This vacation home accommodates 6 guests with 2 bedrooms and 2 bathrooms. It includes 1 separate living room and offers access to nearby golf and water sports. Enjoy the patio for outdoor relaxation, and take part in adventures like rafting and waterskiing. The property is pet-friendly and located in the city center.
Highlights
Private garden
A rare find — relax in the peaceful, private garden space.
Casa Mamisa offers the perfect blend of Old Town convenience and a peaceful place to retreat after a day of enjoying Key West. Tucked away on a quiet lane just off Duval Street, this two bedroom home puts you close to the heart of the island while giving you a more relaxed setting to come home to.
The open concept kitchen and living area is the heart of the home. The comfortable space features a plush sectional sofa and large Smart TV, creating an inviting place to relax after a day at the beach, exploring Old Town, or enjoying Key West’s restaurants and nightlife. The conveniently stocked kitchen makes it easy to prepare breakfast, enjoy a casual meal at home, or simply keep your favorite snacks and drinks on hand.
Down the hallway, you’ll find two comfortable bedrooms. The guest bedroom features a queen bed with a full bathroom conveniently located nearby. The spacious primary suite features a king bed and private en-suite bathroom with a luxurious walk-in shower.
One of the home’s charming features is the private outdoor space just off the primary suite. Step outside to a cozy backyard area with a porch swing and Weber grill, offering a relaxing spot to enjoy the tropical Key West weather or gather for a casual meal outdoors.
Thoughtful touches throughout the home make it especially comfortable for an extended stay, including cool air conditioning, fast WiFi, eco-friendly bath and cleaning products, and a well stocked kitchen. Everything is designed to give you the comforts of home while you enjoy your time on the island.
And then there’s the location. Just a short stroll from Duval Street, Casa Mamisa makes it easy to experience the best of Key West without spending your vacation in the car. Walk to restaurants, bars, shops, galleries, museums, beaches, and historic landmarks, then return to the quiet lane and settle into your own comfortable retreat.
Whether you’re spending your days exploring Old Town, relaxing at the beach, enjoying the local food scene, or simply embracing the laid back Key West lifestyle, Casa Mamisa gives you a comfortable and inviting place to experience it all.
Our prices include all fees. No hidden fees.
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The host requires you complete the following before checking out:
Load and start the dishwasher
Take out the trash
Turn off the lights and lock the doors
Failure to complete these may result in a negative review from the host.
Important information
You need to know
Property # 4622970
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Onsite parties or group events are strictly prohibited
Host has indicated there is a carbon monoxide detector on the property
Host has indicated there is a smoke detector on the property
Safety features at this property include a fire extinguisher and a deadbolt lock
This property has outdoor spaces, such as balconies, patios, terraces which may not be suitable for children; if you have concerns, we recommend contacting the property prior to your arrival to confirm they can accommodate you in a suitable room
About the neighborhood
Key West
Located near the beach, this vacation home is in Old Town Key West, a neighborhood in Key West. Ernest Hemingway Home and Museum and Fort Zachary Taylor Historic State Park are notable landmarks, and the area's natural beauty can be seen at Florida Keys Beaches and Smathers Beach. Ready for a night out? Consider The Key West Theater and Sloppy Joe's Bar. Jet skiing and kayaking offer great chances to get out on the surrounding water, or you can seek out an adventure with cycling and hiking nearby.
Ernest Hemingway Home and Museum - 5 min walk - 0.4 km
Key West Lighthouse and Keeper's Quarters Museum - 5 min walk - 0.4 km
Mallory Square - 11 min walk - 0.9 km
Southernmost Point - 14 min walk - 1.2 km
Getting around
Key West Intl. Airport (EYW) - 13 min drive
Restaurants
Green Parrot Bar - 2 min walk
801 Bourbon Bar - 3 min walk
Mangoes Restaurant - 1 min walk
Bourbon Street Pub - 2 min walk
Kaya Island Eats - 1 min walk
Frequently asked questions
Is Casa Mamisa - 2 Bedroom Home in Old Town pet-friendly?
Yes, this property allows dogs (limit 1 total).
How much does it cost to stay at Casa Mamisa - 2 Bedroom Home in Old Town?
As of Oct 3, 2026, prices found for a 1-night stay for 2 adults at Casa Mamisa - 2 Bedroom Home in Old Town on Aug 1, 2027 start from $138, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
How much is parking?
Onsite parking is available at the property.
What time is check-in at Casa Mamisa - 2 Bedroom Home in Old Town?
Check-in begins at 4:00 PM.
What time is check-out at Casa Mamisa - 2 Bedroom Home in Old Town?
Check-out is at 10:00 AM.
Where is Casa Mamisa - 2 Bedroom Home in Old Town located?
Located in Old Town Key West, this vacation home is within a 5-minute walk of Duval Street and Ernest Hemingway Home and Museum. Florida Keys Beaches and Mallory Square are also within 15 minutes.
Reviews
9.4
Exceptional
Reviews are presented in chronological order, subject to a moderation process, and verified unless otherwise labeled.
This home was outstanding and very organized. It met all my needs and Alison was very attentive. The location was outstanding highly recommend Kaya’s next foor with the co owner, Scott, being very accommodating. I would rent this place next year in a heartbeat! Thanks for everything!
Stayed 32 nights in Dec 2025
About the host
Hosted by Alison C
Key West has been home to me for more than a decade, and hospitality has been a big part of my career and life on the island. Having worked in hotel management and vacation rental management, I understand what makes a stay feel truly comfortable and what guests need to have a great experience.
I love sharing the best of Key West with visitors, from favorite local restaurants and hidden gems to beaches, sunset spots, and the many unique things there are to do around the island. I’m always happy to offer recommendations or help with anything you need during your stay.
My goal is to make your time in Key West feel easy, comfortable, and memorable, while giving you the opportunity to experience the island like a local.
Why they chose this property
Casa Mamisa is an ideal choice for guests who want to be close to the action of Key West while still having a peaceful and comfortable place to retreat. Tucked away on a quiet lane just off Duval Street, the home offers a wonderful balance of convenience and privacy.
The location makes it easy to explore Old Town on foot, with restaurants, bars, shopping, galleries, museums, beaches, and many of Key West’s most popular attractions just a short stroll away. You can spend the day exploring the island and be back home in minutes.
The home itself is especially comfortable for two couples or a small family, with a king primary suite, queen guest bedroom, two bathrooms, an inviting open living space, and a private outdoor area. The primary suite’s private patio and the backyard porch swing create quiet spots to enjoy the island weather.
With thoughtful amenities, a beautifully appointed interior, and an unbeatable Old Town location, Casa Mamisa offers the convenience of being near everything without feeling like you’re in the middle of it all.
What makes this property unique
Casa Mamisa stands out for its combination of a prime Old Town location and a peaceful, tucked away setting just off Duval Street. You can walk to the best of Key West while still having a quiet place to return to at the end of the day.
The home’s spacious primary suite is a standout feature, with a king bed, luxurious walk in shower, and direct access to a private outdoor space. The backyard adds another layer of charm with a porch swing and Weber grill, creating a relaxed spot for morning coffee or an evening meal outdoors.
Inside, the open kitchen and living area provides a comfortable gathering space, while thoughtful amenities like a well stocked kitchen, fast WiFi, cool AC, and eco friendly bath products make the home particularly well suited for longer stays.
The result is a comfortable Key West home that feels personal and residential, with the convenience of Old Town right outside your door.
Premier Host
They consistently provide great experiences for their guests