bridge and Lombard Street are good places to start.

Are there one-bedroom vacation rentals in or near Mission District?

Romantic getaways, work trips or adventures all on your own — a one-bedroom rental property is an ideal solution for a multitude of occasions. One of our options in or near Mission District is sure to be just right:

  • Consider "Luxurious Top - Rated Nopa Home + Garage + Free Cleaning", a great centrally located one-bedroom property. A garden and a kitchen are just two of the amenities here.
  • Also within easy reach of all the delights of Mission District, "West Portal Studio, Ocean View And Convenient" is another popular one-bedroom option. After a big day of seeing the sights, come home and enjoy amenities like a garden and a kitchen.

Can I find two-bedroom vacation rentals in or near Mission District?

At Vrbo, we've got rental places in or near Mission District to suit all styles and budgets. Here are some of our favorite two-bedroom options to get you started:

  • With amenities like a fireplace and a garden, "Private Road - Near Bike Trail And Beaches" has all you need for a pleasant stay. Settle in and then get out and explore the neighborhood.
  • "Original Sf Edwardian Intersects Duboce Triangle" is another lovely two-bedroom retreat. It offers a kitchen, a garden and more.