St. Charles County, US Vacation Rentals: condo and apartment rentals & more

Discover a selection of 273 vacation rentals in St. Charles County, US that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, Vrbo vacation homes have the best amenities for hanging out with the people that matter most, including swimming pools and private pools. Prices start at $98 per night, and condos and houses are popular options for a stay in St. Charles County. Either way, you'll find a rental for everyone's needs.

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Find the best place to stay — St. Charles County

Search 273 vacation rentals

Stayed Jun 2021

Quaint, Clean, and Spacious

Our stay could not have been any better! The Guest House had plenty of room for our group of 6 long-time girlfriends! Each reported a great night of rest in a big comfortable bed! We loved many things about this prooerty! •Steps away from St. Char...

Stayed Jun 2021

St Charles Old Town Guest House

May and Audrey, the Property Owners, were wonderful at communicating with us before and during our stay! The snacks they provided were yummy too, a nice mix of healthy and snacky! The property was one block from the downtown area, which is great for ...

Stayed May 2021

Just right

We enjoyed 2 days of being tourists in the St Louis area. It was nice to be close enough to attractions but far enough away from the crowds and traffic. The downtown area just a few blocks from the duplex held inviting old-town charm. The house was s...

Stayed May 2021

Wonderful layout

Enjoyed the layout with our friends. The upstairs has a large bedroom and it’s own bathroom. The main floor is open kitchen, dining and living room. The floor below is a beautiful master bedroom with a large bathroom. It was nice to have the living s...

Stayed May 2021

Adorable, idyllic getaway

Gorgeous little house in the middle of Augusta. Great communication. Super comfortable bed (that alone will bring us back here again someday...) Easy walks and short scenic drives to bunches of wineries. The mini fridge is on the small side, so if yo...

Stayed May 2021

Clean and cozy

This house was perfect for a girls weekend. The couches are comfortable for hanging out and the beds are nice and large. There’s plenty of space for settling in and the kitchen is impressively stocked. The host for this property is great about commun...

Stayed May 2021

Girl's Weekend

Five friends traveled to St. Charles for a girls weekend. This location was perfect! We did have one question when we arrived, the owners were very quick to reply and answer our question. I highly recommend this home and look forward to staying again...

Stayed May 2021

Great stay!

We really liked this property overall, especially the room that had many windows to look at the River. It was a quiet place to stay and get away from people. We enjoyed watching the birds with the provided binoculars. It was nice that there were many...

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How many vacation rentals are available around St. Charles County, US?

Our 2021 property listings offer a large selection of 273 vacation rentals around St. Charles County. From 70 condo and apartment rentals to 194 house rentals, find a unique house rental for you to enjoy a memorable holiday or a weekend with your family and friends.

What are the most popular destinations to visit in St. Charles County?

There are many lovely places to stay for a holiday trip or just for a weekend in St. Charles County. From Vrbo travelers, the top most popular destinations to visit are:

St. Charles: 892 vacation rentals
O'Fallon: 65 vacation rentals
Augusta: 132 vacation rentals
St. Peters: 86 vacation rentals
Defiance: 137 vacation rentals

And Vrbo offers you the chance to discover many other popular destinations in St. Charles County! Please use our search bar to access the selection of vacation rentals available in other popular destinations.

What are the main cities to discover in St. Charles County?

Whether you're traveling with family or friends, here are the cities with the largest selection of vacation rentals for a holiday trip or just for a weekend in St. Charles County:

St. Charles: 892 rentals
O'Fallon: 65 rentals
Augusta: 132 rentals
St. Peters: 86 rentals
Defiance: 137 rentals

For other cities, please use our search bar to access the selection of vacation rentals available.

Near which points of interest can I spend my holidays in St. Charles County?

Vrbo offers a large selection of rentals near lovely places in St. Charles County. From Vrbo travelers, the top most popular points of interest to stay for a holiday trip or just for a weekend are:

Katy Trail: 650 rentals
Bear Creek Golf Club: 162 rentals
Historic Daniel Boone Home and Heritage Center: 191 rentals
Montelle Winery: 200 rentals
Yellow Farmhouse Winery: 238 rentals

But there are many other points of interest around St. Charles County listed on Vrbo where you can find your place to stay. Just write your wanted destination in our search bar and have a look at our selection.