Pros:
Beautiful house, best on the street. Amazing, Incredibly responsive hosts -- immediately addressed problems (even after one issue went away, they still sent someone to be sure) and super communication.
Best stocked house EVER. Not only everything we could need or want but also tons of spices, sugar, coffee etc. even some vodka -- great "toys" too (bikes and kayaks even though we didn't use)
Great wifi
Easy canal in & out of ocean (we rented a boat for our stay and it was SO EASY)
Obviously recently renovated and beautiful bathrooms / hard wood floors
Quiet -- when many houses in Islamorada are closer to main highway and traffic noise
Great outdoor spaces, upstairs coffee deck, main level cocktails deck, downstairs outside eating
comfortably fit larger group for daytime hanging / eating / etc EXCEPT for sleeping (more on that below)
Perfect location to great restaurants and bars and many options -- this in our opinion is the best section of Islamorada and the best part of the Keys! And owners gave GREAT recommendations!
Fresh lobster down the street!
Occasional Manatee off the dock!
Cons / Really Wish We'd Known or someone else had mentioned to us:
Third downstairs "bedroom" really only suitable for kids in our opinion. It has three twin beds but no bathroom -- so when we had two middle-aged couples to visit, one couple lived like kings in the gorgeous main floor "second master bedroom", the other couple drew the short straw in the lower level (they called it the dungeon) where they had to make their way upstairs in the middle of the night to pee. We mistakenly thought both guest bedrooms were somehow next to one another with a shared bathroom between them (description didn't clarify no bathroom for the third guest bedroom / on a different floor). If you have kids and/or only two adult couples staying then you are set!! Three couples were an issue (for us).
No door to 3rd floor upstairs master made it rather loud upstairs as a result. Remote working, one of us had to go to the lower level and the other on top level for Zoom calls because you can hear everything on top floor without a door to close.
No sun on pool area as someone else in reviews noted, but we were there to work, so not a big deal. Few other minor issues but immediately resolved.
House overall was lovely and we'd recommend for a couple or family with kids who can bunk in lower level. Thanks!!