East End vacation rentals

We found 906 vacation rentals — enter your dates for availability
Select from 13 houses, 120 condos, and other vacation rentals to find the perfect place for your stay in East End. Vacation rentals offer the best amenities for your stay with friends, family, or just your pet, like parking and a TV. You'll be able to choose a rental that has what everyone needs, including places that are non-smoking or accessible.

Find the best place to stay - East End

Aerial Shot of Crystal Clear Pool
Premier Host
9.8
Exceptional
208 reviews
Amazing Direct Ocean Gulf Front Beach Views Condo, pool and hot tub are open!
Stunning coastal decor
Premier Host
9.6
Exceptional
59 reviews
Sanibel-Style on the East End! Walk to restaurants and the lighthouse. NEW!
Living area
8.8
Excellent
53 reviews
Stunning Luxury villa Sandpiper across the street from the beach!
Dining Area
Premier Host
9.8
Exceptional
8 reviews
Remodeled Island Getaway | Sanibel Arms West – 2BR/2BA Near Beach
Living area
Premier Host
9.6
Exceptional
21 reviews
1BR ocean view condo on Sanibel Island Steps from the beach - Sandalfoot 3B3
Property grounds
Premier Host
9.2
Wonderful
57 reviews
The Lovebird-sleeps 3! Great value on Sanibel-walk to dining, shops and Historic East End Lighthouse

  • Peace of mind

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  • All the privacy of home

    Enjoy full kitchens, laundry, pools, yards and more

  • More for less

    More space, more privacy, more amenities — more value

  • A place for everyone

    We stand for diversity, inclusion and families everywhere.
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Frequently asked questions

Can I find a vacation rental in East End?
Yes, there are vacation rentals in East End close to Sanibel Moorings Botanical Gardens, or you can choose a secluded option if you're looking for extra privacy while you relax.
How many vacation rentals are there in East End?
Choose from 13 Expedia vacation rentals in East End for a memorable vacation.
What's there to see and do in East End?
Sanibel Island Northern Beach and Sanibel Island Southern Beach are a couple of lovely local spots to get outside and enjoy nature. Other places in town to visit include Sanibel Island Lighthouse and Periwinkle Way.
What's a vacation rental in East End like?
A vacation rental is a private property where you can stay for several days or longer in East End. Vacation rentals offer amenities like laundry facilities and kitchens so you'll be comfy for your stay. If you're concerned about cleanliness, a vacation rental can provide a sense of seclusion away from public hotel elevators and busy front desks while still allowing you to travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for a family getaway.