Panacea vacation rentals

We found 314 vacation rentals — enter your dates for availability

Discover a selection of 159 homes, 17 apartments, and other vacation rentals in Panacea that are perfect for your trip. Vacation homes offer the amenities you expect for your stay with friends, family, or just your pet, such as WiFi and a pool. At the end of the day, you're sure to find a rental to meet everyone's needs, including a place that is accessible or non-smoking.

Vacation rentals with weekly discounts - Panacea

Showing deals for:Mar 20 - Mar 27

Image gallery for Nothing Between You, the Gulf of Mexico and Amazing Sunrises!

View of the cottage from the West - Decks and porch face east and south
9.8 out of 10, Exceptional, (72 reviews)
Exceptional
(72 reviews)

Nothing Between You, the Gulf of Mexico and Amazing Sunrises!

Crawfordville

9% off
Price is $187
$1,310 for 7 nights
All fees included
Nothing Between You, the Gulf of Mexico and Amazing Sunrises!

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Find out more about Panacea

Why visit Panacea

  • Beautiful Beaches: Enjoy the stunning coastline and relax on the sandy shores of Panacea.
  • Outdoor Activities: Engage in various recreational activities like hiking, fishing, and kayaking in the nearby state parks.
  • Charming Neighborhoods: Explore the friendly local atmosphere and picturesque surroundings that offer a laid-back vibe.
  • Diverse Accommodations: Choose from cozy vacation rentals, stylish condos, or charming cottages tailored to your needs.
  • Scenic Islands: Discover nearby islands that provide a serene escape for nature lovers and beach enthusiasts.

Popular types of accommodation in Panacea

Panacea Vacation Rentals offers a variety of accommodations to suit every traveler's needs. Whether you're looking for a cozy private vacation home, a stylish condo, or a charming cottage, we have you covered. Our friendly house rentals and motels provide the perfect base for your adventures. Explore the beauty of Panacea with confidence, knowing you have a range of options to choose from for your stay.

  • Houses: The top choice for travelers in Panacea, these homes offer a spacious and comfortable atmosphere, perfect for families or groups.
  • Condos: A popular second option, condos provide convenient amenities and often stunning views, ideal for a relaxed getaway.
  • Cottages: These charming retreats are a cozy third choice, perfect for a romantic escape or a peaceful solo retreat.
  • Apartments: A versatile fourth option, apartments offer a home-like environment with essential conveniences for your stay.
  • Caravan Parks: Rounding out the list, caravan parks provide a unique outdoor experience, perfect for nature enthusiasts.**

Top attractions in Panacea

Panacea, Florida, is an idyllic destination for beach lovers and outdoor enthusiasts seeking scenic beauty. With its stunning beaches, nearby state parks, and charming islands, visitors can immerse themselves in nature and enjoy a variety of recreational activities. Whether you're traveling solo, with family, or as a couple, Panacea offers a perfect getaway for those looking to unwind and explore the great outdoors.

  • Alligator Point Beach: A serene beach located within Panacea, Alligator Point Beach offers a laid-back atmosphere perfect for sunbathing, swimming, and enjoying picturesque sunsets. The soft sands and gentle waves create an inviting environment for relaxation.
  • Bald Point State Park: This stunning state park features diverse ecosystems, scenic views, and numerous trails for outdoor activities. Enjoy hiking, birdwatching, and picnicking while surrounded by nature's beauty, making it ideal for adventure seekers.
  • Hopkins Island: Accessible only by boat, Hopkins Island boasts pristine beaches and lush landscapes. Ideal for outdoor enthusiasts, visitors can explore its natural beauty, enjoy beach activities, and experience solitude amidst the tranquil surroundings.

Things to do recommended for couples

For a romantic getaway in Panacea, enjoy a sunset stroll on the beautiful beaches, savor fresh seafood at local diners, or explore the scenic trails at nearby parks. Don't forget to visit the quaint shops for unique souvenirs and take a kayak tour through the stunning coastal waters.

Things to do recommended for families

Families visiting Panacea can enjoy a relaxing day at Woolley Park, explore the scenic beauty of Morrison Hammock Scenic Area just 7 miles away, and unwind at Myron B Hodge City Park, located 6 miles from town. Each location offers a perfect blend of fun and relaxation.

Things to do recommended for groups

Groups visiting Panacea can enjoy a round of golf at the scenic St. James Bay Golf Club, located 13 miles away. This course offers a fantastic outdoor atmosphere perfect for bonding and relaxation amidst beautiful landscapes.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

What do I need to keep in mind when booking a vacation in Panacea

If you're traveling with a group, family, or pets, or if you're seeking extended stays, be sure to prioritize your filters accordingly. Here are some helpful Vrbo booking tips for you.

  • Traveling to Panacea with a group: Think about how many bedrooms you'll require and any additional amenities like a full kitchen or outdoor space for gatherings. Luckily, you can easily filter for these options and more on Vrbo.
  • Traveling to Panacea with young kids: Traveling with young kids can be quite a task. It's important to prioritize their comfort and safety, along with having suitable amenities like a private swimming pool. Additionally, it’s wise to think about how close you are to family-friendly attractions.
  • Taking your pets with you to Panacea: For many families, a getaway isn't truly a getaway without their furry companion. If that resonates with you, explore Vrbo listings that welcome pets. Many of these pet-friendly properties come equipped with feeding bowls and cozy beds, ensuring that everyone feels at home.
  • Planning for a long term stay visiting Panacea: If you’re in search of vacation rentals with special offers for extended stays of a month or more, you’ve come to the right spot. By using the appropriate filters, you can effortlessly discover and save on monthly rentals. Don’t forget to include options like a parking space, a great kitchen, or a private pool in your search as well.

Where to stay in Panacea

Panacea, Florida, is a hidden gem perfect for those seeking a peaceful getaway amidst stunning natural landscapes. With its beautiful beaches and serene outdoor settings, visitors can indulge in relaxation and recreation. Nearby cities offer a family-friendly atmosphere, friendly locals, and breathtaking scenic views. Explore the charming surroundings to truly experience the laid-back vibe and tranquility that Panacea has to offer.

  • Alligator Point: Nestled along the Gulf Coast, Alligator Point is a serene village that offers a perfect blend of natural beauty and outdoor adventure. Known for its stunning beaches and picturesque scenery, visitors can enjoy activities such as fishing, kayaking, and sunbathing. The area features recreational facilities, a golf course, and various resorts, making it an excellent destination for relaxation. Nearby attractions include a national state park and wetlands, providing opportunities for wildlife observation and exploring the region's unique ecosystems.
  • Saint Teresa: Located close to Panacea, Saint Teresa is another charming village that captivates travelers with its tranquil beaches and scenic landscapes. This area is ideal for outdoor enthusiasts, offering golf courses and recreational spaces that encourage active lifestyles. Visitors can explore the nearby national state park and wetlands, where they can take in the natural beauty and diverse wildlife. Whether you're seeking a peaceful day at the beach or engaging in outdoor sports, Saint Teresa provides a delightful getaway.
  • Ochlockonee Bay: Known for its adventurous spirit, Ochlockonee Bay is a vibrant village that offers an array of outdoor experiences. Its scenic views and recreational areas make it a favorite among nature lovers and thrill-seekers alike. Visitors can indulge in activities such as fishing, boating, and golfing while enjoying the bay's coastal charm. The proximity to a national state park and wetlands allows for exploration of diverse flora and fauna, making it a fantastic spot for eco-tourism enthusiasts.

Best time to go to Panacea

If you're planning a trip to Panacea, it's a good idea to check both the weather and property rates. The warmest months are July and August. Peak season runs in April and June to July, while off-peak times, like October to December tend to have fewer bookings and better deals.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January53.6°F (12.0°C)Light RainMostly SunnyAverageSlightly Low
February57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly Low
March62.4°F (16.9°C)Light RainMostly SunnyAverageSlightly Low
April68.2°F (20.1°C)Light RainMostly SunnyModerately HighAverage
May74.8°F (23.8°C)Light RainMostly SunnyAverageSlightly High
June80.4°F (26.9°C)Moderate RainMostly SunnyModerately HighSlightly High
July81.7°F (27.6°C)Moderate RainMostly SunnyModerately HighSlightly High
August81.7°F (27.6°C)Moderate RainMostly SunnyAverageAverage
September78.4°F (25.8°C)Light RainMostly SunnyAverageAverage
October71.1°F (21.7°C)Light RainMostly SunnyModerately LowAverage
November61.9°F (16.6°C)Light RainMostly SunnyModerately LowAverage
December57.6°F (14.2°C)Light RainMostly SunnyModerately LowAverage

Booking with Vrbo is simple

Looking to save on your next trip? Consider being flexible with your travel dates, as prices can fluctuate. Plus, extending your stay can lead to significant savings. To discover the ideal Vrbo property that fits your budget, utilize our filters to narrow down your search by price, location, and type of vacation rental.

Save more with One Key

Reserve a qualifying Vrbo for your group getaway and earn OneKeyCash on your booking. Being the planner has its perks. When you join our travel rewards program, OneKey, you'll gain immediate access to member discounts and the ability to earn and redeem OneKeyCash on eligible reservations. Sign up now and begin enjoying the savings.

Vrbo Trips: Planning made easy

Vrbo’s Trip Board provides a convenient platform for you to plan new trips, keep your travel arrangements on track, or manage your existing bookings. Your saved or reserved properties are neatly categorized into Potential, Upcoming, or Current Trips for easy access. To discover more about Trip Boards, please visit: https://www.vrbo.com/trips.

**Based on Vrbo properties bookings.

Why people love visiting tranquil Panacea

The beaches and wildlife provide a pleasant backdrop to your vacation home in Panacea. Well known for its dolphin watching, seafood restaurants and fishing, this relaxing city won't disappoint. With a vacation rental, you get a home away from home. Many rentals offer full kitchens and outdoor grills for some home cooking.

Activities and attractions in Panacea

Are you hoping to find attractions to see during your stay? You'll be sure to enjoy Panacea for its dolphin viewing opportunities and fishing. Although it can be tempting to stay in your comfortable vacation rental, you'll want to check out everything that makes Panacea a one-of-a-kind vacation spot. Here are some of the major attractions to see, all within 30 miles (48.2 km) of the city center:

  • St. James Bay Golf Club (13 mi / 21 km)
  • Wildwood Golf Club (7.3 mi / 11.7 km)
  • Gulf Specimen Public Aquarum (0.8 mi / 1.2 km)

Exploring the natural landscape of Panacea

Whether you're an outdoor enthusiast or just want to spend some time taking in the scenery, Panacea is a great place to get out in nature. These are a few of the area's noteworthy features, all within 30 miles (48.2 km) of the city center:

  • Mashes Sand Beach (5.1 mi / 8.2 km)
  • Shell Point Beach (6.7 mi / 10.8 km)
  • Alligator Point Beach (8.3 mi / 13.3 km)
  • Bald Point State Park (9 mi / 14.6 km)
  • Apalachicola National Forest (16.3 mi / 26.2 km)
  • St. Marks National Wildlife Refuge (17.2 mi / 27.7 km)

Seasonal weather averages in Panacea

If warm-weather activities are high on your list, July, August, June and September are the hottest months to visit, when temperatures average 81°F.

How to get to and around Panacea

The nearest airport is in Tallahassee Intl. Airport (TLH), located 25.5 mi (41.1 km) from the city center.

Frequently asked questions

What is the best area to stay in Panacea when booking a vacation rental?
When looking for the best area to stay in Panacea, Florida, consider focusing on the waterfront locations along the scenic coastal routes. This area offers a tranquil atmosphere that is great for a relaxing vacation. The proximity to the Gulf of Mexico provides easy access to beautiful beaches, where you can enjoy sunbathing, swimming, and various water sports.

One of the highlights of staying near the waterfront is the chance to explore nearby attractions such as the St. Marks National Wildlife Refuge. This expansive area is great for nature enthusiasts, offering opportunities for birdwatching, hiking, and taking in stunning views of the diverse ecosystems. Additionally, the nearby town of Apalachicola is known for its charming historic district and vibrant arts scene, making it a wonderful day trip destination.

In terms of vacation rentals, you will find a variety of options available along the coast, ranging from cozy cottages to spacious family homes, allowing for a comfortable and enjoyable stay.
How much does it cost to rent a vacation home in Panacea?
Prices for vacation rentals in Panacea vary based on factors like travel dates, length of stay, accommodation type, and location. Simply enter your trip details to explore a wide range of options—whether you're traveling solo, as a couple, with family, or in a group. Vrbo offers something for every taste and budget, from affordable rentals in Panacea to more spacious homes. To get the best value, book early and take advantage of Vrbo's free rewards program.
Are there any discounts for Panacea vacation house rentals?
You can find great discounts on house rentals in Panacea on Vrbo, including special rates on new listings and savings for weekly or monthly stays with top amenities such as a pool or parking. There are several discounts for Last minute bookings, and Early bird bookings too. The best part is, there's no need for a discount code—just enter your travel dates and apply the discount filters to view the top rates.
Where are the best areas for renting a beach house in Panacea?
For renting a beach house in Panacea, Florida, travelers should focus on the scenic areas along the Gulf Coast. The stretch near the Panacea waterfront offers a variety of vacation rentals with stunning views of the water and easy access to the beach. Many properties in this area come with amenities such as private decks, outdoor grills, and spacious living areas, making them ideal for families or groups wanting to enjoy coastal living.

Additionally, nearby Bald Point State Park provides beautiful natural surroundings and is great for outdoor enthusiasts. Rentals in this vicinity often feature proximity to walking trails, picnic areas, and access to pristine beaches, with several properties offering outdoor showers and ample parking for boats, which is great for those looking to explore the nearby waters.

Travelers can also explore the charming local community with its seafood restaurants and markets, adding to the beach experience. Find your rental near the beach in Panacea.
What is the most popular type of vacation rental accomodation in Panacea?
In Panacea, vacation houses are the most popular rental option, with about 150 available throughout the area. These houses typically feature spacious layouts, multiple bedrooms, and fully equipped kitchens, making them ideal for families and larger groups. Many also come with outdoor spaces like decks or patios, superb for enjoying the warm Florida weather. Additionally, there are around 24 cozy cottages, which offer a charming, rustic experience with unique decor and often proximity to the water. For those looking for a more compact stay, several condos and apartments are available, usually equipped with basic kitchen facilities and comfortable living areas.
Are there any family house rentals in Panacea?
In Panacea, Florida, there is a wealth of family-friendly house rentals available, with about 131 options to choose from. This coastal locale is superb for families looking to enjoy a laid-back atmosphere while being near the beautiful Gulf of Mexico. Many of these homes feature spacious interiors, fully equipped kitchens, and outdoor areas ideal for barbecues or relaxing in the sun.

Families can also find amenities such as game rooms, private yards, and proximity to the area's natural attractions, including the nearby Apalachicola National Estuarine Research Reserve, which offers opportunities for kayaking and wildlife observation. The charming nearby town of Sopchoppy is known for its local eateries and friendly vibe, making it easy for visitors to immerse themselves in the local culture while enjoying their stay. See all family-friendly rentals in Panacea.
Can I rent a vacation home with a pool or hot tub in Panacea?
In Panacea, Florida, there are plenty of vacation homes available for rent that feature pools and hot tubs, with around 36 options to choose from. This charming coastal town is located near the Gulf of Mexico, offering a serene environment great for relaxation. Many of these rentals can be found near the scenic coastline, providing easy access to beautiful beaches and natural surroundings.

Travelers can expect a variety of amenities in these properties, including private swimming pools, inviting hot tubs, spacious outdoor decks, and fully equipped kitchens that make dining in a pleasure. Some homes may also offer additional features such as outdoor grills and cozy fire pits, ideal for enjoying the warm Florida evenings. Find your rental in Panacea with a pool or a hot tub.
Can I find long-stay vacation rentals in Panacea?
A long-stay vacation rental in Panacea is the best way to experience local living. Plus, you can make the most of long-stay discounts. For month-long stays, save an average of 19%, and for week-long bookings you can save an average of 10%.* Long-stay discounts are applied automatically when you enter your vacation dates into the search tool, or you can use the "Weekly stay" and "Monthly stay" filters in your search.

*Based on analysis of Vrbo booking and occupancy data for 2024 stays.
Are there pet-friendly house rentals in Panacea?
In Panacea, Florida, there are numerous pet-friendly house rentals available, with around 89 options to choose from. Many of these vacation homes offer amenities that cater to both travelers and their furry companions, such as spacious yards, outdoor patios, and easy access to nearby beaches. Visitors can expect features like fully equipped kitchens, comfortable living areas, and sometimes even private pools, making them ideal for families or groups enjoying a getaway with pets.

The area is also close to natural attractions such as the nearby Bald Point State Park, where pet owners can enjoy scenic trails and beachfront access, allowing for enjoyable outings with their pets. Additionally, the charming coastal town ambiance, along with local shops and restaurants that may welcome pets, enhances the experience for travelers looking to explore the area with their animal companions. See all pet-friendly rentals in Panacea.
Are there any remote work vacation rentals in Panacea?
In Panacea, Florida, there are numerous options for remote work vacation rentals, with around 170 properties available. This charming coastal area offers a serene environment ideal for productivity while enjoying a getaway. Many rentals come equipped with essential remote work amenities, including high-speed Wi-Fi, dedicated desks, comfortable desk chairs, and even office spaces. Some properties may also feature laptop workspaces and computer monitors, suiting various work needs.

Travelers can expect comfortable living arrangements that allow for a balance of work and relaxation, often with proximity to beautiful nature and coastal views. The nearby areas offer opportunities for outdoor activities, such as kayaking and fishing, which can provide a refreshing break from work. To help narrow your search, insert your dates and apply the "WiFi" filter on Vrbo.
Are there any Panacea vacation rentals with parking?
Vrbo offers a wide selection of vacation rentals in Panacea with parking available—perfect for families or travelers who value the convenience of having a car during their stay. To easily find these properties, simply enter your travel details on Vrbo and use the "Parking available" filter under the amenities section. This makes it quick and easy to browse listings that suit your needs, whether you're planning a short city break or a longer stay.
What are popular rental amenities in Panacea?
In Panacea, popular vacation rental amenities include WiFi, which allows guests to stay connected during their stay, and fully equipped kitchens that enable travelers to prepare their own meals. Many rentals also feature blenders, making it easy to whip up smoothies or other blended drinks. Outdoor spaces are common, with patios providing a superb setting to relax and enjoy the warm Florida weather. Additionally, coffee and tea makers are typically available, ensuring that guests can start their day with a fresh brew.
When is the best time to visit Panacea for a vacation rental?
The best time to visit Panacea for a vacation rental is during the peak season from April to June. This period draws travelers seeking sun-soaked adventures and the chance to experience the natural beauty of Florida's Gulf Coast. The inviting weather, with temperatures typically ranging from the mid-70s to low 90s Fahrenheit, creates an ideal environment for outdoor activities such as kayaking, fishing, and exploring the nearby wildlife refuges.

June stands out as the most popular month, offering vibrant local events and a lively atmosphere that enhances the vacation experience. Whether you're basking on the sandy beaches or enjoying fresh seafood at local eateries, there's something for everyone in Panacea during this time.

For those looking for a more budget-friendly option, November can be a delightful time to visit. This month allows for a quieter experience, with fewer crowds and the opportunity to enjoy the area's natural beauty without the peak season hustle. Visitors can appreciate the serene coastal environment, great for leisurely strolls along the beach or exploring the nearby nature trails.

Ultimately, your ideal time to visit Panacea hinges on your personal preferences—whether you thrive in the vibrant atmosphere of peak season or prefer the tranquil charm of the off-peak months.
How early should I book a Panacea vacation rental?
Book your Panacea vacation rental at least two months before you travel for the best selection of properties.* Plus, you'll typically find that the earlier you book your vacation rental, the better the price.

*Based on analysis of Vrbo booking and occupancy data for 2024 stays.
What are the top attractions in Panacea?
In Panacea, Florida, visitors can enjoy a range of attractions that highlight the area's natural beauty and outdoor activities. The nearby Ochlockonee River State Park is a wonderful spot for hiking, fishing, and birdwatching, offering vacation rentals that provide easy access to these recreational opportunities. The park features scenic trails and picnic areas, making it ideal for families and nature enthusiasts.

Additionally, the coastal area around Panacea boasts beautiful beaches, such as those found at St. Teresa, which are superb for swimming, sunbathing, and shell collecting. Vacation homes here often provide a peaceful retreat with stunning views of the Gulf of Mexico.

For those interested in marine life, the Panacea area is close to the Gulf Specimen Marine Lab, where visitors can learn about local marine ecosystems through interactive exhibits and touch tanks. This educational experience is just a short drive from many local rentals, providing a unique family-friendly activity.
Can I change or cancel my Panacea home rental booking on Vrbo?
To find Panacea vacation rentals with free cancellation, just use Vrbo's handy "Free cancellation" search filter. We get that plans can change, so it's easy to filter properties that give you flexibility. If you need to make changes to an existing booking, drop your host a message. Go to "My Trips" in your account, click "Change or Cancel" and then "Message Host". Vrbo rentals give you the privacy of having the entire place to yourself, and for extra flexibility, some travelers can choose to pay over time with Affirm. Whether you're adjusting your plans or looking for flexible payment options, Vrbo makes it easy to book with confidence.
Why should I join Vrbo as a host?
Joining Vrbo as a host opens the door to a global community of travelers seeking unique stays, giving you the opportunity to earn income from your property on your terms. With user-friendly tools, dedicated support, and exposure on major travel sites, Vrbo makes it easy to list, manage, and succeed. Whether it's a cozy cabin or a beach condo, you can turn your space into a standout destination, become a host and let Vrbo handle the heavy lifting to help you thrive.Earn a Premier Host badge by providing quick, reliable communication and consistently delivering outstanding guest experiences.
Are all fees included in the Panacea vacation rental prices shown on Vrbo?
Vrbo provides upfront pricing from the moment you start your search. There are no hidden fees added during the check-out process. This allows you to compare properties with ease and plan your trip with confidence.
What is VrboCare™ and how does it work?
Vrbo's mission is to help guests relax, reconnect, and enjoy precious time together. With VrboCare™, you can have peace of mind knowing you're protected and that if something goes wrong, we will do our best to make it right as applicable.If a significant issue arises that your host can't resolve, we'll help you address it, find a similar property, or get your reservation refunded if applicable. That's our promise. If a home is significantly different than listed, we'll get you into a new space that meets your needs and makes it right, or if a host cancels before your stay, you have a dedicated support team to get you into a similar home as applicable.
What can I expect from Vrbo customer service and VrboCare™ support?
Your peace of mind is our priority. Whether you're planning your trip or have already finished your stay, VrboCare™ is here to support you every step of the way. For urgent situations like last-minute cancellations, booking issues, or potential fraud, Vrbo customer service is available 24/7 to help resolve problems quickly and effectively.Vrbo also offers support via live chat through our Help Center, where you can find helpful resources on bookings, payments, property management, and safety, making it easy to get instant answers to many common questions.
Can I plan a group trip on Vrbo?
Vrbo's Trip Planner makes organizing group trips easy and stress-free. Whether you're planning with friends or coordinating a large group, you can collaborate in one place, save and share properties, vote on favorites, and build the perfect itinerary together.

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