Photo by Hecktic Travels

Mytilene vacation rentals

We found 75 vacation rentals — enter your dates for availability

Discover a selection of 15 homes, 22 apartments, and other vacation rentals in Mytilene that are perfect for your trip. Vacation rentals provide the best amenities for your family, friends, or furry companion, like WiFi and a washer and dryer. What you'll find is a rental to meet everyone's needs, including options that are accessible or non-smoking.

Find spaces that suit your style

  • Peace of mind

    Our Book with Confidence guarantee gives you 24/7 support

  • All the privacy of home

    Enjoy full kitchens, laundry, pools, yards and more

  • More for less

    More space, more privacy, more amenities — more value

  • A place for everyone

    We stand for diversity, inclusion and families everywhere.
    Learn more

Find out more about Mytilene

The waterfront setting of Mytilene is ready to explore

Take a vacation to Mytilene and enjoy the area's museums, monuments and churches. This city's island views, seaside and architecture draw many visitors. If you need more space to accommodate a family vacation or friends trip, rental homes often come with separate dining areas and spacious living rooms.

Exploring the natural features in Mytilene

Whether you're an adventurous traveler or just want to appreciate the scenery, Mytilene is a great place to spend some time outside. These are a few of the area's most enchanting features, all within 30 miles (48.2 km) of the city center:

  • Thermi Beach (6.3 mi / 10.1 km)
  • Altinova Beach (12.2 mi / 19.7 km)
  • Badavut Beach (12.8 mi / 20.5 km)
  • Plomari Beach (12.8 mi / 20.6 km)
  • Sarimsakli Beach (13 mi / 21 km)
  • Fame Beach (13.9 mi / 22.4 km)

Transportation options to and around Mytilene

Fly into Mytilene (MJT-Mytilene Intl.), the closest airport, located 4 mi (6.4 km) from the city center.

Frequently asked questions

What is the best area to stay in Mytilene, North Aegean Islands, Greece when booking a vacation rental?
When considering a vacation rental in Mytilene, a popular area to stay is near the waterfront, where you can enjoy stunning views of the Aegean Sea. This area is particularly vibrant, with a variety of properties that cater to different preferences, from cozy apartments to charming villas. You'll find yourself close to the bustling harbor, which is a hub of activity and offers a delightful selection of cafes and restaurants where you can savor local cuisine.

Another fantastic neighborhood is the historic center, where you can immerse yourself in the rich culture of the city. Here, you can explore impressive landmarks such as the Archaeological Museum, showcasing artifacts from the region's ancient history, and the iconic Castle of Mytilene, which provides a glimpse into the island's storied past. The blend of history and modern life creates a special environment that makes this area particularly appealing for visitors.

In terms of accommodation options, there are numerous properties available in both areas, making it easy to find a rental that suits your needs.
How much does it cost to rent a vacation home in Mytilene?
Prices for vacation rentals in Mytilene vary based on factors like travel dates, length of stay, accommodation type, and location. Simply enter your trip details to explore a wide range of options—whether you're traveling solo, as a couple, with family, or in a group. Vrbo offers something for every taste and budget, from affordable rentals in Mytilene to more spacious homes. To get the best value, book early and take advantage of Vrbo's free rewards program.
Are there any discounts for Mytilene vacation house rentals?
You can find great discounts on house rentals in Mytilene on Vrbo, including special rates on new listings and savings for weekly or monthly stays with top amenities such as a pool or parking. There are several discounts for Last minute bookings, and Early bird bookings too. The best part is, there's no need for a discount code—just enter your travel dates and apply the discount filters to view the top rates.
Can I find long-stay vacation rentals in Mytilene?
A long-stay vacation rental in Mytilene is the best way to experience local living. Plus, you can make the most of long-stay discounts. For month-long stays, save an average of 19%, and for week-long bookings you can save an average of 10%.* Long-stay discounts are applied automatically when you enter your vacation dates into the search tool, or you can use the "Weekly stay" and "Monthly stay" filters in your search.

*Based on analysis of Vrbo booking and occupancy data for 2024 stays.
Are there any Mytilene vacation rentals with parking?
Vrbo offers a wide selection of vacation rentals in Mytilene with parking available—perfect for families or travelers who value the convenience of having a car during their stay. To easily find these properties, simply enter your travel details on Vrbo and use the "Parking available" filter under the amenities section. This makes it quick and easy to browse listings that suit your needs, whether you're planning a short city break or a longer stay.
When is the best time to visit Mytilene for a vacation rental?
The best time to visit Mytilene for a vacation rental is September, when the summer crowds begin to dissipate, yet the weather remains pleasantly warm. This month marks the tail end of the peak season, which runs from August to October, making it an ideal time for travelers seeking a more relaxed experience while still enjoying the vibrant setting of the island.

In September, temperatures typically range from the mid-60s to the low 80s Fahrenheit, offering comfortable conditions for outdoor activities such as exploring ancient ruins, lounging on beautiful beaches, or savoring local cuisine at charming tavernas. The warm sea temperatures also make it great for swimming and water sports, ensuring you can take full advantage of Mytilene's stunning coastline.

For those who are budget-conscious, December presents a unique opportunity to visit Mytilene at a lower cost. While this is considered the low season, it offers a chance to experience the local culture without the hustle and bustle of peak tourist traffic. You can enjoy quiet walks through the historic town, visit local markets, and appreciate the island's beauty in a more tranquil setting.
How early should I book a Mytilene vacation rental?
Book your Mytilene vacation rental at least two months before you travel for the best selection of properties.* Plus, you'll typically find that the earlier you book your vacation rental, the better the price.

*Based on analysis of Vrbo booking and occupancy data for 2024 stays.
What are the top attractions in Mytilene, North Aegean Islands, Greece?
In Mytilene, travelers can explore a rich tapestry of history and culture. The Castle of Mytilene, a prominent landmark, offers breathtaking views of the city and the harbor, showcasing its medieval architecture. Nearby, the Archaeological Museum of Mytilene houses an impressive collection of artifacts, including ancient sculptures and pottery that reflect the island's storied past.

The charming streets of the town feature traditional Greek architecture, with quaint shops and cafes inviting visitors to sample local delicacies. The waterfront promenade is great for leisurely strolls, where you can enjoy the scenic views of the Aegean Sea.

For those interested in nature, the nearby Petrified Forest of Lesvos is a unique attraction, showcasing fossilized trees that date back millions of years.
Can I change or cancel my Mytilene home rental booking on Vrbo?
To find Mytilene vacation rentals with free cancellation, just use Vrbo's handy "Free cancellation" search filter. We get that plans can change, so it's easy to filter properties that give you flexibility. If you need to make changes to an existing booking, drop your host a message. Go to "My Trips" in your account, click "Change or Cancel" and then "Message Host". Vrbo rentals give you the privacy of having the entire place to yourself, and for extra flexibility, some travelers can choose to pay over time with Affirm. Whether you're adjusting your plans or looking for flexible payment options, Vrbo makes it easy to book with confidence.
Why should I join Vrbo as a host?
Joining Vrbo as a host opens the door to a global community of travelers seeking unique stays, giving you the opportunity to earn income from your property on your terms. With user-friendly tools, dedicated support, and exposure on major travel sites, Vrbo makes it easy to list, manage, and succeed. Whether it's a cozy cabin or a beach condo, you can turn your space into a standout destination, become a host and let Vrbo handle the heavy lifting to help you thrive.

Earn a Premier Host badge by providing quick, reliable communication and consistently delivering outstanding guest experiences.
Are all fees included in the Mytilene vacation rental prices shown on Vrbo?
Vrbo provides upfront pricing from the moment you start your search. There are no hidden fees added during the check-out process. This allows you to compare properties with ease and plan your trip with confidence.
What is VrboCare™ and how does it work?
Vrbo's mission is to help guests relax, reconnect, and enjoy precious time together. With VrboCare™, you can have peace of mind knowing you're protected and that if something goes wrong, we will do our best to make it right as applicable.

If a significant issue arises that your host can't resolve, we'll help you address it, find a similar property, or get your reservation refunded if applicable. That's our promise. If a home is significantly different than listed, we'll get you into a new space that meets your needs and makes it right, or if a host cancels before your stay, you have a dedicated support team to get you into a similar home as applicable.
What can I expect from Vrbo customer service and VrboCare™ support?
Your peace of mind is our priority. Whether you're planning your trip or have already finished your stay, VrboCare™ is here to support you every step of the way. For urgent situations like last-minute cancellations, booking issues, or potential fraud, Vrbo customer service is available 24/7 to help resolve problems quickly and effectively.

Vrbo also offers support via live chat through our Help Center, where you can find helpful resources on bookings, payments, property management, and safety, making it easy to get instant answers to many common questions.
Can I plan a group trip on Vrbo?
Vrbo's Trip Planner makes organizing group trips easy and stress-free. Whether you're planning with friends or coordinating a large group, you can collaborate in one place, save and share properties, vote on favorites, and build the perfect itinerary together.

Frequently asked questions

Are there vacation rentals in Mytilene?
Yes, we give you a choice of vacation rentals close to the most popular attractions in Mytilene, or you can select a more remote option if you want a relaxing place to stay. Nature enthusiasts will enjoy the seaside in Mytilene. Make sure you have time to check out the museums and monuments during your trip.
How many vacation rentals will I find in Mytilene?
Choose from 15 Expedia vacation rentals in Mytilene for a memorable vacation.
What's there to see and do in Mytilene?
Enjoy the outdoors at Thermi Beach and Thermes Gera Hot Springs, or simply take in cultural attractions like Olive-press Museum of Archipelagos Society and Museum of the Memorial of the Refugees of 1922. While here, Port of Mytilene and Mytilini Castle are other places worth a visit.
What's a vacation rental in Mytilene like?
A vacation rental is a private property you can stay in for a couple of days or more in Mytilene. Vacation rentals provide amenities such as kitchens and laundry facilities so you'll have a home away from home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of seclusion away from shared hotel elevators and busy lobbies while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental an attractive choice for family trips.

More Vacation Ideas