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Serenity South -- Gardens, River-Views, and Refreshing Space

Riverfront vacation home with kitchen and balcony

Photo gallery for Serenity South -- Gardens, River-Views, and Refreshing Space

Exterior
Entryway into the house.
Interior
Entryway into house.
Living room

Reviews

10 out of 10, Loved by Guests
3 bedrooms1+ bathroomSleeps 51600 sq ft

Popular amenities

  • Kitchen
  • Outdoor Space
  • Parking available
  • Fireplace

Explore the area

View in a map
Cape Girardeau, MO
  • Place, Riverfront Park
    ‪2 min walk‬
  • Place, Riverfront Bridge Park
    ‪5 min walk‬
  • Place, Isle Casino Cape Girardeau
    ‪16 min walk‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪9 min drive‬

Rooms & beds

3 bedrooms (sleeps 5)

Back bedroom

1 Double Bed

Master bedroom

1 King Bed

Middle bedroom

2 Twin Beds

1 bathroom, 1 half bathroom

Main floor bathroom

Toilet

Upstairs Bathroom

Bathtub or shower · Toilet

Spaces

Deck or patio
Porch or lanai
Kitchen
Balcony
Separate dining area
Outdoor play area
Garden

About this property

Serenity South -- Gardens, River-Views, and Refreshing Space

Beautifully renovated duplex with large shared yard in Cape Girardeau Historic District. Cozy living room, large dining room, fully stocked kitchen, 3 second-story bedrooms with balcony at the end of the hall, and 1 1/2 bathes. Perfect for getting away for rejuvenation or exploring downtown. Within walking distance to local downtown restaurants, antique shops, and boutiques. Two blocks from the Mississippi River and many other attractions.
Our prices include all fees. No hidden fees.

Add dates for prices

Amenities

Kitchen
Air conditioning
Outdoor Space
Parking available
Fireplace

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House Rules

Check in after 4:00 PM
Minimum age to rent: 18
Check out before 11:00 AM
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Children

Children allowed: ages 0-17
Excellent fenced back yard.
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Events

Events allowed: family gatherings, birthday parties, weddings
Parties or events must okayed before arrival.
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Pets

No pets allowed
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Smoking

Smoking is not permitted
Back yard is shared with the other side of the duplex. Please respect their use of the common space.

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Parties and events (including family gatherings, birthday parties and weddings) are allowed on site; maximum attendees: 50
Note from host: Parties or events must okayed before arrival.
Host has indicated there is a carbon monoxide detector on the property
Host has indicated there is a smoke detector on the property
Safety features at this property include a deadbolt lock
Property # 1711160

We should mention

A car is not required for transportation to and from this property

About the neighborhood

Cape Girardeau

Located in Cape Girardeau, this vacation home is on a river. EDen Spa & Salon and Hunter Valley Winery are worth checking out if an activity is on the agenda, while those wishing to experience the area's natural beauty can explore Mississippi River and Union County State Fish and Wildlife Area. Traveling with kids? Consider Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. Motor boating and fishing offer great chances to get out on the surrounding water, or you can seek out an adventure with hiking/biking trails and cycling nearby.
View more Vacation Homes in Cape GirardeauOpens in a new window
Map
Cape Girardeau, MO

What's nearby

  • Riverfront Park - 2 min walk - 0.2 km
  • Riverfront Bridge Park - 5 min walk - 0.4 km
  • The Glenn House - 5 min walk - 0.4 km
  • Isle Casino Cape Girardeau - 16 min walk - 1.4 km
  • Southeast Missouri State University - 2 min drive - 1.8 km

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 12 min drive

Restaurants

  • ‪Sand's Pancake House - ‬11 min walk
  • ‪Katy O'Ferrell's Publick House - ‬9 min walk
  • ‪Hotshots Sports Bar & Grill - ‬5 min walk
  • ‪Minglewood Brewery - ‬7 min walk
  • ‪The Library - ‬3 min walk

Frequently asked questions

Is Serenity South -- Gardens, River-Views, and Refreshing Space pet-friendly?

No, pets are not allowed at this property.

How much does it cost to stay at Serenity South -- Gardens, River-Views, and Refreshing Space?

As of Dec 29, 2025, prices found for a 1-night stay for 2 adults at Serenity South -- Gardens, River-Views, and Refreshing Space on Jan 2, 2026 start from $215.95, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

How much is parking?

Onsite parking is available at the property.

What time is check-in at Serenity South -- Gardens, River-Views, and Refreshing Space?

Check-in begins at 4:00 PM.

What time is check-out at Serenity South -- Gardens, River-Views, and Refreshing Space?

Check-out is at 11:00 AM.

Where is Serenity South -- Gardens, River-Views, and Refreshing Space located?

This family-friendly Cape Girardeau vacation home is located on a river, just steps from eDen Spa & Salon and Mississippi River. Shawnee National Forest and Riverfront Park are just steps away.

Reviews

10

Exceptional

Reviews are presented in chronological order, subject to a moderation process, and verified unless otherwise labeled.
Learn moreOpens in a new window
Rating 10 - Excellent. 144 out of 149 reviews
Rating 8 - Good. 5 out of 149 reviews
Rating 6 - Okay. 0 out of 149 reviews
Rating 4 - Poor. 0 out of 149 reviews
Rating 2 - Terrible. 0 out of 149 reviews

10/10

Cleanliness

10/10

Property conditions & facilities

10/10

Check-in

10/10

Communication

10/10

Location

10/10

Listing accuracy

Reviews

10/10 Excellent

Tracy H.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Such a great place and location
Stayed 2 nights in Jul 2025

10/10 Excellent

Sandy M.

Liked: Cleanliness, check-in, communication, location, listing accuracy
We were visiting our daughter who attends SEMO, so the location was perfect.
Stayed 3 nights in Sep 2025

10/10 Excellent

Shelley L.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Good stay.
Stayed 1 night in Sep 2025

10/10 Excellent

Isaac S.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Home was very tidy, kitchen was spacious, and bedrooms comfortable.
Stayed 2 nights in Oct 2025

10/10 Excellent

Michael R.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Nice property near downtown in the river. This was the perfect location for our 50th high school reunion.
Stayed 2 nights in Oct 2025

10/10 Excellent

Jodie F.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Enjoyed everything! Great location!
Stayed 4 nights in Jul 2025

10/10 Excellent

Vicki R.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Beautiful house. Great stay. Would definitely stay again!
Stayed 1 night in Jun 2025

8/10 Good

Michael W.

Liked: Cleanliness, check-in, communication
All was good except for the strange fact of 3 rentals at the same place and the older couple in the backyard was a little off putting.
Stayed 1 night in Oct 2025

10/10 Excellent

Deborah K.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Charming house within walking distance to downtown restaurants and bars. Host is wonderful! Great communication.
Stayed 1 night in Sep 2025

10/10 Excellent

Donna D.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Lovely as always

Moving our daughter in to the dorm at SEMO for yr 2. Been coming to this location since our trip here during her senior year of HS when she visited SEMO to audition for the musical theatre program. It is a great place to stay when you have more than 2 people.
Stayed 1 night in Aug 2025

10/10 Excellent

John

Liked: Cleanliness, property conditions & facilities, communication
Great place.
Stayed 1 night in Dec 2023

10/10 Excellent

Penny F.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Beautiful getaway!

The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area.
Stayed 2 nights in Mar 2025

10/10 Excellent

Sam E.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Downtown home with great character

My son and two brothers stayed a night in this lovely home. I travel to Cape frequently to visit my son and will definitely stay here again.
Stayed 1 night in Apr 2025

10/10 Excellent

Tim B.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Great stay

Beautiful home, great location, well equipped kitchen.
Stayed 5 nights in Oct 2022

10/10 Excellent

Linden S.

Liked: Cleanliness, check-in, communication, location, listing accuracy

A Beautiful Retreat for Three Generations

Three generations found rest,beauty,& joy at Serenity South. Thoughtful touches,beautiful gardens and Cape charm made this more than a stay-it became a treasured memory. We were so appreciative of the details, the fresh flowers, homemade cookies, the coffeemaker upstairs and the books and games. The beds were all comfortable. We enjoyed this historical home and our stay.
Stayed 2 nights in May 2025

10/10 Excellent

Bryan P.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Comfortable & Clean

Great Location short walking distance to the Downtown Area with lots do do, Restaurants, Water Park, Shopping. This is the 2nd time I have stayed and it is a true delight. Very spacious and comfortable. Easy to communicate with the Owner/Manager. I will be staying there again in the future. I recommend it with 5 Stars!
Stayed 1 night in Jun 2025

10/10 Excellent

Michelle K.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Perfect home for college visit

When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay.
Stayed 1 night in Feb 2025

10/10 Excellent

Bradley T.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Peaceful place

Very nice and beautiful place super nice people
Stayed 2 nights in Jun 2024

10/10 Excellent

STEPHANIE L.

Liked: Cleanliness, check-in, communication, location, listing accuracy

In town for one day

Its was different, but over all it was on point.I will rebook this summer
Stayed 1 night in May 2025

10/10 Excellent

Nichole C.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Serenity south was welcoming comfortable and very clean. Impeccably maintained historic home. Comfortable beds, great water pressure and shower head, easy to maintain consistent temperature. Good vibes throughout. Not haunted. Beautiful outdoor space but it was too hot to use it much while we were there. Recommend stopping by the olive oil store William and Water across the street.
Stayed 3 nights in Jul 2025

10/10 Excellent

Rhonda S.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Smith Women’s Weekend

We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year!
Stayed 2 nights in Feb 2025

10/10 Excellent

Terry M.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Great family getaway

Everything was perfect. From check in to check out. Great neighborhood and location.
Stayed 1 night in Apr 2024

10/10 Excellent

Danita D.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Historic charm

We loved staying at this house for SEMO family weekend! It was super clean and had everything we needed and more 😊 we will definitely try to stay here again!
Stayed 1 night in Sep 2023

10/10 Excellent

Candice L.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Family Graduation

The place was perfect for our stay and was close to the farmers market and downtown shops. Highly recommend for location!
Stayed 1 night in May 2024

10/10 Excellent

Nolan R., Tacoma, WA

Liked: Cleanliness, check-in, communication, location, listing accuracy

Wonderful all around!

Great location and property! Stayed with several friends and it’s offered lots of space for everyone. Very close to many downtown attractions! Would definitely stay again!
Stayed 2 nights in Oct 2019

About the host

Hosted by Jo Pincosy

Host profile image

Languages:

English
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