East Florence vacation rentals
We found 20 vacation rentals — enter your dates for availability
Discover a selection of 6 homes and other vacation rentals in East Florence that are perfect for your trip. Whether you're staying in a vacation rental with your kids and pets or just with friends, you'll find the best amenities for hanging out with the people that matter most, such as parking and air conditioning. What you'll find is a rental that has what everyone needs, including places that are non-smoking or accessible.
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Find the best place to stay - East Florence
New Upgrades, Boat Parking, Fenced Yard, Pet & Family Friendly by River Hospital
Sleeps 6 · 3 bedrooms · 1+ bathroom
9.69.6 out of 10
Exceptionalexceptional
60 reviews(60 reviews)
ReNew At JW's & bring your Dog too!
Sleeps 6 · 2 bedrooms · 1 bathroom
1010 out of 10
Exceptionalexceptional
1 review(1 review)
Waterfront Florence Home w/ Private Dock!
Sleeps 8 · 4 bedrooms · 2 bathrooms
9.69.6 out of 10
Exceptionalexceptional
15 reviews(15 reviews)
Cheerful Wishes- 3 Bedroom House To Yourself
Sleeps 7 · 3 bedrooms · 1 bathroom
8.48.4 out of 10
Very Goodvery good
18 reviews(18 reviews)
House Near UNA, Downtown, River, Middle of Florence, Long term welcome, Clean
Sleeps 6 · 3 bedrooms · 1 bathroom
9.09.0 out of 10
Wonderfulwonderful
6 reviews(6 reviews)
Magnolia at The Shoals: Lakefront Home on Wilson Lake
Sleeps 12 · 4 bedrooms · 2 bathrooms
1010 out of 10
Exceptionalexceptional
99 reviews(99 reviews)
Top rated rentals - East Florence
Work trip in Florence
1010 out of 10
Exceptionalexceptional
1 review(1 review)
Loved this little house. It had everything I needed and was close to my work. Majority of my stay I was alone and I felt totally safe. Definitely recommend this place!
Kim R.
Stayed Apr 2025
One of the best places to stay in Florence!
1010 out of 10
Exceptionalexceptional
21 reviews(21 reviews)
10/10 in all ways. Very nice newer home with all of the amenities. Would definitely stay again!
Tim M.
Stayed Aug 2024
Getaway
1010 out of 10
Exceptionalexceptional
1 review(1 review)
The hone was very beautiful and quiet. It was secluded yet just seconds away from shopping, boating and restaurants.
Ricky B.
Stayed Jul 2024
Downtown Charming Triplex
9.89.8 out of 10
Exceptionalexceptional
7 reviews(7 reviews)
Very roomy and accommodating! Each couple had their privacy and the cental gathering space was awesome!
Amanda T.
Stayed Jun 2025
My friend's birthday
9.89.8 out of 10
Exceptionalexceptional
20 reviews(20 reviews)
Love the place ,my second time. Will be staying there again. Thank you for the wonderful stay.
Paula H.
Stayed Apr 2025
Great apartment and location
9.69.6 out of 10
Exceptionalexceptional
21 reviews(21 reviews)
Clean, plenty of amenities
Matthew G.
Stayed Jun 2025
Relaxing stay in Florence
9.69.6 out of 10
Exceptionalexceptional
15 reviews(15 reviews)
Great house on the water in quiet neighborhood. We were in town for a wedding. House was clean and bigger than it appears in pics. Nice kitchen. Nice porch overlooking water. Neighborhood was great for our morning walks. Quick drive to center of town and the university.
Christopher
Stayed Jun 2025
Great location!
9.69.6 out of 10
Exceptionalexceptional
31 reviews(31 reviews)
Location was great! Very close to gas, groceries, shopping. Fully stocked kitchen, tv with apps that we could log into for our shows, great A/C (I'm always hot!) Easy access with the keyless entry. Would definitely recommend!
DeVona
Stayed Sep 2024
Peace of mindOur Book with Confidence guarantee gives you 24/7 support
All the privacy of homeEnjoy full kitchens, laundry, pools, yards and more
More for lessMore space, more privacy, more amenities — more value
Frequently asked questions
How much does it cost to rent a vacation rental in East Florence?
Length of stay, season and property type are some things that can affect the price of a vacation home. Simply enter your dates of travel to find your ideal escape. From cozy cabins to sprawling villas, all Vrbo vacation rentals offer terrific value.
How much does it cost to rent a beach house in East Florence?
When you travel and the style and size of the property will influence the cost of your beachside stay. Enter your East Florence travel dates to see your options on Vrbo. Did someone just say "private pool"? Use the filters to choose the features and amenities you want in your rental.
Are there pet-friendly vacation rentals in East Florence?
With four properties that allow pets, your little buddy can join you on your East Florence break. Use the filter tool to search our pet-friendly vacation rentals and find a vacation home that'll set tails wagging on Vrbo.
What are popular rental amenities in East Florence?
When it comes to rental amenities that guests prefer in East Florence, a garden, a barbecue grill and a fireplace are at the top of the list. With Vrbo vacation rentals, you'll discover options to suit your style and taste, whether you're taking a trip with your partner, your friends or even pets.
Are there large group vacation rentals in East Florence?
With four East Florence vacation rentals that can accommodate five or more people, you can bring a few extra family members or pals along. Whether you're planning a casual get-together or a special celebration, Vrbo will help you find the perfect space to match the occasion.
Are there vacation rentals in East Florence that welcome kids?
With four family-friendly vacation properties available in East Florence, now is a fantastic time to introduce the kids to the magic of travel. Just click on our "Properties good for families" filter box to browse stays loaded with amenities ideal for traveling families, such as dining rooms, swimming pools, hot tubs and entertainment areas.
What are the top attractions for families in East Florence?
If you've got the little ones in tow, stick these family-friendly attractions in East Florence on your must-see list:
- Renaissance Tower
- River Heritage Park
Are there vacation rentals with WiFi in East Florence?
You can choose from two vacation rentals with WiFi in East Florence. If you'd like to disconnect from daily life during your trip, but still need to be connected to the internet, these properties have just what you need. Narrow your search by applying the WiFi filter on Vrbo.
How can I find vacation rentals with air conditioning in East Florence?
Pick your dates and then make use of our filters to see vacation rentals with ac in East Florence on Vrbo. With four air-conditioned properties available here, you can look forward to a comfy and cool stay.
How old do you have to be to rent a vacation rental in East Florence?
The minimum required age is normally 16, 18 or 21. It can differ from property to property on Vrbo, so check the rules of your chosen East Florence vacation home before booking.
How long can I rent a vacation rental in East Florence for?
The amount of time you can book an East Florence vacation rental for differs depending on the property. Just tap in your travel dates to see available options that offer extended stays. They feature the things you need to make your extended getaway more convenient and enjoyable, such as laundries and air conditioning. Some vacation homes may also offer discounted weekly or monthly prices, so you can stay even longer for less.
Does Vrbo offer discounts for vacation homes in East Florence?
Whether you've got your sights set on one of our newly listed homes, or one of our weekly or monthly discounts on vacation rentals, you're sure to find some fabulous bargains and discounts on Vrbo. From weekend retreats to extended getaways, we've got the ideal space for your next East Florence escape.