Panacea holiday lettings

We found 321 holiday rentals — enter your dates for availability

Select from 158 homes, 27 cottages and other holiday rentals in Panacea to find one that's perfect for your trip. Holiday homes provide the best amenities for your stay with friends, family or just your pet, such as parking and a hot tub. Whatever you're looking for, you'll find a property to rent to meet everyone's needs, including a place that is accessible or non-smoking.

Holiday rentals with weekly discounts - Panacea

Showing deals for:28 Nov - 5 Dec
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Find out more about Panacea

Find out more about Panacea

Why visit Panacea

  • Picturesque Beaches: Enjoy stunning coastal views and relax on the serene sandy shores of Panacea.
  • Outdoor Activities: Engage in a variety of recreational pursuits, from hiking in state parks to water sports.
  • Charming Islands: Explore nearby islands, offering a tranquil escape and beautiful natural scenery.
  • Family-Friendly Atmosphere: Discover welcoming local communities with plenty of activities for all ages.
  • Cozy Accommodation: Choose from a range of delightful vacation rentals, ensuring a comfortable stay.

Popular types of accommodation in Panacea

Panacea offers a delightful selection of vacation rentals, perfect for your next getaway. Whether you fancy a private vacation home, a cosy cottage, or a modern condo, there’s something to suit every taste and budget. Explore our extensive range of Florida vacation rentals to find the ideal base for your adventures, ensuring you enjoy transparency, savings, and peace of mind during your stay.

  • Houses: The top choice for visitors to Panacea, these homes offer a spacious and private environment, ideal for families and groups.
  • Condos: A popular option, condos provide modern amenities and shared facilities, perfect for a comfortable getaway.
  • Cottages: These quaint retreats offer a charming and cosy atmosphere, ideal for a romantic escape or peaceful holiday.
  • Apartments: Convenient and often central, apartments are a practical choice for those wanting to explore the area.
  • Caravan Parks: For a more adventurous stay, caravan parks offer a unique experience with facilities for camping and caravanning enthusiasts.**

Top attractions in Panacea

Panacea, Florida, is an idyllic destination for beach and outdoor enthusiasts seeking stunning scenery. Visitors can explore a variety of attractions, including picturesque beaches, charming islands, and beautiful state parks. Whether you're after a coastal getaway or local points of interest, Panacea offers a delightful range of activities in a serene natural setting, making it the perfect spot to unwind and enjoy the great outdoors.

  • Alligator Point Beach: A serene stretch of sandy shoreline perfect for sunbathing and beachcombing, Alligator Point Beach offers a relaxed atmosphere with stunning views of the Gulf of Mexico. Enjoy gentle waves and opportunities for birdwatching.
  • Bald Point State Park: This picturesque state park is an outdoor enthusiast's paradise, featuring hiking trails, scenic vistas, and abundant wildlife. Explore the diverse ecosystems and enjoy activities like fishing and kayaking.
  • USS Mohawk CGC Veterans Memorial Reef: A unique underwater attraction, this historic site is a submerged Coast Guard cutter that serves as an artificial reef, fostering marine life and providing a memorable diving experience, steeped in maritime heritage.

Things to do recommended for couples

Seeking a romantic getaway in Panacea? Enjoy a leisurely stroll on the pristine beaches, explore the serene Wakulla Springs, or indulge in a candlelit dinner at a charming local restaurant. Unwind together while watching the stunning sunset over the Gulf of Mexico.

Things to do recommended for families

Families visiting Panacea can enjoy a relaxing day at Woolley Park, perfect for unwinding. Just a short drive away, Myron B Hodge City Park and Morrison Hammock Scenic Area offer stunning scenery and more opportunities for wellness and relaxation, making them great choices for family activities.

Things to do recommended for groups

Enjoy a round of golf at St. James Bay Golf Club, set 8.1km from Panacea, where you can soak up the outdoor sports atmosphere with your friends. It’s a perfect spot for friendly competition and relaxation amidst beautiful surroundings.

What do I need to keep in mind when booking a vacation in 'Panacea

If you’re travelling with a group, family, or pets, or if you’re seeking extended stays, it’s important to apply the appropriate filters to meet your needs. Here are some helpful Vrbo booking tips for you.

  • Traveling to Panacea with a group: Think about how many bedrooms you require, as well as features like a fully equipped kitchen or outdoor space for group gatherings. Thankfully, you can easily filter for these options and many more on Vrbo.
  • Traveling to Panacea with young kids: Travelling with young children can present its own set of challenges. It's important to prioritise their comfort and safety, alongside suitable facilities like a private swimming pool. Additionally, considering your closeness to family-friendly attractions is highly advisable.
  • Taking your pets with you to Panacea: For many families, a getaway isn't truly fulfilling without their furry companion by their side. If this resonates with you, take a look at Vrbo properties that welcome pets. Most of these pet-friendly accommodations offer feeding bowls and beds, ensuring that every member of the family feels comfortable and at home.
  • Planning for a long term stay visiting Panacea: If you're in search of holiday rentals offering discounts for stays of a month or more, you've come to the perfect spot. By using the appropriate filter, you can effortlessly discover and save on monthly accommodations. Don't forget to include features such as a parking space, a well-equipped kitchen, or a private pool in your search criteria as well.

Where to stay in Panacea

Panacea, Florida, offers a delightful escape for those seeking a beach getaway with stunning sea views and cozy retreats. This charming destination boasts a relaxing atmosphere, perfect for unwinding and enjoying the outdoors. Nearby, you'll find family-friendly areas with plenty of recreational activities and friendly locals. Whether you’re lounging on the beach or exploring the scenic surroundings, Panacea promises a memorable holiday filled with tranquillity and fun.

  • Alligator Point: Nestled along the Gulf Coast, Alligator Point is a charming village known for its stunning beaches and picturesque scenery. This tranquil destination is perfect for those seeking outdoor adventures, with opportunities for fishing, kayaking, and relaxing on the sandy shores. Visitors can explore nearby recreational areas and resorts, as well as enjoy a round of golf at the local course. Alligator Point is also in close proximity to a national state park and wetland areas, making it an ideal spot for nature lovers and birdwatchers alike.
  • Saint Teresa: Located just a stone's throw from Panacea, the village of Saint Teresa offers a serene beach experience, making it a popular escape for tourists. The area is perfect for outdoor activities, including golf and leisurely strolls along the waterfront. With its lush landscapes and recreational areas, it’s an idyllic setting for relaxation and adventure. Nearby attractions include beautiful beaches and protected wetlands, giving visitors a chance to immerse themselves in the area's natural beauty while enjoying the peaceful atmosphere.
  • Ochlockonee Bay: This vibrant village is renowned for its adventurous spirit, offering a captivating blend of outdoor activities and scenic views. Ideal for those who enjoy fishing, boating, and hiking, Ochlockonee Bay is a gateway to an array of recreational opportunities. The local golf course provides a fantastic place to unwind after a day of exploring. With the Gulf's shimmering waters and nearby national state parks and wetlands, Ochlockonee Bay promises an exciting and picturesque getaway for all nature enthusiasts.

Best time to go to Panacea

If you're planning a trip to Panacea, it's a good idea to check both the weather and property rates. The warmest months are July and August. Peak season runs in April and June to July, while off-peak times, like October to December tend to have fewer bookings and better deals.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January53.6°F (12.0°C)Light RainMostly SunnyAverageSlightly Low
February57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly Low
March62.4°F (16.9°C)Light RainMostly SunnyAverageSlightly Low
April68.2°F (20.1°C)Light RainMostly SunnyModerately HighAverage
May74.8°F (23.8°C)Light RainMostly SunnyAverageSlightly High
June80.4°F (26.9°C)Moderate RainMostly SunnyModerately HighSlightly High
July81.7°F (27.6°C)Moderate RainMostly SunnyModerately HighSlightly High
August81.7°F (27.6°C)Moderate RainMostly SunnyAverageAverage
September78.4°F (25.8°C)Light RainMostly SunnyAverageAverage
October71.1°F (21.7°C)Light RainMostly SunnyModerately LowAverage
November61.9°F (16.6°C)Light RainMostly SunnyModerately LowAverage
December57.6°F (14.2°C)Light RainMostly SunnyModerately LowAverage

Booking with Vrbo is simple

Are you aiming to make some savings on your upcoming getaway? Being flexible with your travel dates can be beneficial, as prices often fluctuate. Additionally, you could enjoy considerable discounts by opting for a longer stay. To discover a Vrbo property that suits your budget, utilise our filters to sort by price, location, and type of holiday rental.

Vrbo Trips: Effortless planning

Vrbo's Trip Board offers a user-friendly platform where you can plan new adventures, resume previous ones, or manage your travel arrangements with ease. You'll discover your saved or booked properties neatly organised under the categories of Potential, Upcoming, or Current Trips. To begin exploring Trip Boards, please visit: https://www.vrbo.com/en-gb/trips.

**Based on Vrbo properties bookings.

Why people love visiting relaxing Panacea

The beaches and wildlife provide a pleasant backdrop to your holiday home in Panacea. Well known for its dolphin watching, seafood restaurants and fishing, this relaxing city won't disappoint. With a holiday rental, you get a home away from home – many rentals offer full kitchens and outdoor grills for some home cooking.

Activities and attractions in Panacea

Do you want to discover top things to see and do in the city? You'll be sure to enjoy Panacea for its dolphin viewing and fishing. Although it can be tempting to stay in your comfortable holiday rental, you'll want to check out everything that makes Panacea a fun spot to go on holiday. Here are some of the most popular attractions to explore, all within 30 miles (48.2 km) of the city centre:

  • St. James Bay Golf Club (13 mi / 21 km)
  • Wildwood Golf Club (7.3 mi / 11.7 km)
  • Gulf Specimen Public Aquarum (0.8 mi / 1.2 km)

Exploring the natural landscape of Panacea

Whether you're an active traveller or just want to appreciate the scenery, Panacea is a great place to spend some time outside. Here are some of the area’s most enchanting sights, all within 30 miles (48.2 km) of the city centre:

  • Mashes Sand Beach (5.1 mi / 8.2 km)
  • Shell Point Beach (6.7 mi / 10.8 km)
  • Wilson Beach (7.4 mi / 11.9 km)
  • Alligator Point Beach (8.3 mi / 13.3 km)
  • Bald Point State Park (9 mi / 14.6 km)
  • Apalachicola National Forest (16.3 mi / 26.2 km)

Seasonal weather averages in Panacea

If warm-weather activities are high on your list, July, August, June and September are the hottest months to visit, when temperatures average 27°C.

How to get to and around Panacea

The nearest airport is in Tallahassee, FL (TLH-Tallahassee Intl.), located 25.5 mi (41.1 km) from the city centre.

Frequently asked questions

What is the best area to stay in Panacea when booking a holiday rental?
When considering a holiday rental in Panacea, Florida, the best area to stay is near the coastline, particularly around the scenic Bald Point State Park. This picturesque neighbourhood offers a range of properties, from charming cottages to spacious beachfront homes, allowing visitors to immerse themselves in the natural beauty of the region. With its stunning views of the Gulf of Mexico and easy access to pristine beaches, this area is great for those looking to unwind and enjoy the outdoors.

A highlight of staying near Bald Point State Park is the opportunity to explore the diverse ecosystems, including salt marshes and coastal forests. The park is a haven for wildlife enthusiasts, providing excellent birdwatching opportunities and a chance to spot dolphins in the nearby waters. Additionally, the proximity to the quaint town of Panacea means you can easily enjoy local dining options and experience the warm hospitality of the area.

Another appealing neighbourhood is the area surrounding the Apalachicola National Estuarine Research Reserve. Staying here offers a unique blend of recreational activities and natural exploration. Visitors can enjoy kayaking, fishing, and hiking, making it an ideal spot for those who appreciate the great outdoors. The reserve is not only a beautiful space but also a point of interest for those keen on learning about the local ecosystem.
How much does it cost to rent a holiday home in Panacea?
Prices for holiday rentals in Panacea vary based on factors like travel dates, length of stay, accommodation type, and location. Simply enter your trip details to explore a wide range of options—whether you're traveling solo, as a couple, with family, or in a group. Vrbo offers something for every taste and budget, from affordable rentals in Panacea to more spacious homes. To get the best value, book early and take advantage of Vrbo's free rewards program.
Are there any discounts for Panacea holiday house rentals?
You can find great discounts on house rentals in Panacea on Vrbo, including special rates on new listings and savings for weekly or monthly stays with top amenities such as a pool or parking. There are several discounts for Last minute bookings, and Early bird bookings too. The best part is, there's no need for a discount code—just enter your travel dates and apply the discount filters to view the top rates.
Where are the best areas for renting a beach house in Panacea?
For renting a beach house in Panacea, Florida, the coastal area near the Apalachicola National Estuarine Research Reserve is an excellent choice. This region offers access to beautiful sandy shores and serene natural landscapes, making it ideal for travellers seeking a relaxing beach getaway. Many holiday rentals in this area come equipped with amenities such as private decks, outdoor grilling facilities, and fully stocked kitchens, allowing guests to enjoy meals while taking in the picturesque views.

Additionally, the nearby St. George Island is a prominent destination for beach house rentals, featuring properties that often include spacious living areas, access to beach equipment, and outdoor showers for rinsing off after a day spent by the water. These rentals typically provide a blend of comfort and convenience, suiting both families and groups.
What is the most popular type of holiday rental accomodation in Panacea?
In Panacea, holiday houses are the most popular type of rental, with around 154 available throughout the area. These properties often feature spacious layouts, multiple bedrooms, fully equipped kitchens, and outdoor spaces where guests can enjoy the warm Florida weather. Many holiday houses are situated close to natural attractions like the Ochlockonee River and nearby beaches, making them superb for families or groups looking to explore the region. Additionally, there are about 24 charming cottages and several condos and apartments that offer a cozier stay, often featuring amenities like pools or communal areas.
Are there any family house rentals in Panacea?
In Panacea, Florida, there are numerous family-friendly house rentals available, with around 133 options to choose from. This charming coastal area is known for its picturesque scenery and access to outdoor activities, making it an excellent choice for families. Many of these homes offer spacious living areas and fully equipped kitchens, allowing families to prepare meals together.
Can I rent a holiday home with a pool or hot tub in Panacea?
In Panacea, Florida, there are several holiday homes available for rent that include pools and hot tubs, with around 37 options to choose from. This charming coastal town offers a laid-back atmosphere and proximity to beautiful beaches, making it an ideal getaway for travellers seeking relaxation. Many of these properties feature private pools, hot tubs, and spacious outdoor areas, great for soaking up the sun or enjoying evening gatherings. Additionally, you'll often find fully equipped kitchens, allowing for convenient self-catering during your stay.
Can I find long-stay holiday rentals in Panacea?
A long-stay holiday rental in Panacea is the best way to experience local living. Plus, you can make the most of long-stay discounts. Long-stay discounts are applied automatically when you enter your travel dates into the search tool, or you can use the "Weekly stay" and "Monthly stay" filters in your search.
Are there pet-friendly house rentals in Panacea?
In Panacea, there are a variety of pet-friendly house rentals available, offering a welcoming environment for travellers with furry companions. Many of these rentals feature amenities such as spacious outdoor areas, fully equipped kitchens, and comfortable living spaces, superb for families or groups looking to unwind.
Are there any remote work holiday rentals in Panacea?
In Panacea, Florida, there are plenty of remote work holiday rentals available, with around 173 properties suiting those looking to blend work and leisure. Many of these accommodations are equipped with essential amenities for remote work, including Wi-Fi, dedicated desk spaces, and comfortable office chairs. Some properties also offer additional features such as laptop workspaces and computer monitors, providing a conducive environment for productivity. To help narrow your search, insert your dates and apply the "WiFi" filter on Vrbo.
Are there any Panacea holiday rentals with parking?
Vrbo offers a wide selection of holiday rentals in Panacea with parking available—perfect for families or travellers who value the convenience of having a car during their stay. To easily find these properties, simply enter your travel details on Vrbo and use the "Parking available" filter under the amenities section. This makes it quick and easy to browse listings that suit your needs, whether you're planning a short city break or a longer stay.
What are popular rental amenities in Panacea?
In Panacea, popular holiday rental amenities include fully equipped kitchens, allowing guests to prepare their own meals with ease. Most rentals come with essential cookware, dishware, and utensils, as well as modern appliances such as refrigerators and microwaves. These conveniences enhance the home-like experience while exploring the natural beauty of the Florida coast.
When is the best time to visit Panacea for a holiday rental?
The most popular time to visit Panacea is during the peak season from April to June. This vibrant period attracts holidaymakers looking to soak up the sun, enjoy outdoor adventures, and relax by the beautiful Gulf Coast. The warm temperatures, often reaching the mid to high 20s Celsius, create an inclusive setting for beach activities and water sports, making it an ideal time for families and groups seeking a fun getaway.

April marks the beginning of this bustling season, with visitors enjoying mild weather and fewer crowds compared to the height of summer. As you explore the stunning landscapes, you can partake in activities such as kayaking in the nearby waterways or birdwatching in the wildlife-rich area, all while appreciating the scenic beauty that Panacea has to offer.

For those looking for a more budget-friendly option, consider visiting in November. This month provides a lovely opportunity to experience the quieter side of Panacea, where you can enjoy pleasant temperatures and fewer tourists while still taking in the natural beauty of the area. The less crowded beaches and tranquil setting create a superb backdrop for leisurely strolls and peaceful relaxation.
How early should I book a Panacea holiday rental?
Book your Panacea holiday rental at least two months before you travel for the best selection of properties.* Plus, you'll typically find that the earlier you book your holiday rental, the better the price.

*Based on analysis of Vrbo booking and occupancy data for 2024 stays.
Can I change or cancel my Panacea home rental booking on Vrbo?
To find Panacea holiday rentals with free cancellation, just use Vrbo's handy "Free cancellation" search filter. We get that plans can change, so it's easy to filter properties that give you flexibility. If you need to make changes to an existing booking, drop your host a message. Go to "My Trips" in your account, click "Change or Cancel" and then "Message Host". Vrbo makes it easy to book with confidence.
Why should I join Vrbo as a host?
Joining Vrbo as a host opens the door to a global community of travellers seeking unique stays, giving you the opportunity to earn income from your property on your terms. With user-friendly tools, dedicated support, and exposure on major travel sites, Vrbo makes it easy to list, manage, and succeed. Whether it's a cosy flat or a countryside retreat, you can turn your space into a standout destination—become a host and let Vrbo handle the heavy lifting to help you thrive.
Are all fees included in the Panacea holiday rental prices shown on Vrbo?
Vrbo provides upfront pricing from the moment you start your search. There are no hidden fees added during the check-out process. This allows you to compare properties with ease and plan your trip with confidence.

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