Photo by Jessica King

De Soto vacation rentals

We found 16 vacation rentals — enter your dates for availability

Scroll through and select from vacation rentals in De Soto to find one that's perfect for your trip. Vacation homes provide the amenities you need and want for your stay with friends, family, or just your pet, such as parking and a hot tub. At the end of the day, you'll be able to choose a rental to meet everyone's needs, including a place that's non-smoking or offers accessibility.

Find spaces that suit your style

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  • All the privacy of home

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Find out more about De Soto

Find out more about De Soto

Choose a vacation rental for your De Soto getaway

Learn about the unique charm of De Soto with a stay in a private vacation home. One of the city's many top draws is its restaurants. With a vacation rental, you get a home away from home. Many rentals offer full kitchens and outdoor grills for some home cooking.

Activities and attractions in and around De Soto

Are you hoping to find things to do while you're in the area? Venture out of your cozy vacation rental and experience everything that makes De Soto a one-of-a-kind vacation spot. Here are some of the most popular attractions to put on your list, all within 30 miles (48.2 km) of the city center:

  • Villa Antonio Winery (10.6 mi / 17 km)
  • Persimmon Ridge Winery (14.8 mi / 23.8 km)
  • Bonne Terre Mine (14.9 mi / 24 km)
  • Crown Pointe Golf Club (23.3 mi / 37.5 km)
  • LaChance Winery (18.8 mi / 30.2 km)
  • Fore Honor Golf Course (16.6 mi / 26.7 km)

Exploring the natural landscape of De Soto

Whether you're looking for exciting outdoor activities or just want to take in the scenery, you'll be sure to find the perfect setting for your vacation in De Soto. These are a few of the area's noteworthy features, all within 30 miles (48.2 km) of the city center:

  • Sunrise Lake Beach (6.4 mi / 10.3 km)
  • Indian Foot Lake (11.8 mi / 18.9 km)
  • Bonne Terre Mine (14.9 mi / 24 km)
  • Mastodon State Historic Site (19 mi / 30.6 km)
  • Big River (24.5 mi / 39.4 km)
  • Victoria Glaces Conservation Area Trailhead (4.4 mi / 7.1 km)

Transportation to and around De Soto

Fly into St. Louis, MO (SUS-Spirit of St. Louis), the closest airport, located 36.5 mi (58.8 km) from the city center. If you're unable to find a flight that fits your schedule, you could book a flight to St. Louis Lambert Intl. Airport (STL), which is 42.9 mi (69 km) away.

Frequently asked questions

What is the best area to stay in De Soto when booking a vacation rental?
When considering a vacation rental in De Soto, Missouri, the area surrounding the historic downtown offers a charming and convenient base. This neighbourhood is characterised by its quaint streets, local shops, and a friendly atmosphere, making it a delightful spot for visitors. One of the top attractions nearby is the De Soto City Park, which provides ample opportunities for outdoor activities such as walking, picnicking, and enjoying the natural beauty of the surroundings. Additionally, the De Soto Heritage Museum is a great place to delve into the local history and culture, showcasing the rich heritage of the area.
How much does it cost to rent a vacation home in De Soto?
Prices for vacation rentals in De Soto vary based on factors like travel dates, length of stay, accommodation type, and location. Simply enter your trip details to explore a wide range of options—whether you're travelling solo, as a couple, with family, or in a group. Vrbo offers something for every taste and budget, from affordable rentals in De Soto to more spacious homes.
Are there any discounts for De Soto vacation house rentals?
You can find great discounts on house rentals in De Soto on Vrbo, including special rates on new listings and savings for weekly or monthly stays with top amenities such as a pool or parking. There are several discounts for Last minute bookings, and Early bird bookings too. The best part is, there's no need for a discount code—just enter your travel dates and apply the discount filters to view the top rates.
What is the most popular type of vacation rental accomodation in De Soto?
In De Soto, a variety of vacation rental options are available, with cabins, cottages, condos, vacation houses, and villas being the most common types, each found in several locations throughout the area. Many of these rentals feature essential amenities such as fully equipped kitchens, spacious living areas, and outdoor spaces like decks or patios that allow guests to enjoy the natural surroundings. The cabins and cottages, in particular, provide a rustic charm, ideal for those seeking a peaceful retreat.
Are there any family house rentals in De Soto?
In De Soto, Missouri, there are several family-friendly house rentals available, superb for visitors looking to enjoy a comfortable stay. The area offers a variety of homes that cater to families, featuring spacious living rooms, fully equipped kitchens for preparing meals, and outdoor areas for children to play. Many properties also include amenities such as air conditioning, Wi-Fi, and laundry facilities, ensuring a convenient and enjoyable experience.
Can I rent a vacation home with a pool or hot tub in De Soto?
In De Soto, Missouri, there are several vacation homes available for rent that feature pools and hot tubs, offering a delightful retreat for travellers. The town and its surrounding areas provide a serene atmosphere, great for relaxation. Many of these properties are equipped with essential amenities such as fully stocked kitchens for self-catering, spacious living areas, and outdoor spaces ideal for lounging by the pool.
Can I find long-stay vacation rentals in De Soto?
A long-stay vacation rental in De Soto is the best way to experience local living. Plus, you can make the most of long-stay discounts. Long-stay discounts are applied automatically when you enter your travel dates into the search tool, or you can use the "Weekly stay" and "Monthly stay" filters in your search.
Are there pet-friendly house rentals in De Soto?
In De Soto, Missouri, there are several pet-friendly house rentals available for travellers seeking a comfortable stay. Many of these properties come equipped with amenities such as fully furnished kitchens, spacious living areas, and outdoor spaces where pets can enjoy the fresh air. Travellers can expect an inviting space, making it easy to relax with furry companions.
Are there any remote work vacation rentals in De Soto?
In De Soto, Missouri, there are several remote work vacation rentals available that cater to those looking to combine work and leisure. These properties typically offer amenities such as dedicated workspace, Wi-Fi, and comfortable desks, making it easy for travellers to stay productive while enjoying their getaway. Many rentals also feature spacious living areas and fully equipped kitchens, allowing for a home-like experience during your stay. The peaceful surroundings of De Soto provide a conducive environment for focusing on work, while also being near local attractions and outdoor recreational opportunities. To help narrow your search, insert your dates and apply the "WiFi" filter on Vrbo.
Are there any De Soto vacation rentals with parking?
Vrbo offers a wide selection of vacation rentals in De Soto with parking available—perfect for families or travellers who value the convenience of having a car during their stay. To easily find these properties, simply enter your travel details on Vrbo and use the "Parking available" filter under the amenities section. This makes it quick and easy to browse listings that suit your needs, whether you're planning a short city break or a longer stay.
When is the best time to visit De Soto for a vacation rental?
August is the most popular month to visit De Soto, Missouri, drawing families and adventure seekers keen on enjoying the vibrant summer atmosphere. The peak season spans from June to August, making this time ideal for outdoor activities, including hiking, fishing, and exploring the scenic parks in the area. The warm temperatures, typically reaching the mid to high 20s Celsius, create a superb setting for enjoying the great outdoors.

For those who appreciate a lively environment, August offers a lot of local events and activities, allowing visitors to engage with the community while soaking up the sun. Popular attractions such as the nearby Huzzah Conservation Area and Meramec River provide excellent opportunities for water sports and nature walks.

If you're looking for a more budget-friendly option, consider visiting in December. While this month is quieter, it presents a unique charm, with the chance to experience the festive vacation season in a tranquil setting. The town's decorations and events can offer a delightful atmosphere for those who prefer a slower pace.
How early should I book a De Soto vacation rental?
Book your De Soto vacation rental at least two months before you travel for the best selection of properties.* Plus, you'll typically find that the earlier you book your vacation rental, the better the price.

*Based on analysis of Vrbo booking and occupancy data for 2024 stays.
Can I change or cancel my De Soto home rental booking on Vrbo?
To find De Soto vacation rentals with free cancellation, just use Vrbo's handy "Free cancellation" search filter. We get that plans can change, so it's easy to filter properties that give you flexibility. If you need to make changes to an existing booking, drop your host a message. Go to "My Trips" in your account, click "Change or Cancel" and then "Message Host". Vrbo makes it easy to book with confidence.
Why should I join Vrbo as a host?
Joining Vrbo as a host opens the door to a global community of travellers seeking unique stays, giving you the opportunity to earn income from your property on your terms. With user-friendly tools, dedicated support, and exposure on major travel sites, Vrbo makes it easy to list, manage, and succeed. Whether it's a cosy flat or a countryside retreat, you can turn your space into a standout destination—become a host and let Vrbo handle the heavy lifting to help you thrive.
Are all fees included in the De Soto vacation rental prices shown on Vrbo?
Vrbo provides upfront pricing from the moment you start your search. There are no hidden fees added during the check-out process. This allows you to compare properties with ease and plan your trip with confidence.

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