Photo by Isa

Santa Ana holiday lettings

We found 220 holiday rentals — enter your dates for availability

Discover a selection of 75 apartments and other holiday rentals in Santa Ana that are perfect for your trip. Holiday rentals offer the amenities that you expect for you and your friends, family or even pets, such as a hot tub and a washer and dryer. You'll be sure to find a property to rent for everyone's needs, including options that are accessible or non-smoking.

Find spaces that suit your style

  • Peace of mind

    Our Book with Confidence Guarantee gives you 24/7 support

  • More quality time

    From booking to staying, the whole process is simple and enjoyable

  • All the privacy of home

    Enjoy full kitchens, pools, gardens and more

  • More for less

    More space, more privacy, more amenities — more value

Frequently asked questions

What is the most popular type of holiday rental in Santa Ana?
In Santa Ana, apartments are the most prevalent type of holiday rental, with around 42 available in the area. These apartments are typically found in convenient locations, offering easy access to local amenities and attractions. Most rooms come with fully equipped kitchens, comfortable living areas, and often have balconies that provide pleasant views of the surroundings.
Are there any beach house rentals in Santa Ana?
In Santa Ana, Panamá Province, there are about 18 beach house rentals available, predominantly located near the coastline and in tranquil neighbourhoods. These properties typically offer a range of amenities, including spacious living areas, fully equipped kitchens, and private outdoor spaces where guests can relax and enjoy the tropical surroundings. Many beach houses are situated close to local attractions, allowing easy access to the vibrant culture and natural beauty of the area.
How much does it cost to rent a holiday home in Santa Ana?
Prices for holiday rentals in Santa Ana vary based on factors like travel dates, length of stay, accommodation type, and location. Simply enter your trip details to explore a wide range of options—whether you're traveling solo, as a couple, with family, or in a group. Vrbo offers something for every taste and budget, from affordable rentals in Santa Ana to more spacious homes. To get the best value, book early and take advantage of Vrbo's free rewards program.
Are there any discounts for Santa Ana holiday house rentals?
You can find great discounts on house rentals in Santa Ana on Vrbo, including special rates on new listings and savings for weekly or monthly stays with top amenities such as a pool or parking. There are several discounts for Last minute bookings, and Early bird bookings too. The best part is, there's no need for a discount code—just enter your travel dates and apply the discount filters to view the top rates.
Are there any Santa Ana holiday rentals with parking?
Vrbo offers a wide selection of holiday rentals in Santa Ana with parking available—perfect for families or travellers who value the convenience of having a car during their stay. To easily find these properties, simply enter your travel details on Vrbo and use the "Parking available" filter under the amenities section. This makes it quick and easy to browse listings that suit your needs, whether you're planning a short city break or a longer stay.
Can I find long-stay holiday rentals in Santa Ana?
A long-stay holiday rental in Santa Ana is the best way to experience local living. Plus, you can make the most of long-stay discounts. Long-stay discounts are applied automatically when you enter your travel dates into the search tool, or you can use the "Weekly stay" and "Monthly stay" filters in your search.
When is the best time to visit Santa Ana for a holiday rental?
January is the most popular time to visit Santa Ana, a charming town in Panamá Province. This month attracts travellers seeking a warm escape, with temperatures typically hovering around the mid-20s Celsius. The pleasant climate allows for comfortable outdoor activities, making it ideal for exploring the vibrant local culture and stunning natural surroundings.

The peak season in Santa Ana runs from July to September, when the town buzzes with visitors eager to experience its beautiful landscapes and rich history. During this time, you can enjoy a variety of activities, from hiking in the nearby hills to soaking up the sun on the beautiful beaches of the Pacific coast. The lively atmosphere fosters opportunities to mingle with fellow adventurers and locals alike.

For those looking for a more budget-friendly option, May presents a wonderful opportunity to explore Santa Ana without the crowds. This month often sees fewer tourists, allowing for a more relaxed experience as you enjoy the tranquil beauty of the region. Plus, the lush greenery following the rainy season creates a picturesque setting, superb for photography and leisurely walks.
Are there any remote work holiday rentals in Santa Ana?
In Santa Ana, Panamá Province, there are numerous remote work holiday rentals available, with around 40 options to choose from. This vibrant area offers a mix of modern comforts and tropical charm, making it an ideal location for those looking to combine work and leisure. Many properties come equipped with essential amenities such as Wi-Fi, dedicated desks, office spaces, and comfortable chairs designed for prolonged use. To help narrow your search, insert your dates and apply the "WiFi" filter on Vrbo.
How early should I book a Santa Ana holiday rental?
Book your Santa Ana holiday rental at least two months before you travel for the best selection of properties.* Plus, you'll typically find that the earlier you book your holiday rental, the better the price.

*Based on analysis of Vrbo booking and occupancy data for 2024 stays.
What are the top attractions in Santa Ana?
In Santa Ana, visitors can take part in the rich history and culture of the area. The vibrant neighbourhood is known for its historic architecture, particularly the beautiful church of San José, which is a significant landmark. Nearby, the Casco Viejo district offers a unique blend of historic charm and modernity, where travellers can explore quaint streets lined with cafes, art galleries, and boutique shops.

The area is also close to the scenic Cinta Costera, a waterfront promenade great for walking or cycling, providing stunning views of the Pacific Ocean and the skyline of Panama City. For those interested in local cuisine, the Mercado de Mariscos (Seafood Market) is a must-visit, offering fresh seafood and a lively atmosphere.
Can I change or cancel my Santa Ana home rental booking on Vrbo?
To find Santa Ana holiday rentals with free cancellation, just use Vrbo's handy "Free cancellation" search filter. We get that plans can change, so it's easy to filter properties that give you flexibility. If you need to make changes to an existing booking, drop your host a message. Go to "My Trips" in your account, click "Change or Cancel" and then "Message Host". Vrbo makes it easy to book with confidence.
Why should I join Vrbo as a host?
Joining Vrbo as a host opens the door to a global community of travellers seeking unique stays, giving you the opportunity to earn income from your property on your terms. With user-friendly tools, dedicated support, and exposure on major travel sites, Vrbo makes it easy to list, manage, and succeed. Whether it's a cosy flat or a countryside retreat, you can turn your space into a standout destination—become a host and let Vrbo handle the heavy lifting to help you thrive.
Are all fees included in the Santa Ana holiday rental prices shown on Vrbo?
Vrbo provides upfront pricing from the moment you start your search. There are no hidden fees added during the check-out process. This allows you to compare properties with ease and plan your trip with confidence.

More holiday ideas