Photo by Michele Butts

La Mesa villas

We found 47 villas — enter your dates for availability

  • Peace of mind

    Our Book with Confidence guarantee gives you 24/7 support
  • More quality time

    From booking to staying, the whole process is simple and enjoyable
  • All the privacy of home

    Enjoy full kitchens, laundry, pools, gardens and more
  • More for less

    More space, more privacy, more amenities — more value

Frequently asked questions

Are there any holiday villa rentals in La Mesa?
Stay in one of our 47 villa rentals in La Mesa and you'll have the ideal base for your next family or group travel experience. Windsor Hills, Rolando Village and Grossmont are some of the city's most popular areas to stay.
How much does it cost to stay in a villa rental in La Mesa?
Exactly where you stay, what time of year you travel and the length of your escape will influence how much you pay for a villa rental in La Mesa. Enter your travel details on Vrbo to compare your options and then lock in the best one for you.
When is the best time to rent a villa in La Mesa?
Consider escaping to La Mesa in May, when the average temperature ranges between 13 ºC (55 ºF) and 22 ºC (72 ºF). This is the most popular month for Vrbo guests to get a villa rental in this destination, which is located in East County.
Where can I rent a La Mesa villa with great views?
When searching for your villa rental in La Mesa, use the "Location" filter. This will help you narrow down the sorts of areas you'd like to stay in, whether that's removed from the hustle and bustle or somewhere close to the action.
Can I book a luxury villa in La Mesa?
Book a stylish villa rental in La Mesa and enjoy the VIP holiday experience. These stays often include high-quality furnishings and modern technology features like built-in surround sound systems. Look for villas with a swimming pool and hot tub, or find one with a private courtyard perfect for sunbathing. With plenty of room to spread out, they're perfect for breaks with the whole family, friends or corporate retreats.
What are the top things to do in La Mesa?
Spend your days sightseeing La Mesa's prominent attractions like San Diego Zoo and your evenings relaxing in the comforts of your inviting villa rental. If you're holidaying with the family, Balboa Park and Petco Park are a couple of other places you can explore as a group.
Why should I book my villa holiday with Vrbo?
Whether you're dreaming of a spacious villa rental in the countryside, by the water or elsewhere, Vrbo has accommodation in gorgeous locations. Just use our filter tool to browse for a stay that suits your needs and preferences. Whatever you choose, one thing is constant — you'll always have exclusive use of your villa. Toss in our Book with Confidence Guarantee and flexible cancellation policies and you've got a trip where peace of mind and relaxation go hand in hand.