Point Loma is easy to get around and you can pretty much get around however you like! If you are driving, you have direct access to the 5 and 8 freeways! If you prefer streets, then just hop on Nimitz Boulevard for easy access to Downtown as well as the beaches of Mission and Pacific.
The 35 bus is the main bus that runs in Ocean Beach, which has a direct route to the Old Town Transit Center, where you can catch trolleys, buses, or trains to virtually any part of San Diego.