Photo by Cindy Keese
Seneca houses
We found 490 houses — enter your dates for availability
Explore Seneca house rentals
Postcard Cabins Lake Hartwell
Sleeps 4 · 1 bedroom
9.89.8 out of 10
Exceptionalexceptional
20 reviews(20 reviews)
" Estate on the Lake" 7 BR/7 BA, 6 Suites, Over 8,400 Square Feet! Private Pool!
Sleeps 18 · 7 bedrooms · 6+ bathrooms
9.29.2 out of 10
Wonderfulwonderful
249 reviews(249 reviews)
6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
Sleeps 20 · 6 bedrooms · 4+ bathrooms
9.89.8 out of 10
Exceptionalexceptional
148 reviews(148 reviews)
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Sleeps 14 · 7 bedrooms · 4+ bathrooms
1010 out of 10
Exceptionalexceptional
147 reviews(147 reviews)
Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!
Sleeps 8 · 3 bedrooms · 3 bathrooms
1010 out of 10
Exceptionalexceptional
54 reviews(54 reviews)
Beautiful Lake Keowee Flat minutes from Clemson University.
Sleeps 6 · 2 bedrooms · 1 bathroom
1010 out of 10
Exceptionalexceptional
6 reviews(6 reviews)
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Frequently asked questions
Are there any holiday home rentals in Seneca?
Seneca has 490 holiday home rentals to choose from, including in sought-after neighbourhoods like Chickasaw Point. Offering more comfort, privacy and value compared to a hotel room, you'll feel right at home in a Vrbo house.
How much does it cost to stay in a holiday rental house in Seneca?
Whether you're looking for an affordable getaway or an upscale retreat, Vrbo offers a variety of holiday home rentals in Seneca for you to choose from. Use our filter tools to compare options and find the right place for you and your guests.
When is the best time to rent a holiday house in Seneca?
June is when the majority of guests stay in a holiday home rental in Seneca, which is in Oconee County. Average temperatures range from 18ºC (64ºF) to 31ºC (88ºF) during this month.
Where can I rent a Seneca holiday house with great views?
Getting into holiday mode is a breeze when you book one of our Seneca houses with views of historic areas. From adventure-seeking guests to those that prefer to simply kick back, Vrbo has holiday home rentals with vistas guaranteed to impress all types of travellers.
Does Seneca have any weekend house rentals?
Some of Vrbo's holiday houses can be rented just for the weekend, making them perfect for impulsive getaways. Key in your desired travel dates to view the availability. You may need to adjust the dates and be flexible with your travel plans to find the best holiday home rental in Seneca.
Are there any pet-friendly house rentals in Seneca?
Spend your next adventure with your four-legged friend at one of our 13 pet-friendly holiday home rentals in Seneca. These properties feature perks that'll make your pup feel welcome, such as a backyard to play in. Just select the "Pets allowed" filter to book a house that has room for every cherished member of your family.
What are the top things to do in Seneca?
Lake Keowee, Memorial Stadium and South Carolina Botanical Gardens are attractions that'll keep the whole family busy in Seneca. There's nothing like travel to bring everyone together, so browse our holiday home rentals in this lively destination.
Why should I book my holiday rental house with Vrbo?
When you select a Vrbo holiday home rental, the only people you'll share your living space with are those you take with you. It will only be you, your family and the entire property to yourselves. Plus, when you become a member of One Key™ rewards programme, you can earn and spend OneKeyCash™* on eligible bookings on Vrbo. Additionally, our flexible cancellation policies also mean you can book your rental house with confidence should your plans change. *OneKeyCash disclaimer - OneKeyCash is not redeemable for cash and can only be used on Vrbo.